<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27983

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMQGRAILRGSACDFAPTAPLQSAEYSNPVSTAKIESINHRKVEEGAAVGVPQGGGALVGEQGRDTMPGVIMDSASRNGSHTNHDRDRQFNGPNGEAKASEKGRDKSQARSEPQQSMTPISPAVRNGMNGNSTDGPAHQQNSGEEPIPKDILDRIHDLPPEVEHITSNFLPLTELLNRLAQATHNDLRQEIMKLANMPIPQSAMNTNPPHITKEDDTSNDNVNKKVSLLNFAQTQHSRWVKQLVLLNWSRNAEEVSKIIDLNIHLCQKRGLYQYILHHMSEVKRKLCDVDSPRPDLKTAVEVLSTGKANWMPDLGYIAPPPMTPKEILKSLEKLNTLLSIRLNLHEYDKIPLQFKNYTIKSGRVTFKVAGEFEIDLTVADENQELQFWFIDFRFLFSPSLSELPPRHQYHIENKVNAALEKDGLSGCYNYLHEMVLTHKISEFRRQAVELSRSTWIDGVKVEPLHRALCIQYWLDRYKKNGPRSWIILGVHSGRRKDGYHDPKSASRLSIRWFRDSKEVKDVDIPFDTVNISAEQLLKTVIAMHVNHILGSTHSKLAAESIFANREASLSLHTSKTEPKESVLGVQLTEKQHVSITIEPVTGIFIFSPASRVITSSQNKLNSLDRDPAMDAHFNIENLRCLAISEELTILGTSVGWRRADNPGISREDLKRKIPKDTKQISWFRRPGWQEDWLVAVTLGMSGENWWLFQISKQSTGVKVLASIHIPIKAASPTTSYVFMSTLHIFAGGLISQYTNLKALHDRRIRHTVRQSALLSPVKLPSIWIHIPGLFQARAKPTAHKTWATDFLKLDFQGLEPISNPLSVLSQSPIDDSQAIVPKPEQKTILVTVARMAVPIPALAVLNEKIDQDIAFQSKTGEIAFRLRSQVGESIIPALTERLFQIERLISCTAVLRKHENVIKCDRISLQEIAFSYGMPPVAQTGLVTSADKTTPLSYKAVVSLGLVEGKMKLTLEMGNPHIRVLDSLDKVLNIAKSGFDAVATLLPQTLYSLRAFETIENAWASLYDKGEVFVFVRAFEWFRLRYVFKPSTPNTPPRTVSFEIKMCHRKQKPWWLVRRTEKIDKSIRGDAVPDDEIDLRLKSVWDSRGDDDWKGMRTSAVGRNRGIETCLEKIDAVMRDLSPEDLAVQPSQQSQTNTQVQAVGPQGQQPSQSQQQRQLQLSTPTNSQNHPQSQGSSQGQQRMPTPNMNMNPNMNQNMNQNMNQNMLKRKSSGQAINPRAVKREVVEID
Length1244
PositionTail
OrganismBotryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytis cinerea)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Botrytis.
Aromaticity0.06
Grand average of hydropathy-0.463
Instability index51.48
Isoelectric point9.12
Molecular weight139963.06
Publications
PubMed=21876677

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27983
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.87|      22|      23|    1144|    1166|       1
---------------------------------------------------------------------------
 1144- 1166 (36.65/22.66)	QPSQQSQTNTQVQAvGPQGQQPS
 1171- 1192 (40.23/21.05)	QRQLQLSTPTNSQN.HPQSQGSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.90|      20|      28|    1067|    1087|       2
---------------------------------------------------------------------------
 1067- 1087 (33.04/24.47)	KPWWlVRRTEKIDKSIRGDAV
 1097- 1116 (37.87/23.58)	KSVW.DSRGDDDWKGMRTSAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     379.95|     109|     169|     449|     559|       3
---------------------------------------------------------------------------
  449-  500 (60.63/40.43)	.................................................................................L.SRSTWIDG..VKVEPLHRALCIQYWLDRYKKngPRSWI.ILGVHSG.RRKD....GYHD
  501-  559 (70.57/40.56)	PKSASRLSIRWFR.DSKE.VKDVDIPF.DTVNISAEQLLKTVIAMHVN..HILGSTHSKLAAES..............................................................................
  568-  667 (104.58/64.80)	......LSLHTSKtEPKEsVLGVQLTEkQHVSITIEPVTGIFIFSPAS..RVITSSQNKL..NS.................L.DRDPAMD.ahFNIENL.RCLAISEEL..T..........ILGTSVGwRRADnpgiSRED
  673-  798 (144.17/92.38)	PKDTKQIS..WFR.RPGW.QEDWLVAV..TLGMSGENWWLFQISKQSTgvKVLASIHIPIKAASpttsyvfmstlhifaggLiSQYTNLKA..LHDRRIRHTVRQSALLSPVKL..PSIWIhIPGLFQA.RAKP....TAH.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.08|      25|      30|     155|     184|       4
---------------------------------------------------------------------------
  158-  183 (41.29/39.82)	PPEV..EHITS..NFLPLTELLNrLAQATH
  207-  235 (36.80/15.33)	PPHItkEDDTSndNVNKKVSLLN.FAQTQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.53|      31|      35|     822|     856|       5
---------------------------------------------------------------------------
  822-  856 (39.15/51.18)	VLSQSpIDdsQAIVPKPEQKTILVTVaRMAVP...IPA
  859-  892 (47.38/38.01)	VLNEK.ID..QDIAFQSKTGEIAFRL.RSQVGesiIPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.16|      16|      23|     293|     308|       6
---------------------------------------------------------------------------
  293-  308 (26.81/15.56)	PDLKTAVEVL.STGKAN
  318-  334 (25.34/14.31)	PPPMTPKEILkSLEKLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.27|      12|      23|      74|      85|       7
---------------------------------------------------------------------------
   74-   85 (22.71/13.38)	ASRNGSHTNHDR
   98-  109 (18.56/ 9.62)	ASEKGRDKSQAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.23|      18|     646|     387|     405|       8
---------------------------------------------------------------------------
  387-  405 (33.31/22.25)	WFiDFRFLFSPSLSELPPR
 1036- 1053 (38.92/21.93)	WF.RLRYVFKPSTPNTPPR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27983 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AILRGSACDFAPTAPLQSAEYSNPVSTAKIESINHRKVEEGAAVGVPQGGGALVGEQGRDTMPGVIMDSASRNGSHTNHDRDRQFNGPNGEAKASEKGRDKSQARSEPQQSMTPISPAVRNGMNGNSTDGPAHQQNSGEEPIPKDILDRIHDLPP
2) DLRQEIMKLANMPIPQSAMNTNPPHITKEDDTSND
3) MRDLSPEDLAVQPSQQSQTNTQVQAVGPQGQQPSQSQQQRQLQLSTPTNSQNHPQSQGSSQGQQRMPTPNMNMNPNMNQNMNQNMNQNMLKRKSSGQAINPRAVKREVVEID
5
185
1133
159
219
1244










Molecular Recognition Features






MoRF SequenceStartStop




1) MLKRKS
1221
1226