<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28099
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MQQREEKQLEAAVESLISRVAHVKNALHSFIYKLENEYERLTWPSVLDNFALLSGQLNTINKLLKNEKTPSFRNQVIIPLLLSPDRDEDLAKLTELRVPVFSHEIVPDYLRTKPDPEVEEQEKQLSVEAARIGPEVAQKQIQTLNKLCSNLLEKLNNPRDDRDAESSAIRQNKPSFNPADTNALVGAVAFGKGLSKCRPPGPVAPGHPGQGPMMSGGPTLQQVTIGGGSNQQAVMGGPGAPQQPGQPGKMPSSIKTNIKSASGSMHPYNR |
Length | 270 |
Position | Head |
Organism | Gasterosteus aculeatus (Three-spined stickleback) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata>
Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae>
Gasterosteus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.589 |
Instability index | 42.10 |
Isoelectric point | 8.45 |
Molecular weight | 29493.16 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP28099
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 112.95| 30| 36| 188| 223| 1
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190- 219 (63.15/31.44) FGKGLS.KCRPPGPVAPGHPGQ.GPMMSGGPT
225- 256 (49.80/14.45) IGGGSNqQAVMGGPGAPQQPGQpGKMPSSIKT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 77.65| 26| 28| 66| 92| 2
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66- 92 (40.81/28.68) NEKTPSFRNQvIIP..LLLSPDRD.EDLAK
95- 123 (36.84/21.29) ELRVPVFSHE.IVPdyLRTKPDPEvEEQEK
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