<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28105

Description Cyclin-dependent kinase 19
SequenceMDYDFKTKLAAEREKVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREVALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKGNKKPTQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDKDWEDIRKMPEYPTLQKDFRRTTYATSSLIKYMEKHKVKPESKVFLLLQKLLTMDPTKRITSEHSLQDPYFLEEPLPTTDVFAGCQIPYPKREFLNEDEPEEKTEKNLAQTNGNAGATGAATGGGLQHGQDQGPHNKKPRIGPSGASSGTGLLQSEYQLSGSRLGYQSSIQGSTQPQGTMGYSSSSQQSSHYSHQTHRY
Length415
PositionKinase
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.09
Grand average of hydropathy-0.693
Instability index46.47
Isoelectric point9.10
Molecular weight47123.03
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28105
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.87|      19|      35|     313|     346|       1
---------------------------------------------------------------------------
  316-  342 (22.92/33.53)	PEEKteKNLAqtngnaGATGAATGGGL
  350-  368 (36.96/10.73)	PHNK..KPRI......GPSGASSGTGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      35|     151|     165|       2
---------------------------------------------------------------------------
  151-  165 (26.77/18.28)	DLKPANILVMGEGPE
  189-  203 (28.67/20.05)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.97|      27|      40|     229|     261|       4
---------------------------------------------------------------------------
  229-  261 (37.01/31.66)	PTlqkdfRRTTYATSSLIKYMEKHKVkPESKVF
  272-  298 (48.96/25.68)	PT.....KRITSEHSLQDPYFLEEPL.PTTDVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.31|      12|      14|     377|     389|       5
---------------------------------------------------------------------------
  377-  389 (18.69/15.97)	GSrLGYQSSIQGS
  394-  405 (23.63/14.77)	GT.MGYSSSSQQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28105 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKTEKNLAQTNGNAGATGAATGGGLQHGQDQGPHNKKPRIGPSGASSGTGLLQSEYQLSGSRLGYQSSIQGSTQPQGTMGYSSSSQQSSHYSHQTHRY
305
415










Molecular Recognition Features






MoRF SequenceStartStop




1) DQGPHNKKPRIGPS
2) HYSHQTHRY
3) TGLLQSEYQLSGSRLGYQSSIQGSTQPQGTMGYSSS
347
407
366
360
415
401