<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28077

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMFDRECLCASFQRAKKKNGCGTWSTPQTSCLVYQAAGLFTKRFDSPTHLRLRPPPDAAIQPPQPLAVATITPFRHDATTPPRTSSILPPRSKANPVPAVLFSSLLRFVFVARPRQRDEAAYDKTRDTIRRPFWCQSPIDSLARQSAPCGPSPAYSLTVIRNFFSNLQRRLRPIDGNPLQSTHPDSMAAANAAPTGPTTLPTPAHSVTGSISHQSDAAMADEFPHKRKRPLDDVGERDHKKVQYDHRLGIEDLHLDVGPKYMLLQKTYEDQFPLLTGDLYEQFDLADLAAEVAREKPNGEKNALRKTYKGHIKRLGVAGHFDVQKKKEDAPSDFMAMLQVPDLEWNVHQVKGREIGDGLSEATLNGLARAMTMSKGPIPRSVWDTSVLGDMAPHNGNINTTNGESSKAAGPATARATAPNTPAATTPSATMATAADRPRGSLPPGADPLRPRRNIKKRTYGDSSYEGYGEGFPDDDAGADTGYSTGEGEGGQKRRKKVKTVTTATEGASFTNGMQQNSGTTPPFPPVRQHSYGPGMVGA
Length538
PositionHead
OrganismCordyceps militaris (strain CM01) (Caterpillar fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Cordycipitaceae> Cordyceps.
Aromaticity0.07
Grand average of hydropathy-0.676
Instability index50.93
Isoelectric point9.36
Molecular weight58514.14
Publications
PubMed=22112802

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28077
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.62|      28|     116|      41|      72|       1
---------------------------------------------------------------------------
   43-   72 (48.69/34.34)	FDSPThlRLRPPPDAAIQPPQP..LAVATITP
   75-   93 (27.09/ 7.61)	HDATT.....PPRTSSILPPRS..KA......
  169-  193 (29.84/11.72)	.......RLRPIDGNPLQSTHPdsMAAANAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.50|      35|      65|     234|     298|       2
---------------------------------------------------------------------------
  207-  259 (46.67/76.37)	TGSISHQSD.AAMADEFphKRKRPlddvgerdhkkvqydH..RLGIEDlHLDVGPK
  275-  325 (45.84/28.91)	TGDLYEQFDlADLAAEV..AREKP..ngeknalrktykgHikRLGVAG.HFDVQKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.44|      43|     323|     112|     155|       3
---------------------------------------------------------------------------
  112-  155 (76.86/44.60)	RPRQRDEAAYD..KTRDTIRRPFWCQSPIDSLArQSAP...CGPSPAYS
  436-  483 (67.58/34.75)	RPRGSLPPGADplRPRRNIKKRTYGDSSYEGYG.EGFPdddAGADTGYS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28077 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPRSVWDTSVLGDMAPHNGNINTTNGESSKAAGPATARATAPNTPAATTPSATMATAADRPRGSLPPGADPLRPRRNIKKRTYGDSSYEGYGEGFPDDDAGADTGYSTGEGEGGQKRRKKVKTVTTATEGASFTNGMQQNSGTTPPFPPVRQHSYGPGMVGA
2) LRPIDGNPLQSTHPDSMAAANAAPTGPTTLPTPAHSVTGSISHQSDAAMADEFPHKRKRPLDDVGERDHKKVQ
377
170
538
242










Molecular Recognition Features






MoRF SequenceStartStop




1) KRRKKVKTV
492
500