<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27988

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSTLPSNHPLSLRPAPNTSSTSIPLPQLIARINAERGGFRNISEDSLRLEIAEAEAGGNEEENESSSEDGEAEEEPDRLKELLTARDEILDAPVQASTSISPSLRELAGMGTLGADKTVASRYTKEQNQENKKIAKGWKASNLSKTVDSILASATRLEKEIDAETKYWEQVLAVSESGWAVCRLPQEKHTLGVRFGFSEASPTFRNRSLGALRRNPDGSIYLDQGIASPEPQSIRVLIETNGVTTGETILPKAVPHDAPIQDLILQARNTIFASELWQEMTREVRTLASHGLQSDSKTNTIRFPISPTKRILIELQAVPTDPFRPVLGPRPDSYLANGIYLTLHLLLSLSHRQQYRIRTRPPPPISSQPRPNNPFPILRSLVTRLAHETVVSSLHSLLTPLCKTLTSASLPTPPTYTISPGTSPPLLHLSTPERILTALTNQLEFFTTITFPFPLSSPPHSSIPSSFSHTTPLTPLPSSLQIRTVTTTLNYSRPIYYLRITPETSPLLQICPPPNTVPEWDYVKNYILWAVSCWLAHIFSSSSKTSEDKEEPWKPTTQPNILRKTFSGESPNEGGVKQICFDVSSIPILGPEAPTKIGEKEKEKIKISVRWEWTTGMEQEWKDKKDLKSGEGVYDWYYGGGGDGIAELQGGELEKMVRKMGDVVEEAGRGRSRS
Length674
PositionHead
OrganismBotryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytis cinerea)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Botrytis.
Aromaticity0.06
Grand average of hydropathy-0.466
Instability index61.81
Isoelectric point6.15
Molecular weight74614.53
Publications
PubMed=21876677

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27988
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.96|      13|      77|      15|      28|       1
---------------------------------------------------------------------------
   15-   28 (21.10/15.16)	APNTSSTSIPlPQL
   92-  104 (23.86/12.51)	APVQASTSIS.PSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.22|      19|      79|     413|     432|       2
---------------------------------------------------------------------------
  346-  362 (20.53/ 6.16)	..LLSLSH...RQQY..RIRTRPP
  464-  485 (22.46/ 9.89)	PSSFSHTTpltPLPS..SLQIRTV
  486-  505 (23.23/ 8.01)	TTTLNYS....RPIYylRITPETS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.91|      60|     149|     113|     172|       4
---------------------------------------------------------------------------
  113-  172 (97.52/71.39)	LGADKTV.ASRYTKEQNQENKKIA.KGWKASNLSKTVDSILASATRLEKEIDA.ETKYWEQVL
  265-  327 (88.39/63.90)	LQARNTIfASELWQEMTREVRTLAsHGLQSDSKTNTIRFPISPTKRILIELQAvPTDPFRPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.04|      34|      38|     374|     411|       5
---------------------------------------------------------------------------
  365-  400 (53.43/40.21)	ISSQPRP..................nnPFPILRSLVTRLAHETVVSSLHSLLTP
  405-  458 (46.61/24.13)	LTSASLPtpptytispgtsppllhlstPERILTALTNQLEFFTTITFPFPLSSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.85|      22|     473|      65|      90|       8
---------------------------------------------------------------------------
   65-   90 (28.21/23.79)	SSSEDGEAEEEPdrLKEllTARDEIL
  541-  562 (41.64/21.69)	SSSKTSEDKEEP..WKP..TTQPNIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27988 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISEDSLRLEIAEAEAGGNEEENESSSEDGEAEEEPDRLKELLTARD
2) MSTLPSNHPLSLRPAPNTSSTSIPLPQLIA
42
1
87
30










Molecular Recognition Features






MoRF SequenceStartStop




1) GVYDWYYGGG
632
641