Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MSNGQFIQQRLDSLNDIDSSIVSLLGYMSDIFDRYSTPSNNSDDAKDTIETQTRLIYQTLSDIAINLRKEVKIMDDNTGVFDKNEDQVMILPIPVDQKNTALGKRRLNEEIDLLTHLIPQEPTEDQKFKPEPETVEEESVKEEPVEEEPVEEEPVKEEQPEEKNGVDDTDEPDPIVKPEADVETFGISDVEMEE |
Length | 194 |
Position | Head |
Organism | Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Yamadazyma. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.873 |
Instability index | 60.19 |
Isoelectric point | 4.06 |
Molecular weight | 22140.02 |
Publications | PubMed=21788494 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP28031 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 81.74| 27| 46| 8| 34| 1 --------------------------------------------------------------------------- 8- 34 (46.49/35.05) QQRL..DSLNDIDSSIVSLLGYMSD...IFDR 52- 83 (35.25/25.01) QTRLiyQTLSDIAINLRKEVKIMDDntgVFDK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 60.73| 19| 20| 152| 170| 2 --------------------------------------------------------------------------- 152- 170 (31.66/15.18) EEPVKEEQPEEKNGVDDTD 173- 191 (29.07/13.39) DPIVKPEADVETFGISDVE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 32.15| 10| 20| 118| 132| 3 --------------------------------------------------------------------------- 118- 132 (13.92/14.68) IPQEPTEDqkfkpEP 140- 149 (18.23/ 6.62) VKEEPVEE.....EP --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EPDPIVKPEADVETFGISDVEMEE 2) IVSLLGYMSDIFDRYST 3) PVKEEQPE | 171 21 154 | 194 37 161 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab