<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28102

Description Mediator of RNA polymerase II transcription subunit 1
SequenceVECQMQLLKSEKQSRMAALLEKLHAKHNASRPWQETCKVVRQAMEKRSVMNAAGHQLVLTCLETLQRALKVSSLPSMTDRLESIARQNLLGSHLSPSGTECYITSDMFYVEVQLDTNGQLVDVKVAHQGENPTSCPELIQHLREKNFEEFSKHLKGLVELYKLPGDNKLKTKMYIALQSLELDLTKMMHMFRLATNANAVETILHGSVGLLTARSGGHLVSLQCYVSPYDLFDEGLTTQLNLPDGNVPRSLGVSVFVTIEGTSAVYKLPIAPLITGSHPVDNKGSPSFSTVTNSNCVDLPACFFLKLNRPMPFSRSFIQRLGNATSIPVFESSPSLSPLYQLIVHSQHQLSEEGSKTPLPSHNMHFYSVLPDQQHCYFLNGDAPVQDGRCLQGALVSKIPFRHPAQVPLLLDIIRHQAAYNNLVSSCVKRTSIKEDSAGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMEVIDSRQVSCKLYKGLSDALICTDEFITKVVQRCMSIPVSMRAIRRKAETIQADTPALSLIAQTVEIMVKNNLPPSSSPTYNMAAGDGTNPMGLPGLAGGNTPTGPGLPGGPNFGAPINTLFGVSRTERLQQPGQGHADDFNKVTQNPILTSLLQITGNVGSSPSSQNAPQPHQTPPPTSSPASNTKNHPMLMNLLKDNPTQDFATLYASSPLERPNSSSGSPRTESMGGSCPGSGTKGMKGSSMPPHHPHHPGEDDFHRELLSMDVDASQNSIFDVNLTGDGLDTPHSITPAPSQCGTPPSGPNMPYSQSHVHAQQQQPPGAVPPRMVRLSSSDSIGPDITEILSDLPEQTGKLGNGGEDGGPLGTPIRDSSSSGQGSAVFDSADIFNTNSNENPFTDPADLIAEAAATAATPTSDSSSTNFFPDAADFNSDLLNSAHGFSQNYFDDSSPSADGDMDLVKGFGGSSQQNTPSGTPQNPTPHGQNTPEPSIKDPFDMGIVFGGNSGGGKPLLGQAPDLGDAHGGGSQSPLIMGLATGCAEPKMKQVLMRPKDENGASGGSSSVLGTSSTEAKQFKRSRTPSSEGKSKEKPAKRKKLDTDGKSPSHSSGGRPYTPPSGGSGSGGSISGGGSKSPGSSGRSQTPPGGATPPIPKITIQIGKGTIMGGKTSSHSGYTSSSSATSSTGGAGGTGGSKSHHSHSSSSGKIKSKEGSVTQGTSSKPGSAGMGSGGGSSQSKGSSQGLGVGKPGSSPITKHGLTGPGGSGTGSGSKMKPQGGKPPGSLMNPNMKPNISPSHSRSSNSGDKLSSPMKTQQSQVPGTPPSSRAKSPMGSGGGSSGGSKSSGGGMSSQKPMGGNSSGSTSSSSSSSSSGSMAFSGGSQGSGGGAGQNNANNPNAKGKSPSRNKKPSLTAVIDKLKSVGGGGVGEDGCEGNVPSSGPSNLGPSKHSSSSQSGEYKRERSDKEAKAKVSVSGGNSGDKKLMEPKTGGGSATGLAKIIISKPDGGSPTIRGKGSLQKTGEGSGDSMRPQISSLKASPLFSGSTPKHDRSSPSHSRSPGYTPLNHDSESESGSSSVAEKSHQNSPSSDDDQSVRPLPHQDYMSSIPLGSSSMSMGPSSHPIKADSWSRSPIAASDSSLSMLGAERPSRPSPMYMRNEDDDLMDSALTGN
Length1635
PositionMiddle
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.04
Grand average of hydropathy-0.577
Instability index55.82
Isoelectric point8.43
Molecular weight169498.47
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28102
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            13|    1136.10|     107|     114|    1027|    1133|       1
---------------------------------------------------------------------------
  548-  661 (80.61/14.34)	...........SPTYN.MAAGDG...TN..PMGLP..GL......A.GG..NTPTG...PGLPGgpnfgapintlfgvsrteRLQQP.....GQGHADD....FNK....VTqnpiltslLQI.TGNV............gSS.....PSSQNAPQPHQTPPPTSspASNTK......NHPM
  662-  744 (72.76/12.23)	LMNLLkDNPTQDFATL.YASSPL...ER..PNSSS..GSprtesmG.GS..CPGSGTK..GMKG..................SSMPPhhphhPG...........................................................EDDFHR.ELLSM..DVDAS......QNSI
  745-  823 (84.19/15.30)	FDVNL.TGDGLDTPHS.ITPAPSqcgTP..PSGPNmpYS......Q.SH..V..........HA..................QQQQP.....P.GAVP......PR....M.........VRL..................SSSDSIGPDITEI....LSDLPEQ..TG.............
  824-  895 (72.24/12.09)	...KL.GNGGE......DGGPLG...TPirDSSSS..GQ......G.SA..VFDSADIFNTNS....................NENP........FTDP....ADL....IA...................................EAAATAA.......TPTS..DSSST......NFFP
  896-  960 (77.48/13.50)	DAADF.NSDLLNSAHG.F.SQNY...FD..DSSPS..AD......G.DMdlVKGFG....GSS...................QQNTP.....SGTPQNP....TPH.................GQ...................................NTP................EPS
  961- 1061 (128.80/27.31)	IKDPF.DMGIVFGGNS.GGGKPL...L.....GQA..PD......L.GD..AHGGGSQSPLIMG.....................LA.....TGCAEPK....MKQ....VL........MRPKDENGA.........SG.GSSSVLGTSSTEAKQFKRSRTPSS..EGKSK......EKPA
 1062- 1157 (161.00/35.98)	KRKKL.DTDGKSPSHS.SGGRPY...TP..PSGGS..GS......G.GS..ISGGGSKSPGSSG..................RSQTP.....PGGATPP....IPK....IT........IQIGKGTIM.........GG.KTSSHSGYTSSS......SATSST..GGAG...........
 1158- 1216 (65.56/10.29)	.......GTGGSKSHH.S....H...SS..SSGKI..KS......KeGS..VTQGTSSKPGSAG..................................M........................GSG.....................GGSS....QSK....GSS..QGLGV......GKP.
 1217- 1286 (77.63/13.54)	.........GSSPITK.HG...L...TG..P..............G.GS..GTGSGSKMKPQGG..................K...P.....PGSLMNP..nmKPN....IS................P.........SH.SRSSNSGDKLSSPMKTQQSQVP...................
 1287- 1327 (53.08/ 6.93)	.........GTPPS.....SRAK...SP......M..GS......G.GG...SSGGSKSSGGGM..................SSQKP.....MG..........................................................................GNSS......G...
 1328- 1423 (81.80/14.66)	......STSSSSSSSS.SGSMAF........SGGS.qGS......G.GG..AGQNNANNPNAKG..................KS..P.....SRNKKPSltavIDK....LK.........SVGGGGVGedgcegnvpSS.GPSN.LG..........PSKHSSS.....SQ......SGEY
 1424- 1511 (81.60/14.61)	KRERS.DKEAKAKVSV.SGGN..........SGDK..KL......M.EP..KTGGGSAT.GLAK..................IIISK.....PDGGSP.............T........IR.GKGSLQ.....ktgeGS.GDSMRPQISSLKASPLFSGSTP...................
 1512- 1613 (99.37/19.39)	..KH....DRSSPSHSrSPG..Y...TP..LNHDS..ES......E.SG..SSSVAEKSHQNSP..................SSDDD.....Q..SVRP....LPHqdymSS........IPLGSSS.M................SMGPSSHPIKADSWSRSPIA..ASDSSlsmlgaERPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.81|      66|      71|     277|     345|       2
---------------------------------------------------------------------------
  277-  345 (106.92/70.42)	SHPVDNKGSPSFSTVTNSNCVDLPACFFLKLNRPMPFSRSFIQRLgnATSIPvFESSPSLSPLYQLIVH
  351-  416 (116.89/67.13)	SEEGSKTPLPSHNMHFYSVLPDQQHCYFLNGDAPVQDGRCLQGAL..VSKIP.FRHPAQVPLLLDIIRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.04|      21|      22|     446|     467|       6
---------------------------------------------------------------------------
  447-  467 (36.97/24.48)	PLTDS.SFSVSFQHPVNESLVC
  471-  492 (31.07/13.71)	EVIDSrQVSCKLYKGLSDALIC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28102 with Med1 domain of Kingdom Metazoa
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