<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27962

Description Uncharacterized protein
SequenceMWLFGPPHQPNAEPPGELWKPSCPPLVLAPDLFLAQGALQRGELRTARPEPPSPFDLSFPRRAYHGSRSLPCLLRAPALATGPSQPASQPGGQLVRRWIGPSKNPHRYRYVATTCLITPPTQPTPSTTIAQHVVAAIPVLAMTSRTPMGVQPRPPQQRTLSSSGLTVQRPPHQRTLSAQYLPPSPVRKEPSNLIDLTGDSNDVAVAQNRYGTVPRRGGSRLKLELSNDSTLFQPATESPQNLTPSRLVPKNDASSLADTNSPASTRAGPLDNDNPPMPMPKRRPRFALPTPPKDTKPAVIATKKDGRPKPYSAEIPPDAPRYAPLNRPKADATKVGYGASATAKESHDMGNADFFSWTGNHPEDRLSDAVIKNGYFDKAPVTQAETTSAKPAIFPALKHKNGLNLLSSIFVGVLNQRKHNGQVVAPSAFKPPPRVTLTDTKREVWMRDLANPAISLRRLSRTIPHGIRGKGLLDHCLNKNVPTERAVWLVRCVGANDLRTVKRKGVNGTVVMGGEAKWLKDWTLYVEQFVESVASAFGEVDWKARVQYAIRLATHLYAEHLVDRDHYMDWLVGGLENSTQSKLPMWILISQIYWKDLLRLRRHGRRLANALLSHLTTIQSDPDRDILAQLSTKLTSLLLPLLSSYPDNFLSPTTWLRCRETLLASIPIDNDAVLSAYKALNSRNEVLIASSGKSQPANRQILIKQLDTTFQTLYTNELASSCWNVSEDKRMIVRTVLEWSTSFYRPGQARIYVAASLLRAWASTGVDITTAILESIGAAPPQGTTPKRLFYQLISELVRTGQFNVREYVVWLMGRGGMTSSLDTEPDAPCSTRLLIDLPLSALSSSFIATRANLLRRAAFDVAEEARDIDAAWNFIRHALGLSSDAEISPAQRRPMPLAKICRAVSNSSRALQTEVGARLLQIFQTDDYESSSDVHLSPTAFNHARSILEAAKDFTTMAEMIKLTSRFPDADILASCADTVNVHLPTFAAMNVARNLCDLLLERMKIVNDEQGVRVRPLLVALGALTARLPGLANTSAHLRKELQQIDQSTAIDACSPVSDNMAARLQDAEGELNDEIERLLTGGTSLDRPTMDRLFHTVVTRIEGSWVKDSEKQHAYSALLARLRIFDTQHFDVRMTDWVHHVSIMKTRPTLFDIYPFLISLGCLGLSTIMTTTTIDPSKVVGGQVGCTSTYMQEVLQLVVSPLPPKNALSQEEAYRFYVQQRVAPQQYHRELAVLIRNSLIEFSKLQNSEVSTSAPLARQDLRDDVLDLLRLLVLNDSPTTVQILGTKLADSPLSDVLASITTRLLAPTRDPNDPMTFETVLELANDFTLPFCQLKLSIGLAASKAGGSSGDEQPASHVDMLSKALDQAVETKNMMWTSVLPYLSEEITDHLKRQAQTRLFSLVPSLKTMSTAGDSSEDMIRLSESLLSVVEAIIRGRPALKATQLNMSMVDKLTELWELLAATELIGTDLRMAIIEHWLPLLLKFITLHTTANEPVLSPTQPASMKPPTTAAANDVRARMLVVLSGIMLELDNISCEEARSGRQLRQTTFDLALFLVDHLPEESRLQCVRAILIGGSLQAPVTSDAGIRYLFSYAAPWMEQFMLAHRQTPTPPSNGPPRPKIPISVQGSARLTPYIFRRWELLSEPSPIVGENDTALSLSLFEAIKIQ
Length1671
PositionKinase
OrganismVerticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137) (Verticillium wilt)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Plectosphaerellaceae> Verticillium.
Aromaticity0.06
Grand average of hydropathy-0.214
Instability index48.49
Isoelectric point8.92
Molecular weight184541.51
Publications
PubMed=21829347

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27962
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.95|      50|     105|    1422|    1474|       1
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 1422- 1474 (73.78/44.92)	MIRLSEslLSVVEAiIRGRPALKAT.QLNMSMVDKLTELWELLAATE.LIGTDLR
 1531- 1582 (77.17/38.73)	MLELDN..ISCEEA.RSGRQLRQTTfDLALFLVDHLPEESRLQCVRAiLIGGSLQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     286.37|      73|     202|     618|     696|       2
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  622-  696 (113.64/79.14)	PDRDILAQLSTKLtSLLLPLLSSYPDNFLSPTTWLRCrETLLASIPIDND.......AVL......SAYKALNSRNEVLIASSGKSQP
  969- 1037 (87.73/45.87)	PDADILASCADTV.NVHLPTFAA.....MNVARNL.C.DLLLERMKIVNDeqgvrvrPLL......VALGALTARLPGLANTS.....
 1295- 1357 (85.00/44.08)	PLSDVLASITTR...LLAP..TRDPNDPMTFETVLE..........LAND.......FTLpfcqlkLSIGLAASKAGG...SSGDEQP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.06|      13|      15|     148|     161|       3
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  148-  161 (23.12/16.40)	MGVQpRPPQQRTLS
  165-  177 (26.94/13.78)	LTVQ.RPPHQRTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     224.33|      46|     114|      81|     126|       4
---------------------------------------------------------------------------
    7-   31 (46.05/20.06)	..PHQPNAEPPGEL.......................W.....KP..........SC...PPLV.L...APD
   81-  126 (90.06/47.06)	TGPSQPASQPGGQLV....................RRWIGPSKNPHRY.RY.VATTCLITPPTQ.P...TPS
  182-  245 (37.84/15.02)	..PPSPVRKEPSNLIdltgdsndvavaqnrygtvpRR..GGSR..LKL.EL.SNDSTLFQPATEsPqnlTPS
  258-  297 (50.39/22.72)	DTNS.PASTRAGPLD....................ND.NPPMPMPKRRpRFaLPTPPKDTKP..........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.32|      26|     114|    1483|    1511|       7
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 1483- 1511 (42.42/37.38)	PLLLKFITLH.TTANEPVLSPTQPasmKPP
 1600- 1626 (49.90/34.56)	PWMEQFMLAHrQTPTPPSNGPPRP...KIP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.84|      35|     524|     367|     405|      10
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  331-  365 (60.51/32.90)	DAT.KVGY..GASATAKESHDMGNADFFSWTGNHPEDR
  368-  405 (49.33/39.73)	DAViKNGYfdKAPVTQAETTSAKPAIFPALKHKNGLNL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.22|      35|     524|     563|     601|      11
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  566-  578 (14.14/ 6.53)	.......................HYMDWLVG..GLENS
  579-  601 (25.34/14.32)	TQSKLpMWILISQIYWKDLLRLR...............
  785-  821 (58.74/32.96)	TPKRL.FYQLISELVRTGQFNVREYVVWLMGrgGMTSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.70|      27|     511|     426|     461|      13
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  426-  458 (44.40/41.01)	PSAFKPPPrvtltdTKREVWM.RDL.ANPAISLRR
  475-  503 (41.30/18.82)	HCLNKNVP......TERAVWLvRCVgANDLRTVKR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27962 with Med12 domain of Kingdom Fungi
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