<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28045

Description Mediator of RNA polymerase II transcription subunit 12-like protein (Fragment)
SequenceFAVFQDESSNHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTESGVGDEGQKARKSKQEVFPTPETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFFPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVNALKNDDFNMRGLRRDGNAEDAWATSQNSKSYGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPSSGSVAEMNNLLDNIAKATIEVFQQSADLNNNAPSSGISLFNPNGIGSADTSSTRQNGIKTFLRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDTKARQMMHEALQLRLNLVGGMFDTVQRSTQGTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVVKYEEQHHFLLYHTHTMPKPRSYYLEPLPLPPEEEEEEPSSPVSQEPERKSAELSDQGKTTADEEKKTKGRKRKTKSSSRIDTMPQGYTMYGTQMPLQQAAQQQSGGVVLSPSYNSRAYPAAHSSPALMERLRQLQQQPSGYVQQQASPYLQPVAGSQRLNHQALQQSPLVGGGIDAVLTPAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQVWGREVRAMPSLPVVQTQSSRNEQTL
Length1225
PositionKinase
OrganismCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Cricetulus.
Aromaticity0.06
Grand average of hydropathy-0.363
Instability index55.81
Isoelectric point7.71
Molecular weight136500.13
Publications
PubMed=21804562

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28045
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     275.55|      93|     380|     655|     771|       1
---------------------------------------------------------------------------
  494-  601 (134.51/81.31)	FNMRGLrrdGNAeDAWATSQNS.KSYGKSISIeTANLreYARyvLRTICQ...QEWVGEHcLKEPERLCTDKELILDpvlsnMQAQKLLQLIC.YP..HGIKECTEGDNLQRQHI
  672-  771 (141.03/109.09)	FNPNGI...GSA.DTSSTRQNGiKTFLRGVWL.VAPL..IAR..LPTSVQgrvLKAAGEE.LEKGQHLGSSSKKERD.....RQKQKSMSLLSqQPflSLVLTCLKGQDEQREGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.20|      11|      28|     413|     423|       2
---------------------------------------------------------------------------
  413-  423 (22.61/14.08)	PGARMTC.RLLL
  443-  454 (18.59/10.19)	PGIRSSCdRHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     154|     170|       3
---------------------------------------------------------------------------
  154-  170 (22.97/19.38)	LLLKSSSLAGSYtTGLC
  184-  199 (29.21/19.52)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     282.62|      92|     103|     944|    1045|       4
---------------------------------------------------------------------------
  944- 1045 (144.29/122.60)	D.KKQARGLQVSTKQKvspwdlfeGQKNPAPLSWAWFGTvRVDRKVVKYEEQHHFLL...YHTHTMPKPRS.....YYLEPLPLPPEEEEEEPSSPVSQePERKSAELSDQ
 1051- 1151 (138.34/92.14)	DeEKKTKGRKRKTKSS........SRIDTMPQGYTMYGT.QMPLQQAAQQQSGGVVLspsYNSRAYPAAHSspalmERLRQLQQQPSGYVQQQASPYLQ.PVAGSQRLNHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.44|      22|      31|     209|     239|       5
---------------------------------------------------------------------------
  209-  233 (33.99/41.85)	SECSSPERCIlaYlYDLYVSCSHLR
  242-  263 (39.44/19.97)	SACSKVKQTI..Y.NNVMPANSNLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.06|      11|      31|      22|      32|       7
---------------------------------------------------------------------------
   22-   32 (20.75/14.79)	GVGKERDEARH
   54-   64 (20.30/14.29)	GVGDEGQKARK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.12|      28|     489|     338|     375|      10
---------------------------------------------------------------------------
  336-  368 (44.13/35.72)	S.....SEWLGVLKALCCSSnhvwgFNDVLCTVDVSDL
  369-  401 (40.99/32.28)	SfhdslATFIAILIARQCFS.....LEDVVQHVALPSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28045 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RSYYLEPLPLPPEEEEEEPSSPVSQEPERKSAELSDQGKTTADEEKKTKGRKRKTKSSSRIDTMPQGYTMYGTQMPLQQAAQQQSGGVVLSPSYNSRAYPAAHSSPALMERLRQLQQQPSGYVQQQASPYLQPVAGSQRLNHQALQQSPLVGGGIDAVLTPAHPNLPSVPLPQDPMRPRQPQVRQQQR
1009
1196










Molecular Recognition Features






MoRF SequenceStartStop




1) RLLQVWGREVR
2) YYLEPLPLP
1196
1011
1206
1019