<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28011

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDKQSLTNKHLASLTNTSKLISWSKNGFIAYSSPLASSTNNLYLTYLENINGKTWQLAPPQPINIKLENNFLPEISLVSWSSLNTDLAIADVYGNFYILLAGVGLLDDTTTTTTTTTGRTSPTTFSPSYELTSYNHMEMIYRDIINQDSKSTVNPGASIIAFKWMNIEKAQLMNKPATLVPDSNSPVPNSNNGQFAYTYGASSFPPHGATHPLATKQACVALRQNGQFMLYYQGEHKVEYHKLCVGLTDGISVITKASIGFANDKQIIITAYDSITDTISTYSVVIDWGFLVEAAKRQKVDQHYHTPKEAQKPVKMTVNRIHDMKPAVKFLDDEDDSDEDKMDVDNVKYTIGELVSVDVISANAEKDSKPSVLIGYAYTNQSDHITSIIYRYNITDKLDLVSDAFMELGARKGVVSPSTPTKKSVTLTLMDKITRSGQIRHINTVLNDFYMLIAYMDGKIDVIDLSTWKLVTHSTEQFPPTSISTIFDVGFSFPKIPHTNPLILAVSPNMTSLVYTEVYSDKPNLSLVMVEKTRHTGYSSRDLFTTSVGFAFRHAYTCYTNTCSDDLLVLIQSEIVRLRAKLSETKANSNVDVILDKFVESIITESHKAINFQLDGFSRESVDKLLSNPPLQKLLSLQLVLGEFLGTNSISSDIAWMILNLRSTSFGIMFSLSSIYRQISKKKPSEDSLQDSIARAECIVSLIGNMKWLIDLMVYLNQELLQLSLCKRDEDSKNSRVTIANSIVLPVILSKVPRLFIMYAISSIGKTHEILKKLHKDLNEANKLFTPMKESLNRYFTICDHAPLTLSLFENFLRECDALITKELSTRVTTPGVVLRLEQKLVCRGEITGEMSQIAPYIIERYAANINRELKASDLYFFDVDWLDIGIIRDQSRESSPVLVDSSTSKIAPRLRMQDGYIDALRKITIGGGEIRKCTRCRAVSLVSDPLVFDGSVGPGLWTMVFQRTCLCGSVWVNVNTSNRH
Length981
PositionTail
OrganismSpathaspora passalidarum (strain NRRL Y-27907 / 11-Y1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Spathaspora.
Aromaticity0.08
Grand average of hydropathy-0.124
Instability index37.51
Isoelectric point6.60
Molecular weight109750.43
Publications
PubMed=21788494

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28011
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.96|      41|      42|     658|     699|       1
---------------------------------------------------------------------------
  658-  699 (63.87/44.48)	ILNLRSTsFGIMFSLSSIYRQISKKKPSEDSLQDSIARAECI
  703-  743 (65.09/41.16)	IGNMKWL.IDLMVYLNQELLQLSLCKRDEDSKNSRVTIANSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.05|      41|      41|     853|     893|       2
---------------------------------------------------------------------------
  845-  885 (68.82/39.95)	GEITGEMSQIAPYIIERYAANINRELKASDLYFFDVDWLDI
  886-  926 (66.23/38.20)	GIIRDQSRESSPVLVDSSTSKIAPRLRMQDGYIDALRKITI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.34|      37|      41|     348|     386|       3
---------------------------------------------------------------------------
  348-  386 (56.93/50.53)	KYTIGElvSVDVIS.ANAEKDSKPSVLIGYAYTNQSDHIT
  391-  428 (56.41/42.91)	RYNITD..KLDLVSdAFMELGARKGVVSPSTPTKKSVTLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.88|      13|      30|     187|     199|       4
---------------------------------------------------------------------------
  187-  199 (25.81/17.09)	VPNSNNGQFAYTY
  220-  232 (25.07/16.40)	VALRQNGQFMLYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.51|       9|     288|     203|     213|       5
---------------------------------------------------------------------------
  203-  213 (17.53/17.57)	SFP..PHgaTHPL
  492-  502 (16.97/ 8.78)	SFPkiPH..TNPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.56|      18|     282|     258|     280|       6
---------------------------------------------------------------------------
  258-  280 (26.31/30.43)	SIGFAndkqiIITAYDSITDTIS
  547-  564 (37.24/26.67)	SVGFA.....FRHAYTCYTNTCS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28011 with Med16 domain of Kingdom Fungi
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