<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27974

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLMLDNPMETTTHDGDQVMNHDAISAGDIPMNGPMQVDGLDVDDLFGDGVNLTLPNVRAPSRQLAQRVDEMRTRGCAQGIAWSKSGTIASISPDGRSVQVRYLRADPKTGSWGLSEPTTVDAITASPSTPIVHLAWAATSSNELAVIDAAGRVAILAFSVSLNRPFLTRKWDADHVDDLHAIAGCFWLPLASQHKNYHVFHGPAVKDATAYRYESSFIHAFGPWHPNPAKSALLCVTTSGMLRLFWSQSNNKLEETTLELDSFSSSDDLITHASLHSDKNHMYVALATASRQLRLVRPLNPTMTAKHLAISSWMPNGQSGNPIDASMTQISHIELLPSQLDNTGHNWVPMSVLVVRSYLPTTNSPFQEMQSVIDRWEVGHEPSPALHPAFEQMGSRRNSSAGGNDKDPNRLKRLDPVFINKVIVGMQTIHFGKAVCIAFSDGSVEYRDRFTMQETYNELSLDRVMTLNQVGFTFSEGTPCLQVAFSPTNCSVAQIQDDGQVKWNGLHYPLGDIGNSNQDVRCSHRGSHSSGFCCDILPAFTRDWVNELVRMLKVPVDYSEEAHHEALVRNSSLQLCFSILNHLGFNGEFNPRSSSGKFAFLSLNIRNVVILITIASNTPTNMREKLNPLDEHEVIDALCGCAQWSVDLLAYLADSLFALLDDPKFTELLQPRNYSEISNYLRSRSDPSLQLLLCSATRGFLSAVCRRLTHLDQISHRAIEFYDRRAAMQNATDPSGQSKVATIALNKSYQRMQHIISNSHIKVQDFDHLLTTLTSDIRSTYQTAFAGLAAQAQQKNESNGTANTQQGQKQIDAQIRGAQIISELNLLLAAQPPAPFLTVLKKLFGQDLRAFRAQTDPSKLFFADLGLLEVDDAPRVLGARRAAARYVDVFRRVEMTNRAGPREETPEEQLQQRGGRGGPLQWRRCVRCAAVMEDVFGSRPGFTFVLTQQRKCSCGGYWALLPKASIA
Length968
PositionTail
OrganismVerticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137) (Verticillium wilt)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.08
Grand average of hydropathy-0.274
Instability index40.80
Isoelectric point6.46
Molecular weight107199.08
Publications
PubMed=21829347

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364149
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27974
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     377.72|     120|     132|      82|     212|       1
---------------------------------------------------------------------------
   24-   94 (62.32/43.75)	................................................................AISAGDIPMNGPM...QVDGLDVDDLFGDGVNLTLPnvrAPSRQLAQRVdeMRTRGCAQG.iawsKSGTIASISP
   95-  224 (197.05/159.74)	DGRSVQVRYLRADPKTGSWGLS....EPTTVDAITASPSTPIVHLAWAATSSNELAVIdaagrVAILAFSVSLNRPFLTRKWDADHVDDLHAIAGCFWLP...LASQHKNYHV..FHGPAVKDAtayryESSFIHAFGP
  229-  316 (118.35/80.32)	PAKSALLCVTTSGMLRLFWSQSnnklEETTLELDSFSSSDDLITHASLHSDKNHMYVA.....LATASRQLRLVRP.LNPTMTAKHL....AISS..WMP.......................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     352.12|     107|     117|     461|     577|       2
---------------------------------------------------------------------------
  468-  577 (183.23/166.54)	LNQVGFT..FSEGTPCLQVAFSPTNCS....VAQIQDDGQVKWNGLHYPLGDIGNSNQDVRCSHRGSHSSGFCCDILPAFTRDwvNELVRMLKvPVDYSEEAHHEALVRNSSLQL..C
  581-  695 (168.89/125.31)	LNHLGFNgeFNPRSSSGKFAFLSLNIRnvviLITIASNTPTNMREKLNPLDEHEVIDALCGCAQWSVDLLAYLADSLFALLDD..PKFTELLQ.PRNYSEISNYLRSRSDPSLQLllC
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.58|      15|      15|     844|     858|       3
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  844-  858 (26.95/17.40)	LFGQDLRAFRAQTDP
  861-  875 (25.62/16.17)	LFFADLGLLEVDDAP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.82|      40|     325|     388|     430|       4
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  388-  430 (62.83/48.12)	HPAFEqMGSRRnsSAGGNDKDPNRLKRLDPVFINKVIVGMQTI
  717-  756 (70.99/43.55)	HRAIE.FYDRR..AAMQNATDPSGQSKVATIALNKSYQRMQHI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27974 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPLMLDNPMETTTHDGDQVMNHDAISAGDIPMNGPMQVD
1
39










Molecular Recognition Features






MoRF SequenceStartStop




NANANA