<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28022

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDSSTVVVGAELPHVTSNIIPLSSVLKFYCHEAYKQLNTMVENLSITRNKETDVTRKKKLLTLIVGLRQDFIKIYALVKWASKAQDVGKLIDLLNWFRTQEFYFEQLALGLNELNGFSGAKLPNSDLTTSMEVLIKGRPQLPSYNLIKNPPISSQKILKVLQDLNLALTARIALNDNIPSELLVNHQVKDGRIVFKLDKKYEACVTVANDLIIESDEEYSRSPYFLIDFHFAFGIDDDNVLKSNLPTPLPQSFWTKLEKQGNSVLLSSNLQGLYRFLNNFTKKFKFNLIYQQQLKSLNDLKWKNLKYKYADNKILINYWNNPSNTIEITLNEDFEIEFKWFKNNEIMTNLQDISINNDEFNIEYLLNLILNKHCGILASSISRTNPTFFKLINPYQVLIKLTNSKPSILSIDSLTGNFYFTEPNAAQAHITKRINSFNYNGSESSLIQYIHNKLIELKLDTISSEIKNKLITIEWISNHIINLKENELRKLDKDLVGTAFNIQYFKCKNWPSSWFLISVVDERDFNIDWFVSRIKSIKGEWKLEWVTNLGLIDSQLNFEFFNNLSVVCSNKIIDNMLTQELTIKNVKFIELAANHSLLTQFHMESNSGKRNYELMILIYNGGEYLPVKNSSNSLILKIELVNNKESKLIKVRLMSKLKLDSSKFNNLNLDNIKILERGGQQFIEIFQEINLGNNELNLDVNILEGVFGSLNKLNYLITLMNEVIENNVEVLEFNQCIKIKINEVFKQVYIEVPEKGMRNYHYRYDENEANDIKLIINYINKSISYDKPYSLLSVINYFNQIMPLIQGIRKLRTHVDTKAASHKLSNGLCKLNFDLKFVNLNNLQLLFGLNYYNPNNTKKVQRDKIILTMRFKLNKFRVGNQLEMNLSLLDNINIKNLKYKKLFEMIFKSLNKYEDAVNLNYDFIVGMPVVSEFLMDVGNCFLEYVEGE
Length948
PositionTail
OrganismCandida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Yamadazyma.
Aromaticity0.11
Grand average of hydropathy-0.216
Instability index33.16
Isoelectric point8.60
Molecular weight110114.84
Publications
PubMed=21788494

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28022
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.93|      20|      20|     713|     732|       2
---------------------------------------------------------------------------
  685-  704 (28.48/16.19)	IFQEINLGNNELNLDVNILE
  713-  732 (31.44/18.83)	LNYLITLMNEVIENNVEVLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     697.63|     177|     182|     320|     500|       3
---------------------------------------------------------------------------
  320-  500 (281.47/184.36)	NNPSN..TIEITLNEDFEIEFKWFKNNEiMTNLQDISINNDEFNIEYLLNLIlNKhcGILASSISRTNP.TFF.........KLI.NPY.QVLIKLTNSKPSILSID.SLTGNFYFTEPNAAQAHITKR.....INSFN...................YNGSESSLIQYIHNKLI...ELKLDTISSEIKNKL.ITIEWISN......HIINLKENELRKLDKDLVGTAF
  509-  682 (205.58/121.94)	NWPSSwfLISVVDERDFNID..WF.....VSRIKSI...KGEWKLEWVTNL......GLIDSQL...NF.EFFnnlsvvcsnKIIdNML.TQELTIKNVKFIELAANhSLLTQFHM.ESNSG.....KRnyelmI..LI...................YNGGEYLPVKNSSNSLI....LKIELVNNK.ESKL.IKVRLMSKlkldssKFNNLNLDNIKILERG..GQQF
  734-  910 (210.58/125.11)	N...Q..CIKIKINEVFKQVYIEVPEKG.MRNYHYRYDENEANDIKLIINYI.NK.......SISYDKPySLL.........SVI.NYFnQIM.......PLIQGIR.KLRTH...VDTKAASHKLSNG.....LCKLNfdlkfvnlnnlqllfglnyYNPNNTKKVQ..RDKIIltmRFKLN..KFRVGNQLeMNLSLLDN........INIKNLKYKKL.FEMIFKSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.64|      12|      17|      69|      80|       4
---------------------------------------------------------------------------
   69-   80 (22.51/13.91)	QDFIKIYALVKW
   85-   96 (22.13/13.55)	QDVGKLIDLLNW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28022 with Med14 domain of Kingdom Fungi
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