<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28104

Description Cyclin-dependent kinase 19
SequenceMDYDFKTKLAAEREKVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDEKEYALKQIEGTGISMSACREVALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKGNKKPTQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYATSSLIKYMEKHKVKPESKVFLLLQKLLTMDPTKRITSEHSLQDPYFLEEPLPTTDVFAGCQIPYPKREFLNEDEPEEKTEKNQTQPHQQTTGQTQAQNQQQTAPQQAPSLQNLAQTNGNAGATGAATGGGLQHGQDQGPHNKKPRIGPSGASSGTGLLQSEYQLSGSRLGYQSSIQGSTQPQGTMGYSSSSQQSSHYSHQTHRY
Length449
PositionKinase
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.08
Grand average of hydropathy-0.784
Instability index47.69
Isoelectric point8.54
Molecular weight50993.92
Publications









Function






Annotated function


ECO:0000256	RuleBase:RU364143

GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats
>MDP28104
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.43|      17|      20|     276|     294|       1
---------------------------------------------------------------------------
  276-  294 (26.96/23.20)	PTKRITSehSLQDPY....FLEE
  297-  317 (28.47/16.99)	PTTDVFA..GCQIPYpkreFLNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.66|      17|      20|     329|     347|       2
---------------------------------------------------------------------------
  331-  347 (31.93/21.01)	PHQQTTGQTQAQ...NQQQT
  349-  368 (24.74/ 8.91)	PQQAPSLQNLAQtngNAGAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.88|      13|      15|     408|     421|       3
---------------------------------------------------------------------------
  408-  421 (19.44/16.17)	QLSGSrLGYQSSIQ
  425-  437 (26.45/16.56)	QPQGT.MGYSSSSQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28104 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPEEKTEKNQTQPHQQTTGQTQAQNQQQTAPQQAPSLQNLAQTNGNAGATGAATGGGLQHGQDQGPHNKKPRIGPSGASSGTGLLQSEYQLSGSRLGYQSSIQGSTQPQGTMGYSSSSQQSSHYSHQTHRY
307
449










Molecular Recognition Features






MoRF SequenceStartStop




1) GLQHGQDQGPHNKKPRIGPS
2) HYSHQTHRY
3) TGLLQSEYQLSGSRLGYQSSIQGSTQPQGTMGYS
375
441
400
394
449
433