<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28014
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSNHHIIQVKVEDELFNGSKDPFLHNEDDFSVEEIIPKILLERKSFLSLTEEGLQKESEGLSFGIDAVDTEDATETSPSDGGEETKENDSSELDQIHDIKMNLSKNINLALNETSLALDLVSLLLSATKPSLAKSTISPHLAKNVPLGSFSSDRLTPEENAPKNDVNVNKIGQGWKYESLSKIKSLFSNKREELQLQGQKEKVYWNQINKVLSNNEILLKMRDPADKSKSIGVKYGYGDSGSSYHDKGIAILRRNPKTGELTFAPVLESNNKLINKTFKYVKVKILSKVDDEYTLTGQSKFEFNFKDDSAGRLITDIEKARFFIFEEDLFFQLTREARTLINYNVSIIADKIIIEVNNEIIEIETISYDETSEDDTDRLYLAANEQSSQNDLKCQLILNYLKIMLCGYFKYNLNLKQKIPTSFTKFKQNNSHPLILRPLIGHFKHEAYVDKLSTLMAEAMEKYKHKLEFEFIVSKYENIKNLTKIETPFIKSIEKPISRFNLIIKNPVNKKCLKVDVDLTTSEIFVNLILHLKIIRYEKVENLNLNEKGTNVLKLTFSDFTEVDQSVDWSIQKFLAE |
Length | 577 |
Position | Head |
Organism | Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70) (Yeast) (Yamadazyma tenuis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Yamadazyma.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.449 |
Instability index | 38.53 |
Isoelectric point | 5.56 |
Molecular weight | 66073.42 |
Publications | PubMed=21788494
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP28014
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.78| 15| 65| 410| 425| 1
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410- 425 (24.15/18.78) KYNlNLKQ..KIPTSFTK
475- 491 (23.63/13.20) KYE.NIKNltKIETPFIK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 138.58| 43| 65| 268| 332| 2
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8- 52 (66.80/26.26) QVKVEDELFNGSKDPFLHNEDDFSVEEIIPKIllERKSFLSLTEE
286- 328 (71.78/56.32) LSKVDDEYTLTGQSKFEFNFKDDSAGRLITDI..EKARFFIFEED
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