<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28129

Description Mediator complex subunit 25
SequenceMEPSTKPATSQVADVVFVIEGTANLGPYFESLRKNYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTADNLVKIIRDRGIHFSVVAPRKLPALRSLFERASPVGGAVEPHLEYSQDPFHMVLVRGISLPVSSGGGPGPLKPVLPPQPLAVSQHLGGASQPPQPMNSTHPYQNTTPMTAALAAAQKAVETASNQKSRFPGMINQGPPFDHLPTIPSVAGVKLNQISIATVTTSSQPMMSQQQVPPNQPVPPPVQPISNQQPQIAPQQPPTVNQPTLPPAQLNMAGVSGPPANANPMGQQQGVANKIVAWTGVLEWQEKPKASSMDSATKLTRSLPCQVHVNQGENLNTDQWPQKLIMQLIPQQLLTTLGHLFRNSRMVQFLFTNKDVESLKGLYRIMANGFAGCVHFPHTTSPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRAQLGGAGPMQPVQVAPNQNFLNRPPGPIPVSHGNVQQQMAMRAAGPANQQPPVGGAPPNQIAQSGQAQAQGPILRLSNPGANPQLRSLLLSQQQPQGGVSHMTGMMSHQGLGQQLVHSAPGGGAQMQGQWRQPLGGQMLMSGGQRGVVPQQGMSQVSSVMEDELLMELM
Length722
PositionUnknown
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.06
Grand average of hydropathy-0.248
Instability index48.51
Isoelectric point8.63
Molecular weight77407.74
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28129
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     168.61|      22|      23|     661|     682|       1
---------------------------------------------------------------------------
  330-  342 (27.00/ 7.40)	PMMSQ.QQ.V.........PPNQ.P
  560-  581 (28.84/ 8.44)	GPMQP.VQ.VAPnQNFLNRPPGP.I
  598-  614 (30.60/ 9.44)	GPANQ.QPPVGG......APPNQ.I
  615-  636 (30.87/ 9.59)	AQSGQ.AQAQGP.ILRLSNPGAN.P
  661-  677 (25.03/ 6.29)	......HQGLGQ.QLVHSAPGGG.A
  678-  701 (26.28/ 7.00)	QMQGQwRQPLGG.QMLMSGGQRGvV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.35|      36|      36|     244|     279|       2
---------------------------------------------------------------------------
  201-  242 (46.90/15.03)	AVEPHLE.YSQDPFhmvlvrgislPVSSG...GG..PGPLKPVLPPQP
  244-  279 (64.01/22.99)	AVSQHLGGASQPPQ..........PMNSTHPYQN..TTPMTAALAAAQ
  281-  318 (51.43/17.13)	AVETASNQKSRFPG..........MINQGPPFDHlpTIPSVAGVKLNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.33|      33|     322|      39|      71|       4
---------------------------------------------------------------------------
   39-   71 (61.53/32.11)	PAIEYFNG..GPPAETDFGGDYGGTQYGLVVFNTV
  372-  406 (55.80/28.41)	PAQLNMAGvsGPPANANPMGQQQGVANKIVAWTGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.98|      21|      24|     462|     482|       7
---------------------------------------------------------------------------
  462-  482 (38.05/24.42)	LGHLFR...N..SRMVQFLFTNKDVE
  484-  509 (31.93/19.40)	LKGLYRimaNgfAGCVHFPHTTSPCE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.86|      11|      73|     447|     457|       8
---------------------------------------------------------------------------
  447-  457 (18.25/ 9.64)	QKLIMQLIPQQ
  521-  531 (19.61/10.86)	KRIFMGLIPND
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28129 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGPGPLKPVLPPQPLAVSQHLGGASQPPQPMNSTHPYQNTTPMTAALAAAQKAVETASNQKSRFPGMINQGPPFDHLPTIPS
2) ISIATVTTSSQPMMSQQQVPPNQPVPPPVQPISNQQPQIAPQQPPTVNQPTLPPAQLNMAGVSGPPANANPMGQQQ
3) KQVQQHRAQLGGAGPMQPVQVAPNQNFLNRPPGPIPVSHGNVQQQMAMRAAGPANQQPPVGGAPPNQIAQSGQAQAQGPILRLSNPGANPQLRSLLLSQQQPQGGVSHMTGMMSHQGLGQQLVHSAPGGGAQMQGQWRQPLGGQMLMSGGQRGVVPQQGMSQV
229
319
547
310
394
709










Molecular Recognition Features






MoRF SequenceStartStop




NANANA