<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28130

Description Mediator complex subunit 25
SequenceLMEPSTKPATSQVADVVFVIEGTANLGPYFESLRKNYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADNLVKIIRDRGIHFSVVAPRKLPALRSLFERASPVGGAVEPHLEYSQDPFHMVLVRGISLPVSSGGGPGPLKPVLPPQPLAVSQHLGGASQPPQPMNSTHPYQNTTPMTAALAAAQKAVETASNQKSRCEPMMSQQQVPPNQPVPPPVQPISNQQPQIAPQQPPTVNQPTLPPAQLNMDLLKLLTSGSGSKPEAVPLLPKIIFIKSKAGVSGPPANANPMGQQQGVANKIVAWTGVLEWQEKPKASSMDSATKLTRSLPCQVHVNQGENLNTDQWPQKLIMQLIPQQLLTTLGHLFRNSRMVQFLFTNKDVESLKGLYRIMANGFAGCVHFPHTTSPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRAEGSDVQRGGQNKLGGAGPMQPVQVAPNQNFLNRPPGPIPVSHGNVQQQMAMRAAGPANQQPPVGGAPPNQIAQSGQAQAQGPILRLSNPGANPQLRSLLLSQQQPGRGVPHDRHDVPPGFRAAVGPFGPRRGGSNAGPVEAALGRSASEPPPSQWWKASNVPTRFAGQMLMSGGQRGVVPQQGMSQVSSVMEDELLMELM
Length748
PositionUnknown
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.06
Grand average of hydropathy-0.288
Instability index48.18
Isoelectric point9.03
Molecular weight80252.92
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats
>MDP28130
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     289.59|      47|      48|     540|     586|       1
---------------------------------------------------------------------------
  220-  260 (29.68/ 6.42)	..........................RGISLPVssgGGPGPLK.PVLPPQplaVSQHLGgasQPPQPM
  264-  315 (63.04/23.56)	H.P....YQNTtpmtaalAAAQKAVETASNQKS...RCEPMMS.QQQVPP...NQP.VP...PPVQPI
  540-  586 (87.11/35.93)	HKQ....VQQH.......RAEGSDVQRGGQNKL...GGAGPMQ.PVQVAP...NQNFLN...RPPGPI
  590-  631 (63.65/23.87)	HGN....VQQQ....mamRAAGPANQ...QPPV...GGAPPNQ.IAQSGQ...AQ........AQGPI
  650-  693 (46.11/14.86)	QQQpgrgVPHD.......R...HDVPPGFRAAV...GPFGPRRgGSNAGP...VEAALG...R.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.21|      25|      77|     423|     451|       2
---------------------------------------------------------------------------
  423-  451 (36.83/35.43)	PCQVHVNQgeNLNTDQwpQKLIMQLIPQQ
  501-  525 (45.38/27.01)	PCEVRVLM..LLYSSK..KRIFMGLIPND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.64|      64|     327|       3|      72|       3
---------------------------------------------------------------------------
    3-   72 (99.71/64.87)	EPSTKPATSQVaDVVFVIegTANLGPYFESLrknYILPAIEYFN.....GGPPAETDFGGDYGGTQYGLVVFNTV
  332-  400 (106.93/54.54)	QPTLPPAQLNM.DLLKLL..TSGSGSKPEAV...PLLPKIIFIKskagvSGPPANANPMGQQQGVANKIVAWTGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.60|      18|     288|     167|     206|       4
---------------------------------------------------------------------------
  148-  165 (33.51/35.15)	PYLLPAVESV....SYTGCTAD
  183-  204 (26.09/17.67)	PRKLPALRSLferaSPVGGAVE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.47|      16|      24|     456|     471|       5
---------------------------------------------------------------------------
  456-  471 (30.21/19.15)	LGHLFR...N..SRMVQFLFT
  478-  498 (22.25/12.30)	LKGLYRimaNgfAGCVHFPHT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28130 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGGPGPLKPVLPPQPLAVSQHLGGASQPPQPMNSTHPYQNTTPMTAALAAAQKAVETASNQKSRCEPMMSQQQVPPNQPVPPPVQPISNQQPQIAPQQPPTVNQPTLPPAQLNMDLLKLLTSGSG
2) HKQVQQHRAEGSDVQRGGQNKLGGAGPMQPVQVAPNQNFLNRPPGPIPVSHGNVQQQMAMRAAGPANQQPPVGGAPPNQIAQSGQAQAQGPILRLSNPGANPQLRSLLLSQQQPGRGVPHDRHDVPPGFRAAVGPFGPRRGGSNAGPVEAALGRSASEPPPSQWWKASNVPTRFAGQMLMSGGQRGVVPQQGMSQVSSVME
229
540
353
740










Molecular Recognition Features






MoRF SequenceStartStop




NANANA