<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28132

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMEVPGPDSDWRSPQFRQKVVAQIEEAMRKAGTAHTKSSNDMENHVYVKAKSREEYLSLVARLIIHFRDILTDKKTHGGPDPINALTNLTGVGGGPGVMGMGPRPAGAPVGGMGSMGPMQMVAGNPQQGAHTSAPPDLCPSFPSPPPAVGGPGQMPMQQMVQQQSIQFQQHCSISNRREQQTEHLCKIKSRAVDEYFRFIAVEFEEVRAAASGWRLAVVVGTNHSNSLVVNITYTDICLSCSFDQMHQTRIQQQQQILQLQHVQSIQHMVQQQQQQVQPQPGQHILQKTLQQAAAQAQHNATAGAPGQPPISQTQKSQIKRGKLKTTLVRPVMQIPTRMPQNPPTPAVGGQPMTQQMICFICTRLQRNCIQSERGRTRVSPPPHTGAQRLLVHFPPLVSLFWDGRSLLDLIQSLLAQSQTQQQPMMSSPSPGQVQTPLSMPPPPQPSPQPPSSQPNSASSGPTPSPGGFQPSPSPQPSQSPATARTPLNYGVPSPGPLNTPGNPGSVMSPPGSTSLEDQQYMEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEKLKNDMAVPTPPPPQLPNKQQYLCQPLLDAVMANIRSPVFNHSLYRTFAPAMTAIHGPPITAPNFSGRKRKHEEDERQSIPNILQGEVARLDIKFLVNLDPSYCSNNGTVHLVCKLDDKNLPSVPPLQLSVPADYPDQSPYWADEEDQYGANGFLQTVHRNMTSKLLQLPDKHSVTELLNTWAQSVRQACLSAA
Length775
PositionTail
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.05
Grand average of hydropathy-0.573
Instability index68.45
Isoelectric point9.24
Molecular weight85194.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28132
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     171.12|      27|      28|     440|     466|       1
---------------------------------------------------------------------------
  117-  144 (27.47/ 6.04)	PMQMVAG.NPQQG...ahtsaPPDLCPSFPSP...
  145-  166 (28.75/ 6.72)	..PPAVG.GP..G........QMPMQQMVQQQSIQ
  419-  453 (46.42/16.13)	TQQQPMMSSPSPGqvqtplsmPPPPQPSPQPPSSQ
  454-  483 (38.16/11.73)	PNSASSGPTPSPG....gfqpSPSPQPS.QSPATA
  484-  512 (30.33/ 7.56)	RTPLNYG.VPSPG....plntPGNPGSVMSPPGS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.42|      19|      23|     270|     290|       3
---------------------------------------------------------------------------
  270-  288 (34.23/10.69)	QQQQQQVQPQPGQHILQKT
  295-  313 (30.19/10.09)	QAQHNATAGAPGQPPISQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.75|      20|      23|     549|     569|       4
---------------------------------------------------------------------------
  549-  568 (33.12/15.48)	KD.......LSKMKSLLNILTDPNTRC
  571-  597 (26.63/12.59)	KTlqkceiaLEKLKNDMAVPTPPPPQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.22|      31|      36|     325|     359|       6
---------------------------------------------------------------------------
  325-  359 (52.00/39.22)	TTLVRPVMQIPT.RMPQNPPtPAVGGQPMtqqMICF
  362-  393 (53.22/28.41)	TRLQRNCIQSERgRTRVSPP.PHTGAQRL...LVHF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.30|      10|      15|      90|      99|       7
---------------------------------------------------------------------------
   90-   99 (21.48/ 9.72)	GVG.GGPGVMG
  106-  116 (16.82/ 6.03)	GAPvGGMGSMG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28132 with Med15 domain of Kingdom Metazoa
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