<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28043

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPTPGAAGIGMPPRGPGQSLGGMGGLGAMGQPMPISGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQFQQQQAALQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQHLQQQQQQHLIKLHHQSQQQQIQQQQLQRMAQLQLQQQQQQQQQALQAQPPMQQPPMQQPPPPPSQALPQQLQQMHHPQHHQPPPQAQQSPVAQNQPPQLPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQQQAAVQTAQAAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSISLGGQPTAQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIVSPVVCSRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLEISVPADYPAQSPMWIDHQWQYDANPFLQSVHQCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length781
PositionTail
OrganismCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Cricetulus.
Aromaticity0.03
Grand average of hydropathy-0.648
Instability index87.38
Isoelectric point9.27
Molecular weight85600.34
Publications
PubMed=21804562
PubMed=23929341

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28043
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     175.22|      41|      63|     179|     227|       3
---------------------------------------------------------------------------
  179-  221 (71.21/15.47)	QQQQQQQQQQF.QA....QQNAMQQQ..F.....QAvvQQQHLQQQQQQHLIKLH
  243-  283 (66.01/10.93)	QQQQQQQQQAL.QAqppmQQPPMQQP..P.....PP..PSQALPQQLQQ....MH
  484-  529 (38.01/ 7.62)	SPVTARTPQNFsVP....SPGPLNTPvnPssvmsPA....GSSQAEEQQYLDKL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.91|      40|     138|     308|     347|       4
---------------------------------------------------------------------------
  316-  364 (57.02/14.46)	LVSQAQALPG........PMLYAAQQQLKFVRAPMVVQQPqvqPqvqqvqPQV.....QQ...QA
  399-  441 (48.98/11.35)	PTSTMSAGPSssislggqPTAQVSQSSLTMLSSP....SP...G......QQV.....QT....P
  566-  613 (52.91/12.87)	LTDPSKRCPL........KTLQKCEIALEKLKNDMAVPTP...P......PPPvlptkQQdlcQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.67|      22|      22|      95|     116|       5
---------------------------------------------------------------------------
   81-   98 (26.99/ 9.27)	....PMNALQSLTGGPTPGAAG
   99-  120 (44.92/21.45)	IGMPPRGPGQSLGGMGGLGAMG
  442-  456 (26.77/ 9.12)	QSMPP..PPQP...SPQPGS..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.20|      18|      22|     675|     692|       6
---------------------------------------------------------------------------
  675-  692 (32.82/19.62)	VARLDPKFLVNLDPSHCS
  700-  717 (32.38/19.25)	ICKLDDKDLPSVPPLEIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.74|      10|      22|     617|     626|       7
---------------------------------------------------------------------------
  617-  626 (17.75/11.23)	AVLA....NIRSPV
  638-  651 (13.98/ 7.07)	AMMAihgpPIVSPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.95|      11|      27|     739|     749|      10
---------------------------------------------------------------------------
  739-  749 (23.73/18.08)	NPFLQSVHQ.CM
  767-  778 (19.22/12.87)	NTWAQSIHQaCL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28043 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPTPGAAGIGMPPRGPGQSLGGMGGLGAMGQPMPISGQPPPGTSGMAPHGMAVVSTAT
2) QPQVQPQVQQVQPQVQQQAAVQTAQAAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSISLGGQPTAQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQALQAQPPMQQPPMQQPPPPPSQALPQQLQQMHHPQHHQPPPQAQQSPVAQNQPPQLPPQSQSQPLVSQAQALPG
70
346
246
148
531
325










Molecular Recognition Features






MoRF SequenceStartStop




NANANA