<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27982

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEDVDNMEVDMDDLFGDGTGLSLPSRPPPSKELHQRVDELRGSGCCQGIAWSKWGSIASITPNGSGLELRNLRCHPGDGTWGLSEATVIPQLTSNLDGGPLKHLSWSPTGSELAVIDSAGRVTLLQIFSSLNKPMMCRPCGPDPADDLHAVVGCFWLNLGPFQNRTASRVQQGPAIKEASGFRYDASTAPNLGPTHPIPTKSAFVYVTSNGSLRLLWLQSNGKWLESHTELESIISSDDLITHAAICAERGPSLLIALATSSKQLRIFRAVIHWGLPQTQEKVTSMTIALNATLQTKPLTVTSWLHDVPGDTLNASHLESSMVQLSHLKFLSPTVDSKNHMTPPIVMAVRSYLPGSTSHYNQEVYSTVDRWEFRERPQQPVHSAFENLSSRKSTDGSQATKPVVTAQLKKLESFTVNKIIVAVQTIYLGRVINFAYSDSSVDYRDRITMNETFNDDDLDRVVHLSQIGFSYTEDEPCLQVALSPSTCSLVQIRNDGKVKWKQLDYHLGDIGSTMEHPRYAAMIAALSISCSTSVIMSINYDDIIATAHNLAETKDNLAYDWLNELAKILKIIADYSEEAHYDVLIRNTMIQLCLSIQNSLGFTGEFNARKFAGKFSWLVLQLRNTVVLVTMAANMKVPGPTHDTKSTPLDDPEVITALAGSVRWVLDLMAWITDTLLELPSTLPEDLSVTNPTKLSLPELLAYLHATNNVTLHLLLSSPTRGFLTAICRRLQHLDYVARKAIATNTNHPNQAGQGQQSISPTLRAAYVQIANLTSNCIVRIKTFEALLSSLTSSIKSAYANHKPPLAGNTNNSTGPSRNNLEIKMLLGGEIPTAFKAVIVDLFRGVQDNEPKTQNDLGANAAAPGYLSSVRLEIDPANLWFADFTMLEVDEDEESVAKRKGSGVTMDCFRKTWLINPPSTSSKSSLNKAIENGNSVDKDNSLPTIQGMPTPQGAGGSGNTNGNANGNANGGHGSGNTTKRWRRCARCASVMEDVLSQRPALQWLVMQQRRCFCGGYWDTLVNGEMVA
Length1027
PositionTail
OrganismBotryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytis cinerea)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Sclerotiniaceae> Botrytis.
Aromaticity0.07
Grand average of hydropathy-0.227
Instability index35.23
Isoelectric point6.13
Molecular weight112370.13
Publications
PubMed=21876677

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364149
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27982
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     141.30|      24|      26|      39|      62|       1
---------------------------------------------------------------------------
   13-   28 (28.99/13.66)	DLFGDG..TGL.......S.LPSRPP
   39-   62 (48.78/28.19)	ELRGSGCCQGIAWSKWG.S.IASITP
   68-   90 (35.48/18.43)	ELRNLRCHPGD..GTWGlS.EATVIP
   95-  116 (28.05/12.97)	NLDG.GPLKHLSWSPTG.SeLAVI..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     236.14|      76|     445|     189|     268|       2
---------------------------------------------------------------------------
  189-  268 (123.52/84.45)	APNL...GPTH...PIPTKSAFVYVTSNGSLRllWLQSNGKWL.ESHTELESIISSDDLITHAAICAErgPSLLIAL.ATSSKQLRIF
  632-  715 (112.62/66.37)	AANMkvpGPTHdtkSTPLDDPEVITALAGSVR..WVLDLMAWItDTLLELPSTLPEDLSVTNPTKLSL..PELLAYLhATNNVTLHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.12|      16|      16|     427|     442|       3
---------------------------------------------------------------------------
  427-  442 (27.94/20.99)	YLGRV.INFAYSDSSVD
  443-  459 (25.18/18.12)	YRDRItMNETFNDDDLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.54|      13|      20|     550|     562|       8
---------------------------------------------------------------------------
  550-  562 (23.01/14.52)	LAETKDNLAYDWL
  572-  584 (22.53/14.07)	IADYSEEAHYDVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27982 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MEDVDNMEVDMDDLFGDGTGLSLPSRPPPSKELHQRV
2) TSSKSSLNKAIENGNSVDKDNSLPTIQGMPTPQGAGGSGNTNGNANGNANGGHGSGN
1
920
37
976










Molecular Recognition Features






MoRF SequenceStartStop




NANANA