<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27990

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMPSDLPQTPQSPSNTPSSTDISSKNAVSPRINTSLPTPAHSINGSMSTANSAIETSQSIDPLSKRKRDFEDLGDQKQKKVHVEDSRPSIDDLHQDVGKKYLLCRTLHKHQNLNVQQDLYDRFGLNGIAASLARVTADGKKNTVRKTYKGYIKSLGIAGQFDAVKGPEPNQPGSLTSLIDPYGPIGPREGWNQAHVQGKEISRGIEDLLPELKTALTMAKGPVPKERWNQSVLGEISSQIANDPLKAIPAKAKAPMSMPQSTMGVPKQNRGAADIVRPKRTAKKRSYGDSSFEGYGEGYVDDDGGYSTGDGDDRAGGRKRPKKVGSVLYPSNVQANKGKTPTSHGFQGPMRQSYGPGMVGA
Length360
PositionHead
OrganismBotryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytis cinerea)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Botrytis.
Aromaticity0.05
Grand average of hydropathy-0.819
Instability index47.81
Isoelectric point9.56
Molecular weight38773.03
Publications
PubMed=21876677

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27990
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.50|      17|      27|      53|      75|       1
---------------------------------------------------------------------------
   53-   75 (24.49/26.54)	IETSQ.SIDPLskrkrdFEDLGDQ
   82-   99 (26.01/14.29)	VEDSRpSIDDL......HQDVGKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.61|      48|     171|     135|     183|       2
---------------------------------------------------------------------------
  135-  183 (81.30/41.14)	TADGK.KNTVRKTYKgYIKSLGIAGQFDAVKGPEPNQPGSLTSLIDPYGP
  307-  355 (84.31/39.20)	TGDGDdRAGGRKRPK.KVGSVLYPSNVQANKGKTPTSHGFQGPMRQSYGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.61|      34|      34|     186|     219|       4
---------------------------------------------------------------------------
  186-  219 (60.49/36.83)	PREGWNQAHVQGKEISRGIEDLLPELKTALTMAK
  223-  252 (52.26/30.94)	PKERWNQS.VLG.EISSQIAN..DPLKAIPAKAK
  256-  281 (30.87/15.64)	...SMPQSTMGVPKQNRGAADIVRPKRTA.....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27990 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DPLKAIPAKAKAPMSMPQSTMGVPKQNRGAADIVRPKRTAKKRSYGDSSFEG
2) GYVDDDGGYSTGDGDDRAGGRKRPKKVGSVLYPSNVQANKGKTPTSHGFQGPMRQSYGPGMVGA
3) MPSDLPQTPQSPSNTPSSTDISSKNAVSPRINTSLPTPAHSINGSMSTANSAIETSQSIDPLSKRKRDFEDLGDQKQKKVHVEDSRPSIDD
242
297
1
293
360
91










Molecular Recognition Features






MoRF SequenceStartStop




1) RKRPKKVGSVLYPSNVQANK
317
336