<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27944

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAGGYETNTLLISQVSDISFRIYEPIASQSSTYTFNASDVEDALRSDGHLVYMDAVRRGIWCFYLSSRDSTAATSPERLGLHPRMEVCGYPLGLVADGNLEPIGLLRNKPPGTNAINTPSSSSSTGSALDVGMRSAQSFSFPPPLAVDGKVASTPVGDVKGYGSVPAREIHEFFITAVLSSLTTYFCRAVGAILLNHRSALLPSHAFNSGSLVISLHVSVLQGLVSSADVLRSSLLHAGPTVLAAPFGTFGALQGIVDTETQAADGGFGQTPDTQLNGLRSDRGDRFQQWKATCCRLLQMRGMSPSMLDGCSWLNIHFLQRKPYEQRADGKRTPLVSSGPTAPWPAVLCFRKPKIEPALDISYEKALSGTADNSLDPLTKAKLWCQGVSEREQVVADRKERGAAALVRGHADAELKSHPQANGYSPMALWRSSNGGPQPAAGAVYPTPPDVVQPVGVTPSFEGGTVQSPAGQPGTNAQVGAQAAVQQNAPPSDGFHVGWDGAEPRPGQPANNFSEENIFGDLGEDMFEGNELTDADFNFFDEQPAAVEMDVPLLPDIHPSGLAGSEDRNQNFDELAQAAPGAKETKDVVRSGSPHFTKPELKHARSTLEERRQQTNMESFNLNSTLGIKRNPSPSNLGSVLKRFRGSICPPPTSLPNNPQRPARRRSIFEKVDFDPALSLVRRKYEDEGPFAYRSSGLKDMEKGFSPTGSPLTRNRLPGFSRQRRNLKELPSDIGSILAKLAGNTSSNSPTQPDYGRSDSDDSSWASDSDDASDRVGRASSPAKSSVVRRRPDDDVTSMAASFRELDNISTDSPAYGPVDFSRLSNSEIPEFPLAKYFADPEPVPLRVSISDDDFITVAQILTEQAAGGFLRLFPQRPSSETQDVRRSLIKAIRYSIKGLQKALPRSLAGAAGCQLRPFAEVQDVPLLVQPNGRVQMRPADFPKPGIFSIPAPHVELRRYDTQLSVLPSAVSFWDTLGLAPAQGPKDVVGLCVLPQSESMRDNASAFLDRVKSTYESMRLGTFERLPPAGDIADGVVLLSTDPEIASPGLNLPPARSAYTDRMASLAVALASSPVSGKNIVVYFAYTPENPGSIVDLCSAFQELLEQYKRCMSDRKKKVANQLVLQLVPVDAVASETFLVVLSPSECARLCIETYDRCTLFGGPTPVAAIVLERALPRGIDFKLAATPSPSLLRENSCMHIAYARSVDERWIAAAWTDNRGSTQTTAAYCLGRRGKPLSRQLAEVIHEMWETTYDLISSCKVHWRLVITKCGPMDQHEMELWSGMAQAENRATISLVLLTVDTDPSLQLIPPAGTIPQSAPSAFYTTPASTPQPLSGVSPDQSGNNPSTPIGTTTPGGDNNPTTTTSSSSQPQSHAQPAPDPDAPDTTLVDATETTWGVVVSHRLNNSASLTDLNPALASGYLVKRTGARAEDAPVAMEVNVVFSDNARALYDGLLREMLTYFRGLGTLARVRGVVERDVDVRPWHVAVVEKAVRALYLLM
Length1502
PositionKinase
OrganismThielavia terrestris (strain ATCC 38088 / NRRL 8126) (Acremonium alabamense)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Thermothielavioides> Thermothielavioides terrestris.
Aromaticity0.07
Grand average of hydropathy-0.307
Instability index51.61
Isoelectric point5.67
Molecular weight162023.44
Publications
PubMed=21964414

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27944
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.65|      24|      26|     632|     656|       1
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  632-  656 (41.05/21.17)	NPS.PSNLGSVLKRFRGSiCPPPTSL
  659-  681 (33.29/13.08)	NPQrPARRRSIFEKVD...FDPALSL
  729-  747 (26.31/ 8.99)	KEL.PSDIGSILAKLAGN.....TS.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     425.32|      92|     100|     189|     280|       2
---------------------------------------------------------------------------
  134-  224 (103.11/42.53)	.......MRS....AQSFSFPPPL..........AVD.GKVASTP..VGDVKGYGSVPAREIHEF........fitavlsslttyfcRAVGAILLNHRSALLPSHAFNSGSLVISLHVSVLQG
  225-  324 (131.33/56.07)	LVSSADVLRSSLLHAGPTVLAAPF.GT...F..GALQ.GIVDTET..QAADGGFGQTPDTQLNGL...........rsdrgdrfqqwKATCCRLLQMRG.MSPS.MLDGCSW.LNIHFLQRKP
  325-  437 (109.76/45.72)	YEQRADGKRTPLVSSGPT...APW.PAvlcFrkPKIE.PALDISY..EKALSG...TADNSLDPLtkaklwcqgvsereqvvadrkeRGAAALVRGHADAELKSHPQANGYSPMALWRSSNGG
  438-  489 (48.74/16.44)	PQPAAGAVYPT.....PPDVVQPV.GV...T..PSFEgGTVQSPAgqPGTNAQVGAQAAVQQN............................................................
 1318- 1354 (32.38/ 8.58)	PQSAPSAFYTT.....PASTPQPLsGV...S..PDQS.GNNPSTP..IGT.........................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.93|      39|      39|     906|     944|       3
---------------------------------------------------------------------------
  864-  902 (43.58/20.34)	TEQAA.GGflRLFPQRPS.SETQDVRRSLIKAIRYSIKGLQ..
  907-  944 (60.51/31.25)	.RSLA.GA..AGCQLRPF.AEVQDVPLLVQPNGRVQMRPADFP
  946-  986 (49.85/24.38)	PGIFSiPA..PHVELRRYdTQLSVLPSAVSFWDTLGLAPAQGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.50|      31|      45|    1422|    1453|       4
---------------------------------------------------------------------------
 1422- 1453 (48.34/37.45)	GYLVKRTGARAEDAPV.AMEVNVVfSDNARALY
 1468- 1499 (49.16/32.56)	GTLARVRGVVERDVDVrPWHVAVV.EKAVRALY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.23|      31|      39|    1179|    1212|       5
---------------------------------------------------------------------------
 1179- 1212 (49.89/38.26)	RGidfKLAATPSPSLLRENSCMHIAYARSVDERW
 1221- 1251 (55.34/33.91)	RG...STQTTAAYCLGRRGKPLSRQLAEVIHEMW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.40|      31|      33|     751|     783|       8
---------------------------------------------------------------------------
  751-  783 (46.97/33.48)	PTQPDYGRSDSDDSSWASdSDDASDRVGrASSP
  785-  815 (52.43/28.50)	KSSVVRRRPDDDVTSMAA.SFRELDNIS.TDSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.89|      21|      42|    1037|    1062|      17
---------------------------------------------------------------------------
 1037- 1062 (26.50/25.65)	VVLLSTDPEiaSPG..LNLppaRSAYTD
 1082- 1104 (34.39/16.94)	VVYFAYTPE..NPGsiVDL...CSAFQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.75|      10|      21|    1357|    1366|      18
---------------------------------------------------------------------------
 1357- 1366 (20.77/11.82)	PGGD.NNPTTT
 1379- 1389 (15.98/ 6.90)	PAPDpDAPDTT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27944 with Med13 domain of Kingdom Fungi
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