<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28019

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMSEDLISALYPPPPLFYKYFTSENLQKLKECQSDDKPIEGELKFLVPPSQPPGTHYRGYGNIWSFEDKLPKLSEMGYTQLYEDTDDQSAGSNKITELHKLMKSLLVNFIELIGIMHINPSEFHTKIEDLKVILINMNHILNSYRPHQSRESLIMLLKQRINEKKEEINSIDTKMSDIKDKLLTLINFSDVKLIQPDVKSDTLNTDQIKEKILYKLLKDI
Length219
PositionMiddle
OrganismCandida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Yamadazyma.
Aromaticity0.08
Grand average of hydropathy-0.494
Instability index53.63
Isoelectric point5.72
Molecular weight25456.10
Publications
PubMed=21788494

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28019
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.50|      20|      24|     112|     135|       1
---------------------------------------------------------------------------
  116-  135 (34.70/26.18)	HI.NPSEFHTKIEDLKVIL...IN
  138-  161 (25.80/ 9.26)	HIlNSYRPHQSRESLIMLLkqrIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.49|      18|      27|     164|     182|       3
---------------------------------------------------------------------------
  164-  182 (26.02/20.00)	KEEINSiDTKMSD.IKDKLL
  194-  212 (26.46/15.39)	QPDVKS.DTLNTDqIKEKIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28019 with Med7 domain of Kingdom Fungi
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