<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28084

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGEASGRTDHDRPSTNAVVNQTGAPPDDKAMAKAAAGSDDSDPPRMNDLPNEIVHITQGFIPLSALLTRLTQVTHNSLQDKVAELVKIPIPASALNGGATNLTSSAPDDTSAENLRKKAALLHFTQDLHAKWVKALVITEWSRRAPLVSKLIDLKFHTDQLRVHYDVCLESMVNVKRDLSYARMPAPDLKTALQVLSTGSAPWISDHNYIEPPPLTAVEKLRWMKDINTRLSLRLNLEDYDKIPPQFRNYEIQSGRVTFKVPDEFEVALTIADEDNDKQFWFIDFQYAFTPSALSLSEGLRNYMENYVNDAIARGGLTGCYQFLHEMVLTAKITELKRQALRLSKTSWDGTLVVEPLHRALAIQYWSSRVSNTKSWVLIAINSGKKNGKVDTRSSSRLVATWYRDNTEVKDVQLGLDGGNLSMESLLKEVIGRHIGYILQSIRDKLLEAPRFKQHEAAMRLRISNTNPSDCRLTTQVSHSDTATLLVEPTTGIFAMKPQSKFSIQYEHQLNNGKNTAEDGVACLENVRCAMMEDELHRRGNVTGWQTQKSPLSLEETKSVTKVRDWTRSIWMRRQGWGESWYVAIFLGLGGDEWWLLDVNRNEPGRTIKFQARLPLSKGDPELSNAFWVNLTVFATGLIAQAVDMRELHRLHIKSRTSDSVNPTLPQQIHLPSIQVALSAMFPSIVHDGGPKSEYRQPWANDVVTIRFKGIETADDTLTCVSEAVLRVCKPSKFAALKGTVDGNLLYNAKLGEFCLRVQHAVGEPVLALLKSRIKAIDRFVNFLEAMDKSKGSIVGELVTLKEIRFLYCQAGSGNGSDSDSRKQWRITLDLSRDDIAIKIDRGNPHLRVVDLMQQLVNSDGGIGALMGWLPASLQALEAISSIETRWEEPQSKRLGRVEFAMKSLSWLSLQYTMTIPGPSATERPVLFQVRTKTRRGEAWWHVWRSHDGGGHHDDAYDMALKTVWNGRGPGWMGLSTGAAARSEGGIVAMLLAVDDVLRSVGVDDPSMTPGAQSSTIRSFTQPTTQSQHSAKDVVVLD
Length1040
PositionTail
OrganismCordyceps militaris (strain CM01) (Caterpillar fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Cordyceps.
Aromaticity0.07
Grand average of hydropathy-0.341
Instability index35.64
Isoelectric point7.67
Molecular weight116041.69
Publications
PubMed=22112802

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28084
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     236.85|      79|     198|     438|     546|       1
---------------------------------------------------------------------------
  316-  367 (79.70/41.95)	RGGLTGCYQF.LHEMVLTAKITELKRQALRLSKT...SWDGTLVVEPLHRALA........IQY......................
  445-  530 (120.31/143.85)	RDKLLEAPRFkQHEAAMRLRISNTNPSDCRLTTQvshSDTATLLVEPTTGIFAMKPQSKFSIQYEHQLnNGKNTAEDGVacLENVR
  902-  933 (36.84/ 8.69)	...................................................FAMKSLSWLSLQYTMTI.PGPSATERPV..LFQVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.44|      13|      29|       6|      18|       2
---------------------------------------------------------------------------
    6-   18 (25.04/13.35)	ASGRTDHDRPSTN
   37-   49 (25.40/13.64)	AAGSDDSDPPRMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.29|      24|     223|      62|      86|       5
---------------------------------------------------------------------------
   63-   86 (40.21/26.67)	IPLSALLTRLTQVTHNSLQDKVAE
   92-  115 (41.08/21.99)	IPASALNGGATNLTSSAPDDTSAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.97|      20|     662|     214|     233|      11
---------------------------------------------------------------------------
  214-  233 (37.44/23.11)	PPPLTAVEKL.....RWMKDINTRL
  873-  897 (29.53/16.71)	PASLQALEAIssietRWEEPQSKRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.08|      36|     544|     275|     311|      12
---------------------------------------------------------------------------
  275-  311 (62.28/53.19)	DEDNDKQfWFIDFQYAFTPSALSLSEG...LR..NYMENYVN
  820-  860 (52.80/38.70)	DSDSRKQ.WRITLDLSRDDIAIKIDRGnphLRvvDLMQQLVN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28084 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MENGEASGRTDHDRPSTNAVVNQTGAPPDDKAMAKAAAGSDDSDPPRMNDLPNE
1
54










Molecular Recognition Features






MoRF SequenceStartStop




NANANA