<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28018

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMYEYNSRSEKNSILTDRMLPRKEQNNLSVPISRVGSSARLNQLNSPGNFNSFPSTPNAYQVSSLNPIRASSRSVPPKSIQDQQFEEKFNNLEIVQIVRDFEEQLANLSRKASSFEADGLEDTISSLVDINQQIIEQIDQLGKHKQLGETIQALEDEKVGLADRSRSILKSLIEFRSELNKLPSLPTNKTEPQDSLADMDIDEVLKYGMKLSKFTKVPPSASGMVYQIHPNNFIWPAEDSLRRGMLAMSSLKGDEIIQKELGIKGNDNVPTEEMEDIETAGNEDTFKKPAPKGANHNKSSDATIAAAAPTLNLDLFDPDDEDDSD
Length324
PositionMiddle
OrganismCandida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Yamadazyma.
Aromaticity0.05
Grand average of hydropathy-0.692
Instability index54.60
Isoelectric point4.73
Molecular weight36085.77
Publications
PubMed=21788494

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28018
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.79|      14|      52|     201|     217|       1
---------------------------------------------------------------------------
  172-  185 (23.18/10.49)	IEFRSELNKLPSLP
  204-  217 (23.61/10.56)	LKYGMKLSKFTKVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.79|      23|      53|      87|     109|       2
---------------------------------------------------------------------------
   87-  109 (37.47/25.12)	KFNNL.EIVQIVRDFEEQLANLSR
  122-  140 (21.62/11.72)	TISSL...VDINQQIIEQIDQL..
  142-  165 (29.70/18.55)	KHKQLgETIQALEDEKVGLADRSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28018 with Med4 domain of Kingdom Fungi
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