<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28124
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGGPAVRVSIESTCEKQVQEVALDGTETYVPPLSMSQNLAKLAQRIDFSQGSDSEEDGIDGKPRDREWTKQEPEEEEGTVKFQPSLWPWDSVRNNLRSALTEMCVLHDVLSVVKEKKYMALDPVSQDPTAGKTPQVFQLISKKKSLGTAAQLLLKGAEKLSKSVAENMENRRQRDFNSELLRLRSQWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKLPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVTLFRRPPKTKAGTQQWHVKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPGLQLSISLCHSTGEKKNHRATPDKPKPDDHLYVLEHNLHQMMREFHKQQLSSVVMPHPASAPFGHKRMRLAGPMAYDKAEITSLQHNEGLLEKIIKQAKHIFLRSRTARTIDSLASRIEDPQIQAHWSNINDVFESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVVTLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGPVESIGNASAVTVASPNGEYAISVRNGPESGCKVLVQFPRSQTKELPKSDVIQDAKWSHLRGPSKEVHWSKMEGRNFVYKMELLMAALTPCP |
Length | 643 |
Position | Head |
Organism | Gasterosteus aculeatus (Three-spined stickleback) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata>
Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae>
Gasterosteus.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.476 |
Instability index | 49.60 |
Isoelectric point | 8.55 |
Molecular weight | 72193.70 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP28124
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 347.04| 100| 252| 284| 388| 1
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284- 388 (156.26/116.74) WHVkLEAAQNVLLcKEIFAQLSREAVQIKSqiPHIVVKNQIISQPFPGLQLSISLCHS.TGEKK...NHRATPDKPKpDDHLYVLEHNLH..QMM.REF.HK...........QQ.LSSVVMPHP
468- 537 (49.04/24.43) ....................................VKVLITSQGYEQICKSIQLQLN.IGVEQirvVHR........DGRVVTLSHQ.E..QEL.QDF.LLsqmsqhqvhavQQ.LAKVM....
539- 643 (141.74/87.66) WHV.LSFSNHVGL.GPVESIGNASAVTVAS..PNGEYAISVRNGPESGCKVLVQFPRSqTKELP...KSDVIQDAKW..SHLRGPSKEVHwsKMEgRNFvYK...........MElLMAALTPCP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 121.09| 42| 66| 161| 204| 2
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161- 204 (65.64/64.23) LSKSVAEN...MENRRQRDFN.SELLRLRSQWKLRKVGDkiLGDLS.YR
226- 272 (55.45/46.10) LDKKLPEDycpLDVQIPSDLEgSAYIKVSIQKQAPDIGD..LGTVTlFR
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