<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27954

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMADSGPQGAASDKVEGLPDELRHITTDILPLSLLLTRLAEYSHAKLQEIITELAAKPLPQALANGNVNGTANGNGILHNVPIEDTSPESLDKKTMLLNFTKDLHSRWVKALVITEWSRNAEEVGKLIDIRTYLAEKLELYHKTFWNLVQVKREMLFARVPSPDLKTALEVLSNGAVHWMPDFGYLEPPPLTEEEKLHWTHEIEMHLHARLQLQEFDTMPDPFKKYRIGNGKVTFTVPGEFEVDLTIGHEDFSTQFWFLDFRPIYSPAPPELSQQLRQIIEARVNNALAADGLTGCYKYLHEFTLTAKITEFTRQALELSSTGRWADTLRVERLNRALGIQYWRNCQHSRVSQSWILLGVRSAEGPNEDPDAQASSSRLMLSWFRDGKEVKEVGIAFDVDTISTEDLLMAVIAKHIEHLLCPIYQTLVAKPRYAQRQGRLSLNIEKDPQRSRLSMQLVGELDATVSVSPWTGDFLLSPEYPSMLETQKKFRTLANPAEEGASVLEQLRWSYTVQHLRCLPSVADWVILRAAPAPFDEVKSMVYSLSPSIREAFHAVWVRNAKWGPQWFAALSMSLAGDHCWLVEISVEGQGSSGRRINTFRRLPSSPSDLLLPDMLFQKLAKYGPGIMAEIQSLRHGRQEHVAHAAQQQPANSSSSAASYQTNMLIIVARASELLPPSRIGSLDGTRPLWAQEYIPVTYKGLAPEPPPAIGSGDPLQRQAGPLRILVEARVAVTNRARFEFVKSRLDRDVRYDPRIGQFTLRFRPEANTSVIPMLRERIQALDRLFDFVEAVHRAGKHAVLESVTLHELVFTYGAHTAEAPPPPANSQDQGEQRSWKVRLNLSGARGVDVRLEQGNPHLRVIDYLRSIANSPKSKSLPAWLSLTLPLFRALERLQDSWDLPSANKQGECFILHKSLDWVALRFALAGPKSRRLQLDIKARERKGQLMWQVSRPSTDANANNENDEFTKVLAPKVWSVSGQGFQGLSTGAAANWDQGIENLLALISDTLLSMVGTPPQPQQQQAPPAGQAQEQLPAPPPGPAGRFPQQVQPSQQPLQHLQHLQQQQQHHRPPPPPPQQHVPQPGMHGQAQHQGQVQGPRAGMGQNNASVVVID
Length1111
PositionTail
OrganismThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Thermothielavioides> Thermothielavioides terrestris.
Aromaticity0.07
Grand average of hydropathy-0.393
Instability index52.44
Isoelectric point6.95
Molecular weight124403.08
Publications
PubMed=21964414

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27954
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     220.08|      48|     249|     815|     862|       1
---------------------------------------------------------------------------
  815-  862 (82.13/33.94)	HTAEAPPP...........PANSQDQGEQRSWKVRLNLSG.ARGVDVRLEQGNPHLRVID
  866-  907 (31.31/ 8.71)	SIANSPKSkslpawlsltlPLFRALERLQDSW....DLPS.AN......KQGE.......
 1039- 1068 (40.35/13.20)	...................PAGRFPQQVQPSQQPLQHLQ........HLQQQQQHHR...
 1069- 1111 (66.29/26.07)	...PPPPP...........P...QQHVPQPGMHGQAQHQGqVQGPRAGMGQNNASVVVID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.64|      14|      57|     560|     574|       2
---------------------------------------------------------------------------
  560-  574 (24.26/22.14)	AKWGPQWFAALSmSL
  620-  633 (26.38/17.58)	AKYGPGIMAEIQ.SL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.50|      34|     360|      24|      57|       3
---------------------------------------------------------------------------
   24-   57 (55.20/41.57)	ITTDILPLS...LLLTRLAEYSHAKLQEIITELAAKP
  394-  430 (53.30/39.86)	IAFDVDTIStedLLMAVIAKHIEHLLCPIYQTLVAKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.92|      29|     360|     648|     676|       5
---------------------------------------------------------------------------
  648-  676 (48.72/25.90)	QPANSSSSAASYQTNMLIIVARASELL......PP
  985- 1015 (29.78/13.06)	....STGAAANWDQGIENLLALISDTLlsmvgtPP
 1016- 1037 (30.42/13.49)	QPQQQQAPPAG..........QAQEQL...papPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.33|      10|      27|     679|     691|       6
---------------------------------------------------------------------------
  679-  691 (15.90/15.37)	IGSLDgtrPLWAQ
  709-  718 (20.44/ 9.85)	IGSGD...PLQRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      47.04|      21|     391|     517|     550|       8
---------------------------------------------------------------------------
  517-  525 ( 9.28/ 9.18)	..................CLPSVADWV
  536-  550 ( 6.99/12.70)	EVKSmvySLSPSIRE............
  765-  788 (30.77/ 8.60)	EANT...SVIPMLREriqALDRLFDFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.95|      17|     263|     198|     226|       9
---------------------------------------------------------------------------
  210-  226 (32.63/15.96)	LQLQEFDTMPDPFKKYR
  474-  490 (28.32/14.14)	LLSPEYPSMLETQKKFR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27954 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TLLSMVGTPPQPQQQQAPPAGQAQEQLPAPPPGPAGRFPQQVQPSQQPLQHLQHLQQQQQHHRPPPPPPQQHVPQPGMHGQAQHQGQVQGPRAGMGQNNASVVVID
1006
1111










Molecular Recognition Features






MoRF SequenceStartStop




NANANA