<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28080

Description RNA polymerase II mediator complex component Srb8
SequenceMAESDSDWHTLICCRNSMGVPPRAQPRAPSGSALQAHQRGLSSSYMPPLSPVRKDDHHSQPTDPTDASTTSSQASTASRHGATPRRTAGSKLRIELSNDEGLTPGPATDSPLGTPSLLSHSAALDSSTDASGHGSPALSRASHADSAIPPMPMPRRRAPLQRFVPSNKTAAPPTALLKRDSKPKQYTIEVPPPAPRYLSTNKPDTLHRDPFNKGLFSGNADFFPWNGRHHEDEWSTEAIQKGTWDRGSQNETSSARLAVYPSLKQKTGLNALSTIFMGVLNQRRNRGQITAPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAIWLAKCVGANEIRSFKRKGVTSGLAMGNELKWIRDWTIFVEQFVDSIVSSVGEPDWKRRVTYSIRLATVLYSEHLLDRDHYLDWIVSGLEGSNQAKLPMWILIAQICWTDILRSRKPGRRLVFALLNHLNTIYNDPDRDILMPLSNQLVSLLKTLVAKNPESFIQPLQWFKYRECLSAFLPTDARALQQAYRSINQRNSELLVSSAASPPIGGKEHLVKLLDATLYGKVDRELSYKCWSTSEDKTQVLKTVIEWVTSFHRPGLEKIYTATNLLRSWSGFRVNTTGAILDTLDSIEPGDVVRKQSVYRLVTELARTGHFSVSQLLVELPIYCIPEDRKTDRANLLRRAAHYNVADEARDISMAIQCVNQTVGLRATTNDGGTLPIKPIPLRKLVRRINISSFALKSAVGTHLRNAFQSLLPPRLDTDVSLHVFTSTRAILEATGDFSMLGEVLRSCSRMSNMEVLAACVDTVNVNLQVLLAVGVADDLFALYVERLKAASCEHGLVARPLLAALSSLAQRMPNQGDVAKNLQQELTQTDRSNPIDACSPVSDNMVSQATNPEGEFSEQIDKLLATGNSIDHPTMNRLFRNIVPRLETGWHKLDASRRVYASLLARLRIFDAQHFDKLISDWVSHIRSLKERPALRELLPLLVSLGCLTMVTILHTANAAPVAASVHAALDAGPPRGAAIYLEELLQLILRPLPKNTPLTADESYRFVVYQQSAQMEHAKALLLLIRNAVQEYSILRSRSTTTTLPLDDRTCQDDVLEALRVLVVTNSTAAADALSMKDLAPEAAALIRTVAAKLLTPGDTHTSSSFDKILGLANELTMPFCQLSLSMELSLPQDPRQHEPPESQFDLFARAMDSAIEARNIMWTSMLPCLSDDITQHLRSQAHGRFLTMMPSAKAPDLVARATSEDRIQLAQNLLGVIEAIISGQPPSKSAQLTSTLVDKLTDLWDIISVPDASSAAQDAVRKHWLPFLLRFITLHSIYASSSSSSSSDTAAPIAAGSPAVVNKPVSNVAPPPITTTTSNNHEARARIVLVLCGILFALEAQQSLPPRGKLAQQVFDISLLLVDGLPDDVRLHCARNVLAQPGSSARGIGTSDPRIYYLFSAPRPTAADNLVLAHRDRGAVPLSAAARGLAAMYGIGPTLQERYSHFALRRWEALSEPTPNVGDNDTSLSLGLFEAIKIQ
Length1541
PositionKinase
OrganismCordyceps militaris (strain CM01) (Caterpillar fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Cordyceps.
Aromaticity0.06
Grand average of hydropathy-0.213
Instability index45.37
Isoelectric point9.00
Molecular weight169508.69
Publications
PubMed=22112802

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28080
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     256.44|      85|     122|      53|     173|       1
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   20-  135 (113.36/82.03)	VPPRAQP..RAPsgsaLQAHQRGlSSSYMPPlspvRKDDHHSQPT..DPTDAsttssqastasrhgatPRRTAGSKLRiELSND...EGLTPGPATDSPLGTpsllSHSAAlDSSTDASGHGS
  148-  243 (143.09/84.11)	IPPMPMPrrRAP....LQRFVPS.NKTAAPPtallKRDSKPKQYTieVPPPA................PRYLSTNKPD.TLHRDpfnKGLFSGNADFFPWNG....RHHED.EWSTEAIQKGT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.56|      94|     122|    1014|    1135|       2
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 1031- 1133 (140.45/105.52)	DAGPPrgAAIYLEELLQLILRPLPKNTPLTAD.................ESYRFVVYQQSAQMEHAKALLLLIRNAVQeySILRSRST..TTTLPlddrtC.QDDVLEAL......RVLVVTNSTAAAD
 1139- 1258 (136.11/63.84)	DLAPE..AAALIRTVAAKLLTPGDTHTSSSFDkilglaneltmpfcqlsLSMELSLPQDPRQHEPPESQFDLFARAMD..SAIEARNImwTSMLP.....ClSDDITQHLrsqahgRFLTMMPSAKAPD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     324.98|     110|     591|     772|     897|       3
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  772-  897 (146.65/140.09)	PPRLDTDVSLHVFTSTRAILEATGDFSMLgEVLRScsrMSNMEVLAACVdtvnVNLQVLLAVGVADDLfALYVER...LKAASCEHGL.VARPLLAALSSlAQRmPNQGDvakNLqqELTQTDRSN.PIDA
 1372- 1486 (178.33/114.47)	PPPITTTTSNNHEARARIVLVLCGILFAL.EAQQS...LPPRGKLAQQV....FDISLLLVDGLPDDV.RLHCARnvlAQPGSSARGIgTSDPRIYYLFS.APR.PTAAD...NL..VLAHRDRGAvPLSA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.48|      32|      53|     679|     710|       4
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  679-  710 (56.09/33.96)	LPIYCIPEDRKTDRANLLRRAAHYNVADEARD
  734-  765 (53.39/31.97)	LPIKPIPLRKLVRRINISSFALKSAVGTHLRN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.27|      51|     184|     305|     356|       6
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  305-  356 (84.31/48.45)	DTKREVwLKDLANPTIS.LRRLSRTIPHG.IRGRTLLD..QCLNKNVPTE.RAIWLA
  487-  542 (71.96/36.21)	DPDRDI.LMPLSNQLVSlLKTLVAKNPESfIQPLQWFKyrECLSAFLPTDaRALQQA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.54|      26|     186|     436|     481|       7
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  454-  481 (41.34/55.30)	LIAQicWTDILRS..RKPGRRLVFALLNHL
  978- 1005 (40.20/13.21)	LISD..WVSHIRSlkERPALRELLPLLVSL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.97|      13|     105|     262|     278|      11
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  262-  274 (19.80/19.03)	SLKQKTGLNALST
  282-  294 (22.17/ 7.83)	QRRNRGQITAPST
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28080 with Med12 domain of Kingdom Fungi
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