<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28003

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNEDINGQDTSKVPPLPHVTTNILPLSSIIHFHTQEAYKQFTTAIDNLAADQSNDVKRKKQFLELIISLRHDFVKLYTLVKWCSNSADVSKLIDLLNWLRQLEFSYDQLLYTMNTEFGNSQFNYGTKLPNSDLITSLQVLYKQRPQLASYGYLRTDNDVVSSEKILEVLKELNLVLTIRFALMNDVELPPRFNNNYEIKDGKCFITIPNEYQLVITTISQTSPFYLIDFKFLFGINQETLSISHNSYTKLPPKSYKKLEKIVNTVFNTSTSTSLTEVYELLHKYSMSFKLYLIAKQIKELMVNSKWRNNIDLNYSIGRNSLILNYWSSHYLSKNYKSFIELGIDRNYNLNYRWFKNGQYQQTDMTEIFIQSQPEDNEEVIIDDDDDEGNDDHPHDLNVDVMLNVIVNKHAELLMSSVFERLAGLLSPEEISQVNSHQLLVKLSHNKSTIFAINPLTGYFYFIDPITIQQAITKKINTAPSTSSKFISEDDLINNIIDQIIQLRLLVYTKEINNKLLTSQWINNDIITLSETELSKLGNSGKCQFYRVKKWPSSWFLINSINGINNSVAWYVARIKSIKGEWKIQWKNKISHDSELNYGFFSGLATICSNMIIDHMIIEELQTKHIKYFKVDADKERKVLAKFGIKEKPSVEGTIYQSLIMIYNDELLPINNSSTSLFLQIQLLSDHKMNLTLFGNLRNLSIIQEDYSQLNLTIIEENFEFKDTVNLSTATMTERNLLSKLFNNLNQFNKLIKILDQLNNNHIQIVSNTINDITINIDGNNLTILLPEESTMCIQLTTTTENSQLRLILEYLNRYLHTTNTSSVIGIIKYLQTINPILNAITTINKLVNKQTFRLSNGLSRLNFDVTLNTLNSIQFIFHISSSTNSKKIIKDKITVNISFKNNKFDKQKRNLVKISLRDNLIDKNLKFKKLFELIFKSINDLEQTKKNDTSVALFKLNYDFLISGNILEELLERIGNSFISYLQLEKS
Length987
PositionTail
OrganismSpathaspora passalidarum (strain NRRL Y-27907 / 11-Y1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Spathaspora.
Aromaticity0.10
Grand average of hydropathy-0.259
Instability index33.73
Isoelectric point7.04
Molecular weight114316.53
Publications
PubMed=21788494

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28003
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.74|      37|     234|     486|     531|       1
---------------------------------------------------------------------------
  486-  531 (50.82/36.27)	ISEDDLINNIIDQIIQL.RLLVYTKEINnklltsqwiNNDIITLSET
  731-  768 (56.92/26.33)	MTERNLLSKLFNNLNQFnKLIKILDQLN.........NNHIQIVSNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.59|      38|     102|      24|      64|       2
---------------------------------------------------------------------------
   24-   64 (56.19/55.78)	LPLSSIIhFHTQEAYKQF..TTAIDNLAADqsNDVKRKKQFLE
  128-  167 (59.40/45.00)	LPNSDLI.TSLQVLYKQRpqLASYGYLRTD..NDVVSSEKILE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     317.96|      85|     401|     185|     291|       3
---------------------------------------------------------------------------
  185-  276 (129.05/90.06)	DvELPPrFNNNyeikDGKC.FITI...P..NEYQLV..ITTISQTSPFYLIDFKFLFGIN..QETLSISHNSYTKLPPKSYKKLEKIVNTVfNTSTSTSLTE
  540-  618 (95.90/48.85)	................GKCqFYRVkkwP..SSWFLInsINGINNSVAWYVARIKSIKGEWkiQWKNKISHDS..ELNYGFFSGLATICS...NMIIDHMIIE
  664-  730 (93.02/53.25)	D.ELLP.INNS....STSL.FLQI...QllSDHKMN..LT...............LFG.N..LRNLSIIQEDYSQLNLTIIEENFEFKDTV.NLSTAT....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.26|      23|      24|     901|     924|       4
---------------------------------------------------------------------------
  901-  924 (34.70/25.72)	N.NKFDKQKRN.....LVKISLrDNLIDKN
  937-  965 (29.56/16.35)	SiNDLEQTKKNdtsvaLFKLNY.DFLISGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.58|      10|      24|     316|     326|       5
---------------------------------------------------------------------------
  316-  326 (17.22/13.15)	IGRNsLILNY.W
  343-  353 (18.36/ 8.80)	IDRN.YNLNYrW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.42|      15|      17|     798|     812|       9
---------------------------------------------------------------------------
  798-  812 (25.14/12.21)	TTENSQLRLILEYLN
  817-  831 (25.28/12.31)	TTNTSSVIGIIKYLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28003 with Med14 domain of Kingdom Fungi
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