<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28015

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMRPIERLLHLSNRRNVSDKQFLHLFKQLDGKTPVTAGEFVDLLEDSSNERYLTVVSLIKLNSFWKAVAKLPTNQQVRILRKYHLKIHLITDVEAFLPIFVEYSEHVLDQNNEELLNELIFNWGTLISKFSLKDKEVVKVFVTKLMSFLNANNYTKQFEYCSNKFTTSKQNLTIQPRLNNLNLNVNSKNHSSYESIKIFFYFNEMFKSYQVPDNEKLFKNFNEVFKGDCYKLIYSMFNGIYLSEQAKQPSFVKNNWLNFLSSRVPKLILLYKVDNLEDTINKAFENFDNFDKINTNLKQYFIKSLIFNKILSIKSFHRFFPNEGKVNQQTLIHEMSNVNSSENFQDNLNDKLYSINCEFISIDESNLMEYLDTTINKVEFSMQKQVDLISTMKNMMDLLVDEQSLEKLNRLLLILLKSPKLFQVFMFNLSDREIIFKLIKLLDNDSFKLNDNNEGSFQEFFSYFGVLLLFIMQCSEYINMDFNMKNSFTSTYLHNYNLNYTNLTPVFNEEVENDKTIASNYNSLINDWINSLFDEAEGLSDDLIKSIDVKQVYQLIPLIYQQAVIAFINGKINLKILNNGLDYLSQNFLLPCSVSIVKWILSKISLKNKNLNNYLTVLKEIMKIISKVKDESSNELKLTAEVVLNFIIQLAVSELRYLNIPGNLINNDMLTEQIRLSEAPAKVNSLCFEVFETNLIKALNGNEADFELINYYVYSSDSMIKDLLITLNTSNTSIKTNNENLKLVIDFVIFINLNRTIKSEPVKQFWINKFSSLKIDTSKYDFNTTFEKNIDYHFSTIFNVDGNDDGNEDLEEGNADELFEPISFDYCLNEMAKASNDLTEFLYIVQRFQDLSENKSFLSSINLIHTKLLNDLKSFQC
Length876
PositionTail
OrganismCandida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Yamadazyma.
Aromaticity0.12
Grand average of hydropathy-0.216
Instability index20.63
Isoelectric point5.30
Molecular weight102361.91
Publications
PubMed=21788494

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28015
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.13|      22|      23|     768|     790|       1
---------------------------------------------------------------------------
  768-  790 (33.51/23.87)	KFSSL.KIDTSKyDFNTTFEK.NID
  792-  815 (30.62/16.19)	HFSTIfNVDGND.DGNEDLEEgNAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.02|      28|      32|     554|     583|       2
---------------------------------------------------------------------------
  554-  583 (43.65/30.51)	LIPLiyQQAVIAFINGKINLK..ILNNGLDYL
  588-  617 (44.38/24.57)	LLPC..SVSIVKWILSKISLKnkNLNNYLTVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.05|      13|      15|     844|     856|       3
---------------------------------------------------------------------------
  844-  856 (22.11/12.31)	VQRFQD..LSENKSF
  860-  874 (16.95/ 7.68)	INLIHTklLNDLKSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     530.81|     114|     116|     194|     307|       4
---------------------------------------------------------------------------
   75-  183 (113.83/52.11)	QVRIL..RKYH.............L..KIHLITDVEaflPIFVEYSEhVLDQNNEELLNELiFNwGTLI......SKfSLKDKEVVK....VF....VTKLM........SFLNANN....Y..TKQFEYCSNkFTTSKQN.L......TiQPRLNNLNLN
  194-  307 (195.44/94.85)	SIKIF..FYFNE...........MF..KSYQVPDNE...KLFKNFNE.VFKGDCYKLIYSM.FN.GIYL......SE.QAKQPSFVKNNWLNFLSSRVPKLI........LLYKVDNLEDTI..NKAFENFDN.FDKINTN.L......K.QYFIKSLIFN
  311-  427 (98.77/44.23)	SIKSFhrFFPNEgkvnqqtliheM.....SNVNSSE...NFQDNLND.........KLYSI..N.CEFI......S........IDESNLMEYLDTTINKVEfsmqkqvdLISTMKNMMDLLvdEQSLE.......KLNRL.LlillksP.KLF.QVFMFN
  433-  533 (122.77/56.80)	...II..FKLIK...........LLdnDSFKLNDNN...E..GSFQE.FF.........SY.F..GVLLlfimqcSE.YINMDFNMKN...SFTSTYLHNYN........LNY..TNLTPVF..NEEVEN.DK.TIASNYNsL......I.NDWINSL.FD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.51|      16|      20|     730|     748|       5
---------------------------------------------------------------------------
  709-  724 (24.13/14.46)	NYYVYSSDSMIK...DLLI
  730-  748 (21.86/20.99)	NTSIKTNNENLKlviDFVI
  753-  766 (25.53/15.80)	NRTIKS..EPVK...QFWI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.72|      28|     582|      44|      73|       6
---------------------------------------------------------------------------
   44-   73 (43.27/38.62)	EDSSNEryLTVVSLIKLNSFWK.AVAKL.....PTN
  629-  662 (36.45/24.31)	DESSNE..LKLTAEVVLNFIIQlAVSELrylniPGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.00|      15|      15|      10|      24|       7
---------------------------------------------------------------------------
   10-   24 (25.08/17.79)	LSNRRNVSDKQFLHL
   28-   42 (24.92/17.63)	LDGKTPVTAGEFVDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28015 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA