<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27947

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEGIEGAMALDDVDLFGDPVMDNALAGLPARPPPSKPLLQRLDELRTRGCSQAIAWSRQGTIAVIAKDGMSIDLRFIRCRPDNGDWELSEPSPWSAVSQSPSPPPPNHHSTPLSLASAGAPFVHLAWGPQAFPELAIIDALGRVTILSFSVTLNRPYPIVRRWDADVVDDLHAVVGCYWLPLVLQHTKQAIYEHQFYPASGPWHPSPSKSALLCVTTNGTLKLFFLQSNGRLEETAIELESVTSSDDLITHASLCSDKNTLLLALATASRQLRVVRVSLQWGLPQVDKQVPPGSVPLRPSLREGHVAVTTWVQHGPSESPLDASMTQLSHIEILPSASEAQSQPLAPPVVLTVRSYVPQDSSAYHQESQSIIDRWEVLSDQPQSLHPAFEQLSSKDGAGFAPPTKTRLRKLDPIILPKIVVTVHTAQFGRILCFAFSDGTVQFRDRFTMEELYREQNTDTISSPLQVGFQFINDTPCLQVAFSPTNCSFAQLCEDWTVKWNKLHYPTADPSSPLPRTQLRPLAVALSVAASVTGAYQVSNDDVLAVARPFAQMPNFTDAWIRETVSILKVVVDYSEDAHHDQLVRNAYLQACFSMLSHLGFQGDFKPRPFSARFAMLALNLRNMVVLITVASNTPVSIKEKLNPLDDPEVVEALAGWVKWGVDLLSWLVDCLFALLNDSEVMAMLTDPKRFLELARYLRSKKDVSLHLLLCSSTRGFLSAACRRLVHLESISSRTAQFYETNPQLQDPSATATPARPHPALIQAYLKVRRVVSSSVVKMQEFDRLLSGLGKDIQSAYQKTLSGLAAAVKPPQGNLTEEQQQQYHDAFIKKAQTQCELDMLLGENPPPAFRDMLLRFFTTTLPEFRRHTDPAKLFFANYDVLEVEDNARALSARKAAGKYIDVFKRVELVVAGSARGANGQVVDDGGGAGQDGQNMLPAKRNAGGEEVNGHNSSSNNNNAGFVNGSGNGNANGGGGGGDDENGGGGRLWRRCVRCAAVMEDIWSNRPGFNFVLAQQRRCACGGSWVVVPRGS
Length1031
PositionTail
OrganismThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Thermothielavioides> Thermothielavioides terrestris.
Aromaticity0.08
Grand average of hydropathy-0.186
Instability index49.51
Isoelectric point6.20
Molecular weight113051.12
Publications
PubMed=21964414

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364149
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27947
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     418.83|     144|     241|     433|     614|       1
---------------------------------------------------------------------------
  433-  585 (237.98/210.65)	C.FA.FSDGTV..QFRD..RFTMEELYREQNTDtISSPLQV.....GFQfinDTPCLQ.VAFSPTNCSFAQLCEDwtvkwN.KLHYP..TADPSSPLPRTQLRPLAVALSVAASV.................TGAYQVSNDDVLAVARP......FAQMPNFTDAWIR..ETVSILKVVV.DYSEDAHHDQLVR
  671-  855 (180.85/100.53)	ClFAlLNDSEVmaMLTDpkRFLELARYLRSKKD.VSLHLLLcsstrGFL...SAACRRlVHLESISSRTAQFYET.....NpQLQDPsaTATPARPHPALIQAYLKVRRVVSSSVvkmqefdrllsglgkdiQSAYQKTLSGLAAAVKPpqgnltEEQQQQYHDAFIKkaQTQCELDMLLgENPPPAFRDMLLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     231.77|      64|      70|      11|      76|       2
---------------------------------------------------------------------------
   11-   62 (84.40/42.43)	...................DDVDL.FGDPVMDNALAGLP....ARPPP...SKPLLQRLDELRTRGCSQ.AIAWSRQG..TI
   63-  135 (80.78/43.75)	AVIAKDGMSIDLrfircrpDNGDWeLSEPSPWSAVSQSP....SPPPPnhhSTP....L.SLASAGAPFvHLAWGPQAfpEL
  282-  317 (38.04/14.53)	....................................GLPqvdkQVPPG...SVPLRPSLRE....GHVA.VTTWVQHG..PS
  323-  348 (28.56/ 9.31)	ASMTQLSHIEIL................PSASEAQSQ.P....LAPP...................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.86|      16|      16|     926|     941|       3
---------------------------------------------------------------------------
  926-  941 (29.84/16.44)	GGAGQDGQNMLPAKRN
  943-  958 (28.02/15.03)	GGEEVNGHNSSSNNNN
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.79|      10|      46|     911|     920|       6
---------------------------------------------------------------------------
  889-  898 (17.02/10.26)	ALSARKAAGK
  911-  920 (18.77/12.09)	AGSARGANGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27947 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GQVVDDGGGAGQDGQNMLPAKRNAGGEEVNGHNSSSNNNNAGFVNGSGNGNANGGGGGGDDENG
919
982










Molecular Recognition Features






MoRF SequenceStartStop




NANANA