<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28039

Description Mediator of RNA polymerase II transcription subunit 26
SequenceMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLIEPVHQNEVALRALAGAAGSANGGAHNCRSEVGVASTPKSIHDLKNRNDIQRLPGERLDRLGSRKRRGDQRDLGHPGPPHKVPKATPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDSSRLEPSDNEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLDRADEPPGPPHPRGTSRCSFSPRNSRHEGSFARQRSSYIAKGSVSSPSPRPQPLDTTQVPSPLPLAQPSTPPVRRMELLSSAESPVHWPEQPEGHPRLTGPACRVGLSPDSSKVDSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVPTEQPPRTEQDQQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMAEYLKQEESSRRGARQPHVLLPLPTPTDLPGLTREITQDDLDRIQAQKWPGVNGCEDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length558
PositionUnknown
OrganismCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Cricetulus.
Aromaticity0.03
Grand average of hydropathy-0.889
Instability index61.89
Isoelectric point9.34
Molecular weight61208.99
Publications
PubMed=21804562

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28039
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     441.86|      78|      78|     140|     217|       1
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   89-  138 (54.31/17.65)	.........................GVASTPKSI.HDLKNRND..IQrlP.G..ERLDRLGSRKR..................RGDQRDL.......GHPGPPHKV
  140-  217 (135.47/55.27)	KATP....DPLVPNASPL....PTNGISGSPESLPSPLDGSGH..LG..PDS..SRLEPSDNEKH..STKIPVNAV.....RPRPSSPGL.......GKPPVPCLQ
  219-  290 (90.32/34.34)	KA.............AQL....DR...ADEPPGPPHP.RGTSRcsFS..PRN..SRHEGSFARQR..SSYIAKGSVsspspRPQPLDTTQ.......VPSPLPLAQ
  292-  379 (87.27/32.92)	STPPvrrmELLSSAESPV..hwPEQP.EGHPR.LTGPACRVG...LS..PDS..SKVD.SDAASSggSDSKKKKRY.....RPRDYTVNLdgqvaeaGVKPVR.LK
  382-  453 (74.49/27.00)	KLTF....DPMTRQIKPLtqkePVRADSPVPTEQPPRTEQDQQ..EA..KASlqSPFEQTNWKEL..SRNEIIQSY.....LSRQSS...................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28039 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LRALAGAAGSANGGAHNCRSEVGVASTPKSIHDLKNRNDIQRLPGERLDRLGSRKRRGDQRDLGHPGPPHKVPKATPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDSSRLEPSDNEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLDRADEPPGPPHPRGTSRCSFSPRNSRHEGSFARQRSSYIAKGSVSSPSPRPQPLDTTQVPSPLPLAQPSTPPVRRMELLSSAESPVHWPEQPEGHPRLTGPACRVGLSPDSSKVDSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVPTEQPPRTEQDQQEAKASLQSPFEQTNW
2) QSSLLSSSGAQTPGAHHFMAEYLKQEESSRRGARQPHVLLPLPTPTDLPGLTREITQDDLDR
67
451
435
512










Molecular Recognition Features






MoRF SequenceStartStop




1) RLKERKL
2) SKKKKRYRPRDYTVNLD
377
349
383
365