<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28035

Description Cell division cycle 2-like protein kinase 6
SequenceMSACREIAHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQPQQQNPHQQPTAPPQQTAAPTQAPPPQQSSAQTNGTAGGAAAAAAGAGAGLQHSQDSSLNQVPPNKKPRIGPSGASSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYASSQQSTQYHPSHQTHRY
Length404
PositionKinase
OrganismCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Cricetidae> Cricetinae> Cricetulus.
Aromaticity0.08
Grand average of hydropathy-0.659
Instability index60.93
Isoelectric point8.82
Molecular weight45183.57
Publications
PubMed=21804562

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-KW

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process
cell division	GO:0051301	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28035
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.73|      16|      17|     222|     237|       1
---------------------------------------------------------------------------
  222-  237 (27.37/14.67)	DPTKRITSEQALQDPY
  241-  256 (29.36/16.25)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.07|      35|      37|     327|     363|       2
---------------------------------------------------------------------------
  291-  319 (34.19/11.34)	.QTAAPT.....QAPPPQQSSAQTNGTAGGAAAAA.....
  329-  363 (60.86/28.37)	SQDSSLN.....QVPPNKKPRIGPSGASSGGPVMPSDYQH
  364-  402 (48.01/16.60)	S.SSRLNyqssvQGSSQSQSTLGYASSQQSTQYHPSHQTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      41|      54|      68|       3
---------------------------------------------------------------------------
   54-   68 (26.77/17.32)	DLKPANILVMGEGPE
   92-  106 (28.67/19.00)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28035 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQPQQQNPHQQPTAPPQQTAAPTQAPPPQQSSAQTNGTAGGAAAAAAGAGAGLQHSQDSSLNQVPPNKKPRIGPSGASSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYASSQQSTQYHPSHQTHRY
256
404










Molecular Recognition Features






MoRF SequenceStartStop




1) LNYQS
2) TLGYAS
3) VPPNKKPRIGP
368
383
337
372
388
347