<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28093

Description Mediator complex subunit 14
SequenceMAPVQIGSDGQLVPLGGPVVSGPQPPPPGAPATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLGLVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKVEKQTTLGQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRTLVHSLQVNFIHELVQARLCADDKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEERYVPAKYLTLTVWNQQVLGRKTGTASVHKVTVKIDELDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSNQKLQELKAILKTNNPSDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQPMLYGLDQSMLDDIEKTVNDDMKRILSWLQQLKFWLGEQRSRQSVKHLPTVCSDVLHLSNSASHPVGTLSKHKLFIKLTRLPQYYIVVEMLEVPSSPTALQYKYSFLSVSQLEGDDGPMCAQLLQHFKPNLERLVQDTSGRGARPGAKRKGSGDHGEPEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRTELSNMEIANQGVQVEGDGSSHAIRLLNIPPCKGVGEETRRALERSLLDCTFRLQGRNNRTWVAELMLANCPLNSTHSKEQASPPDVDLNHQKPLSEPVGRRKGVQKFLKAWLGQVLKFAMAGTQMPSYLSLFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSNTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKSPNVMQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRSMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGVDMMDSLVSQLQPPQAMRGGAGGVYQPLTSPPPNYHPNVTPSPSMMPTQSPAGNIHASGSPSGVLRAPSPFGPTPSPSSLGIAMGQTSFASPHGALDPSSPYAMVSPSHRGPWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPHSPRAGNSSQVMPTSMPPPRKLPQRPWAASIPTILTHNALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEANLAIVNSNEPGVIMFKTDVLKCRVALNPKNYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRIPVPQEPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPARQGECTIFASVHELMANLSLPPGTRQ
Length1426
PositionTail
OrganismGasterosteus aculeatus (Three-spined stickleback)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Perciformes> Cottioidei> Gasterosteales> Gasterosteidae> Gasterosteus.
Aromaticity0.06
Grand average of hydropathy-0.197
Instability index51.37
Isoelectric point8.95
Molecular weight157475.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
blood vessel morphogenesis	GO:0048514	IEA:Ensembl
embryonic viscerocranium morphogenesis	GO:0048703	IEA:Ensembl
neural crest cell differentiation	GO:0014033	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl
ventricular system development	GO:0021591	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28093
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.96|      28|      46|     820|     848|       1
---------------------------------------------------------------------------
  820-  848 (48.37/31.86)	PNSGCSNCHNIIlHQLQEMFNKSPNVMQL
  869-  896 (50.60/29.19)	PMLGLTQRTNTA.YQCFSILPQSPTHIRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.43|      18|      19|    1029|    1047|       2
---------------------------------------------------------------------------
 1029- 1047 (31.65/14.80)	SPSGVLRAPSPFGPTpSPS
 1060- 1077 (30.78/ 9.96)	SPHGALDPSSPYAMV.SPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     239.10|      59|     149|     963|    1022|       3
---------------------------------------------------------------------------
  963- 1022 (109.60/47.65)	NPPSPVGVDMMDSLVSQLQPPQAM..RGGAGGVYQPLTSPPPNYH...PNVTP.SPSMmPTQSP..AG
 1079- 1112 (37.09/10.35)	..........................RGPWPGSPQ.VSGPSPG..ariPGMSPgNPSL...HSP..IP
 1113- 1172 (92.42/36.42)	DPHSPRAGNSSQVMPTSMPPPRKLpqRPWAASIPTILTHNA..LH...VLLLP.SPT..PCLVPglAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     285.91|      63|     130|     605|     669|       4
---------------------------------------------------------------------------
  568-  604 (42.64/18.97)	..............GPMCA..QL.LQHF......KPNLE.RL...VQDTSGRGARPGAKRKG..SG......
  606-  669 (105.14/59.79)	HGEP..EPkKPKRSGEMCAFNKE.LAHLV..AMCDTNMP.FIGLRTELSNMEIANQGVQVEG..DGSSHAIR
  674-  722 (63.57/32.14)	..........PPCKGVGEETRRA.LERSL..LDCTFRLQ.GRNNRTWVAELMLANCPL.......NSTHS..
  735-  803 (74.56/40.77)	HQKPlsEP.VGRRKG.VQKFLKAwLGQVLkfAMAGTQMPsYLSLFSEVRLYNY.RKLVLCYGttKGSSVTIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     236.59|      76|     183|     292|     387|       5
---------------------------------------------------------------------------
  295-  387 (115.17/106.57)	LHSQTL..MLIRERWGDLVQEERYVPAKYLTLTVWNQQV...LGRKTGTASVHKVTVKIDELdgskpLQISHEPPLPacdsklmeramkIDHLSVEKL
  445-  525 (121.42/71.56)	LHSGMFqpMLYGLDQSMLDDIEKTVNDDMKRILSWLQQLkfwLGEQRSRQSVKHLPTVCSDV.....LHLSNSASHP............VGTLSKHKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.22|      56|    1292|      23|      81|       7
---------------------------------------------------------------------------
   23-   81 (88.89/56.07)	PQPPPPGAPATQGVRLSLLIEFLLQRTyHEITLLAE....LLPRKTDMERKieIVQFASRTRQ
 1317- 1376 (94.32/50.20)	PSAPPIAPPGTIAVVLKSKMLFFLQLT.QRIPVPQEpvsiIVPIVYDMATG..LTQQADIPRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.84|      37|    1097|     166|     202|      12
---------------------------------------------------------------------------
  166-  202 (65.60/45.32)	PPDPITKVEKQTT.LGQLNQILRH..RLVTTDL.PPQLANL
 1265- 1305 (52.24/34.39)	PPFKYNTLNAFTKlLGAPTNILRDcvRIMKLELfPDQAAQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28093 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LVQDTSGRGARPGAKRKGSGDHGEPEPKKPKRSGE
2) NQDARRRSVNEDDNPPSPVGVDMMDSLVSQLQPPQAMRGGAGGVYQPLTSPPPNYHPNVTPSPSMMPTQSPAGNIHASGSPSGVLRAPSPFGPTPSPSSLGIAMGQTSFASPHGALDPSSPYAMVSPSHRGPWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPHSPRAGNSSQVMPTSMPPPRKLPQRPWA
585
950
619
1142










Molecular Recognition Features






MoRF SequenceStartStop




NANANA