<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28063

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLNYRQNSLGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRYPATTQYQHIWTLLSQLEELLVHWMWPSFSA
Length251
PositionKinase
OrganismCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Cricetulus.
Aromaticity0.08
Grand average of hydropathy-0.710
Instability index51.07
Isoelectric point9.73
Molecular weight27859.95
Publications
PubMed=21804562

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28063
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.67|      13|      54|      44|      56|       1
---------------------------------------------------------------------------
   44-   56 (26.44/10.48)	YTQNQPLPAGGPR
  100-  112 (26.23/10.34)	YRQQQPTVPQGQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.11|      26|     134|      57|      83|       2
---------------------------------------------------------------------------
   57-   83 (47.33/21.04)	VDPYRPvRLPMQKLPT......RPTYPGVLPTT
  169-  189 (39.18/13.76)	VPP....SYSSQ..PY......QSTHPSTNPTL
  190-  218 (36.60/12.42)	VDPTRH....LQQRPSgyvhqqAPTYGHGLTST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.97|      26|     107|     115|     140|       3
---------------------------------------------------------------------------
  115-  140 (47.30/24.20)	QQLQAKIQSQ...GMLGQSS...VHQMTPSSS
  219-  250 (41.67/20.58)	QRYPATTQYQhiwTLLSQLEellVHWMWPSFS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28063 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSY
2) MQDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLNYRQNSLGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTTVM
3) QHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQ
90
1
160
141
88
219










Molecular Recognition Features






MoRF SequenceStartStop




NANANA