<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28067

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWNGLSQDSHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDTLEWERTQLWSLTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDDSNLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSNAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNFMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAVPPQALNSGSPAPQSTQVPASLPVTQ
Length1367
PositionTail
OrganismCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Cricetulus.
Aromaticity0.10
Grand average of hydropathy-0.003
Instability index46.36
Isoelectric point6.84
Molecular weight156265.94
Publications
PubMed=21804562

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28067
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.57|      19|     127|     905|     923|       1
---------------------------------------------------------------------------
  905-  923 (40.45/27.44)	KENSPEHWLQNDWHTKH.MN
 1001- 1015 (22.19/11.37)	....PVTYLYNTLHYYE.MC
 1035- 1054 (32.93/20.82)	KDNRPQGWCLSDTYLKHaMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.80|      72|     262|     522|     613|       2
---------------------------------------------------------------------------
  446-  520 (119.61/77.91)	PIP....HSLKLHHEF.LQQSLRNKSLQMNDYK..IALLCNAYSTNSEcftLPMGALVETIYGNGIMRVPLPGTSCLASASI
  522-  600 (104.19/114.43)	PLPmnllDSLTVHAKMsLIHSIATRVIKLAHAKssVALAPALVETYSR...LLVYMEIESLGIKGFISQLLPTVFKSNAWGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.61|      24|      89|    1067|    1092|       3
---------------------------------------------------------------------------
 1067- 1092 (44.03/33.53)	YYCKLIGRLVDTMAgkSPGPFPNCDW
 1160- 1183 (43.57/26.47)	YWIVLHDRIVSVIS..SPSLTSETEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.26|      29|     262|     971|    1000|       4
---------------------------------------------------------------------------
  971- 1000 (48.81/37.02)	IHRFL..eLLPVSKSLETLL..DHLGG..LYKFHDR
 1227- 1262 (37.45/22.69)	IPKFLtevLLPVVKTEFQLLyvYHLVGpfLQRFQQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.05|      40|     377|     924|     964|       5
---------------------------------------------------------------------------
  189-  224 (45.44/23.68)	..KLYPEgKLPHWL..LGNLVSDFVDTFRPTARI..NSICGR..
  924-  964 (72.57/46.99)	YHKKYPE.KLYFEG..LAEQVDPPVPIQSPYLPIYfGNVCLRFL
 1299- 1332 (50.03/26.81)	YHMKY.....MFTGdsVKEQVEKIICNLKPALKLR.....LRFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.68|      27|     377|     720|     787|       6
---------------------------------------------------------------------------
   29-   55 (49.29/15.31)	TPEDEKTKLISCL.AAFRQFW..NGLSQDS
  723-  752 (43.39/86.17)	TPHNWASHTLSCFpAPLQAFFkqNNVPQES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28067 with Med23 domain of Kingdom Metazoa
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