<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27985

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDLGDQPTNVLCCDNFASITYEYFEPQWPSPSSITKKHLQDVETAWRNHGNLVYYDAKREGIWVFQPSPNSPNKALDEGDDSLSQANLPSVRGVELVKKDKGTYEPSYLAKSKSMLAASLNTPNSASSPSPLENALRNAQNVNARAMQVNSAQNLHDPAGSSPGVKSVASIGDTFAFLKEVQEHFISSVQGSIMYKLCNDHGLIPLNSRTLLLPSESPSRSMAYYQSPKVSDDTVTLVDLDISLTSLGALMIKACSYVTPGLQSINHTSPEKLQRILSQGTDLWLAPGGNPAKFYSFYDDEQLPGIQPISDLQKYPEDHSWRFHGTTIKSWQSRCLDWLSTKGFDSSLIDEGGWMFVQVLNTNYGSSNPEYADIPSSDEGAIVPWPTLLCFRAIKTSTTDLQPSSANSFGLVDPLTFVEEWSMNAEERASIMSNRQQERNVLKAAKEQADQEAQNIRANNHSTALLEKGSNAGAMYPTPPDAIHHPGGPTPSFDGAVTTPGNPAHLFSHDLETTNPNTSIMNTADTDNWVTSEQKHRSNSNMNFEENENDNDNLFGDMGGDLFGDTDITDADFNFFDQPDDIEMEHQSGSAVEPNLPPAPQHKIVEKSSVSSKPLVPQPTSKDTIMKDSQPTENNKRQPTFDQRFATSEMDMDVEMSNNNDNLIASAQPPLPPRIVAPFDKEIVFGQLARRKRKRKSKSQSSSGSSEFDEVKFEYSLTEVDEKYGYNGRFRYSDDDLKPQLVEPHDPTNPESFGRRKSENKALESDVLSRILNNDNAQYEFELDNEAELDVASESNSISDASESDDALPTGVSAIVKLGMKGKRYFDEASISSYNAFTGEYEPSAGTPQSIIEPHIPIFESDPADWSLTPYFTSPEPDIQPSGLSDLDLIETAQIIADQAAPGTLRVNDQICQNPDAHDQATFATRRLMTDVLQATKVCLKDVKSCTLRSYLTIPGIPAVNAALRLPPQGRPMPNPRAAQQTDPSKSSNPFPIQPPQLEVRRGDSKLAVLPPAIHFWDNLGLAPYTGNKDVNAVCIYPNIVGINENADIFLDQMRGAYESFRFGGHDRIMFPESPSGLLNYPCDVNTNKAAYLSSLKDVLTRLGKNLSSMTTEEKNVVVYFVYPLNNSSLLVNICTAFKHLFKVYRKSLSEKKLKIYNELVLQLVPLDFMAAPNSLIVPSPAEYSRLAMEVYDRCVDFASSSTTAAILLEKPLPRNIDFKLNINPSPALLQENSCLHIAYAQSIDERWITAAWSDNRGTKQMTASYCLGRKNEPFTLLFTDVANEIWETTLDLISSKKVHWRIIIAKTAVMEQSEIDFWTGLASTESNGSISLTLVTVQTDPSLRILPPQIRIPPPSMTTSQPTTTPVSTPQASQSSVFSPGNASTPTANAPTPSEAQSTSTPAVPPEPDDQSSRLLDITDQTWGAILSHRLNNSNSLLEFNPALISGYLVKNSGTSTDDPPIVLEVNIIYAEVVGNPRTFHDTLLREILGYYRGLATLARVRGVVHPVRDGRPWHIAAAEKAVKALYMLL
Length1531
PositionKinase
OrganismBotryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytis cinerea)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Botrytis.
Aromaticity0.08
Grand average of hydropathy-0.464
Instability index50.04
Isoelectric point4.92
Molecular weight168889.76
Publications
PubMed=21876677

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27985
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.89|      17|      19|     840|     858|       1
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   22-   39 (29.26/13.16)	EYfEPQWPSPSSITKKHL
  840-  856 (32.63/16.37)	EY.EPSAGTPQSIIEPHI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     264.17|      87|     531|      66|     218|       2
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   82-  171 (128.93/147.48)	SLSQANLPSVRG..VELVKKDKG.TYEPSYLAKSKSMLAASLNTPNSaSSPSPLENALRNAQNVnARAMQVNSAQ..NLHDPAgSSPGVKSVASI
  221-  312 (135.24/51.83)	SMAYYQSPKVSDdtVTLVDLDISlTSLGALMIKACSYVTPGLQSINH.TSPEKLQRILSQGTDL.WLAPGGNPAKfySFYDDE.QLPGIQPISDL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.10|      15|      18|     962|     976|       3
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  962-  976 (29.44/16.96)	AALRLPPQGRPMPNP
  978-  992 (27.66/15.37)	AAQQTDPSKSSNPFP
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.89|      14|      18|     585|     600|       5
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  585-  600 (19.13/15.33)	EHQSGSAvEPnLPPAP
  606-  619 (25.76/11.33)	EKSSVSS.KP.LVPQP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.49|      18|     531|     869|     887|       6
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  869-  887 (31.55/19.43)	TPYfTSPEPDIQPSGLSDL
 1402- 1419 (34.95/17.04)	TPA.VPPEPDDQSSRLLDI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.37|      43|     144|     478|     525|       7
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  478-  525 (75.21/54.44)	TPPDAIHHPGGPT......PSFDGAVTTpgnpaHLFSHDLETTNPNTSIMNTAD
  620-  668 (69.16/38.80)	TSKDTIMKDSQPTennkrqPTFDQRFAT.....SEMDMDVEMSNNNDNLIASAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.58|      38|      41|    1043|    1082|       8
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 1037- 1080 (58.54/55.55)	YPnivgINENADIFLDQMRGAYEsfRFGGHDRIMFPESPSGLLN
 1081- 1120 (57.04/45.56)	YP..cdVNTNKAAYLSSLKDVLT..RLGKNLSSMTTEEKNVVVY
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.94|      34|     531|     175|     218|       9
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  175-  218 (42.56/48.27)	FAF.LKEVQEHFisSVQGSIMYklcNDHGLIPlnsrTLLLPSEsP
  713-  747 (60.38/34.32)	FEYsLTEVDEKY..GYNGRFRY...SDDDLKP....QLVEPHD.P
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.86|      18|     531|     766|     799|      10
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  767-  787 (27.69/39.51)	VLSRILNNDNAQYEFeldNEA
 1427- 1444 (33.18/ 7.84)	ILSHRLNNSNSLLEF...NPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.86|      16|      18|     898|     913|      11
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  898-  913 (29.37/19.08)	DQAAPGTLRVNDQICQ
  919-  934 (27.49/17.39)	DQATFATRRLMTDVLQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.48|      75|     897|     335|     418|      13
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  335-  418 (115.30/93.71)	CLDWLSTKGFDSSLIdEGGW........................MFVQVLNTNYGSSnpeyADIPSSDEgaiVPWPTLLCFRAI.KTSTTDLQP..SSANSFGLVDpLTFV
 1235- 1336 (108.19/63.72)	CLHIAYAQSIDERWI.TAAWsdnrgtkqmtasyclgrknepftlLFTDVANEIWETT....LDLISSKK...VHWRIIIAKTAVmEQSEIDFWTglASTESNGSIS.LTLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.96|       9|      37|    1354|    1364|      14
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 1354- 1364 (14.54/13.77)	PPPSmtTSQPT
 1392- 1400 (17.42/ 8.10)	PTPS..EAQST
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27985 with Med13 domain of Kingdom Fungi
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