<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28001
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MVHQLSLVSSIPHNKYLQTISTLQALTGLVQPQPISTYTLISKPSTVFKPKFEPGKVNQIEQYFMKCITNWRDDSIDISKPILKDGDIVSARRLFRPDDKTERVWTLQISDIPIAGKNQGCCQQTVYESTLVHTHTRIDLNLEDKVKEGKDDFEDFIEIDPPEDSEVDSKKTEDALAEQRRASFLVFLQDLGYEVINQFWIKGIRFFHGDIIIEIFKVLIRDDTTANNSTAERIKLKLLDESNTFQIRVYMNVSKSTDVEQINHGTKELIKLQEFLKNLFILEIPDRIFMDSRVTLTK |
Length | 298 |
Position | Head |
Organism | Spathaspora passalidarum (strain NRRL Y-27907 / 11-Y1) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Spathaspora.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.362 |
Instability index | 32.17 |
Isoelectric point | 5.50 |
Molecular weight | 34454.99 |
Publications | PubMed=21788494
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP28001
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 89.32| 30| 36| 227| 257| 1
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227- 257 (46.69/35.36) NNSTAERIKLK.LLDESNTFQI..RVYMNvSKST
263- 295 (42.63/27.47) NHGTKELIKLQeFLKNLFILEIpdRIFMD.SRVT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 91.03| 30| 30| 53| 82| 2
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47- 81 (48.36/33.55) VfkpkfEPGKVNQIEQYFMKCITNWRDDSIDISK.P
82- 113 (42.67/28.79) I....lKDGDIVSARRLFRPDDKTERVWTLQISDiP
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