<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27967

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSQYGTNIFLIKGISSIAYQLYEPAPEQAQAFASIAPTIEKSLRDAGRVAHFDTSRRALWHFYIPRHDATQPTAHTEEGGALDHSLDVAGFNLVLTDEGSFEPGHLFKSRPIGQRQTAANTPTHPAFNGSVPDATLRNASSFDNTNTATPSSSDPEGKPTPITSSDGKIYITVKIAYEQFISAMLSTVSSPICRSLAAIPLNHCTILLNSKIIRQGESKNASGTETAVLGIFRIYLTTNGTLVISFSLVLSEDTRLWRPRPEPDAKSSQWREICTGMLKGWGLSGHTLQNCTWVALQLSPRKPVDLRAEGRGTPVRNSSPPMIFSWPSILCFRKRSVDPQANQSERTDIALASKEAADSLTEVKTWFQSGTEREESIVQRRKAREAVASAKEAQAQAPAAPQPTDQFPMDPRRAANAAAASAMYPTPPDAVQNPLGIFTAPAADAVTSSPGPPSSVAAPVDGDAPMVNAVVMADTEPDSWEQTDTKRDRVDSTFEGDGNLFGDMGPDMFGDTDITDADFSFFDEDDDNNPLDLNMSAPDTTMTSLPTTTPEPVLSQADILPPTIDEISEETKPKMEAPIFTKPELRHARSTLNDETRGRPTSEISKALSNKREPSPFDPATVFKKVRASLGRLNNQSLGSPSTVTARKGSVFDSIEFDPVLPLASKKYEQGGRFACRWTPTQSDTSLSLKKPPTTDYLRRHSKLHRKPFRTDNTNARIRSITDGLENSSLQASPDKIEELSSDADDMSLESDVDESPDLMEEPTSPFKASTKRLNLEDDMVSHVTSLRDVESVVEDSDPSLPLELPRIARFEVPEVAVAKYFDDPEPLLSQLSLQDDDIITVAQILTEQAISGNLCLRDAQSATFNSPVAPETRRQLASLSRTLSLVLQQAIPAALGDSTQCRFRELIEASDVPLLGPPSRAQPRPVPPRDPNAEPPKPNYLFQIPPPHLEIRRLDSKLSVLPSTISFWETLGLGPSQGVKNITAACVFPNLNGLSDFATTFLGRIRNTYEFLKLGGFDIVNGESGHTTGGLVPWEEERLTGTPTVDGAMHGSSLADRMDSLNQSLLSLEAREKNFVVFIVYIPSHPESIVEACTAFQQLFELHKKALADKRLAPSNELVLQLLPVDFLTAVSGMPTALPIDLIKLALETYDRCTIFGGPMPAPAILLEHTLPRNIDFRLNNTGSSSLMHENTCIHIAYAQSVDERWITAAWTDNRGSQQMTASYNLGRKGKSLSSSLNEVTHEIWETTHDLISRWKVHWRIIITKCGCMDQSEIDFWVGLAQTEQQASVSLTLITVDTSPSLQLVPPAVKVPPTASTSFYTTPVSTPQPSTVSPDQIGTPSTPMKDGSQANASTPTGTPGGADVAEPAEGDAILVDVTDQTWGAVLSHRLGNSTAPGELSTSLISGYLVKRGGTKVEDPPVVMEVNIVYTDGNPRALEALLREMLNYFRGLGTLARARGMVDRETDVRPWHIAAAEKGVRALYLLM
Length1489
PositionKinase
OrganismVerticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137) (Verticillium wilt)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.06
Grand average of hydropathy-0.354
Instability index50.48
Isoelectric point5.07
Molecular weight162284.54
Publications
PubMed=21829347

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27967
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.52|      22|      22|     427|     448|       1
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  412-  437 (32.92/14.13)	DPRRAANAAAAsamyPTPPDAVQNPL
  438-  462 (33.60/14.58)	GIFTAPAADAV.tssPGPPSSVAAPV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.74|      17|      22|     727|     744|       2
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  727-  744 (24.55/19.46)	LEnSSLQASPDKIEELSS
  751-  767 (31.19/19.74)	LE.SDVDESPDLMEEPTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.16|      15|      24|     800|     822|       3
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  801-  818 (22.91/16.39)	PSLPLELPRIarfEVPEV
 1303- 1317 (28.26/ 9.70)	PSLQLVPPAV...KVPPT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     242.03|      47|     364|     548|     594|       4
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  548-  594 (78.48/44.38)	PTTTPEPVLSQADILPPTIDEISEETKPKMEAPIFTKP....ELRHARS.TL
  827-  867 (49.87/25.03)	....PEPLLSQ...LSLQDDDIITVAQILTEQAISGNL....CLRDAQSaTF
  868-  908 (49.13/24.53)	NSPVAPETRRQLASLSRTLSLVLQQAIPAALGD.STQC....RFRE......
  916-  961 (64.55/34.96)	PLLGP.PSRAQPRPVPPR.DPNAEPPKPNY...LFQIPpphlEIRRLDS.KL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.98|      22|      26|     476|     499|       5
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  464-  497 (26.71/18.18)	GDapmvnavvmaDTEPDSWEQTDTkRDRvD.STFE
  498-  525 (34.26/15.37)	GD.....gnlfgDMGPDMFGDTDI.TDA.DfSFFD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.22|      24|      47|    1187|    1214|       6
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 1187- 1214 (36.22/34.66)	SSSLmheNTCIHIAYAQSVD..ERWiTAAW
 1237- 1262 (43.00/26.32)	SSSL...NEVTHEIWETTHDliSRW.KVHW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.16|      14|     363|      27|      40|       7
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   27-   40 (26.42/13.55)	APE.QAQAFASIAPT
  392-  406 (22.73/10.63)	AKEaQAQAPAAPQPT
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.81|      20|    1216|     143|     169|       8
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  148-  167 (34.99/14.96)	NTATPSSSDPEGKPTPITSS
  612-  631 (31.82/ 7.20)	NKREPSPFDPATVFKKVRAS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.20|      38|    1216|     109|     147|       9
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  109-  147 (62.88/31.93)	FKSRPIGQRQTAANTPTHPAfNGSVP..DATLRNASSFDNT
 1322- 1361 (64.32/28.94)	FYTTPVSTPQPSTVSPDQIG.TPSTPmkDGSQANASTPTGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.81|      14|      24|    1012|    1025|      10
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 1012- 1025 (25.38/14.20)	YEFLKLGGFDIVNG
 1037- 1050 (26.42/15.07)	WEEERLTGTPTVDG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.31|      15|      26|     963|     977|      12
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  963-  977 (27.94/13.70)	VLPST..ISFWETLGLG
  990- 1006 (22.37/ 9.61)	VFPNLngLSDFATTFLG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.62|      21|     311|     329|     357|      13
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  303-  323 (36.77/24.15)	RKPVDLRA.EGRGTPVRNSSPP
  336-  357 (28.86/12.26)	KRSVDPQAnQSERTDIALASKE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27967 with Med13 domain of Kingdom Fungi
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