<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28000
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSQTQTPFNISTPNSTHQQVTQHPPPDFSQIPTDSLESIRNRLNQIHLSLRKLADQINGHNRHPNKIKLPSYSHFQNQFQVLITQLTSIASILYSNEDLLRNTNVYPVPNFPTSAQEGLLTTLLRKKALPEVDEWTTTALAKSESESAQTSMNLQKYDELAQWCFAKVQELRDEFQFYGFHTVEELDFLETTEGKKEAQEKKELENQREELEIKLTAGNKKGLHPNQVLKFMYQGQI |
Length | 237 |
Position | Head |
Organism | Spathaspora passalidarum (strain NRRL Y-27907 / 11-Y1) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Spathaspora.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.752 |
Instability index | 35.85 |
Isoelectric point | 5.92 |
Molecular weight | 27326.32 |
Publications | PubMed=21788494
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP28000
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.30| 17| 22| 99| 115| 1
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99- 115 (31.02/20.35) LLRNTNVYPVPNFPTSA
123- 139 (29.28/18.86) LLRKKALPEVDEWTTTA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 58.89| 14| 22| 184| 197| 2
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158- 174 (15.86/ 8.48) DELAqwcFAKVQELRDE
184- 197 (23.34/15.42) EELD...FLETTEGKKE
209- 221 (19.68/12.03) EELE....IKLTAGNKK
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