<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27934

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAGEYETNTLLISNLSAISFRIYEPIAAQSSTYTFNASDVEDALRSDGHLVYMDAVRRGIWCFYLFSGDSTPASHSERLGLHDRMEVCGYPLGVVGDGNLEPVGLLKNRPLGTSTINTPSSSSSNGSALDMTVRGAQSFSFPPTPVVVDGKVASTPVGNAKGYGSVPAREIYQFFITAVLSSLTSYFCRAVGAILLNSRSALLPPQVFNSGDADWGQAPRSSALATFRTYLTTTGSLVISLHVSILQGLVSSADVLRSSLLHAGPTVLAAPFGTFGTLQGVVDTENQVVDSGFGQSPDTQVSRLRSDHSDKFLQLKTTCCKLLQMSGMSPSLLDGCPWLNIHFFQRKPYEQRPDGKRTPLVGSGTTAPWPAVLCFRKRKIETMMDVSLEKALPATTGTTAHLDPLDQAKLWCQGVSEREDVVSKRKKEKDVASELDHPEPSDMKGNPQTNGFSPMALWRGSANGGPPGATGTMYPTPPDGVQLSGVTPSFDNGQTQSPDGQPTTNAAGNNLTATQRDPPAPDGFNAGWEGADTRLEQPTASFGEDNLFGDLGEDMFEGNELTDADFNFFDENPGSGEMDLTGLPELETSTMGNQENDNHQFQEQTEGSAGTDSKMDARPISPQFTKPELRRARSTLAEEHRQLTNIQSSNRNSAIGIKRNPSPFNRETVFKRICASIRPPSLTISKRREPFRRPSLFEKVDFDPALSPAIRKYGERGLFDFTSAALKGRENRLLPPGGPLTPGRGSGSIKQRKNLKELPSDISSILAKLASANSNSSKQQDDSRSESDDDSSPSLDEDAMEQLGRASSPAKSSVLRRRPEDDVISMAASFRELENISADSPGCGPVDLSRLSSSEIPDFSLSKYFADPEPVPLRMSSSDEDFITVAQILTEQAASGFLKLATPRPSSEVQDLRRSLVKATRCSINGLQKALPRSLAAAVGCRLRPLAEVQDVPLLVQPNGRVQVRPAEFPKPSIFLIPTPHVELRRYETQLSVLPSAVSFWDTLGLGPVQGPKSVVAVCIVPQAQGMQDNASAFLDRVQSTYESLHLGPFERLPTIGNIVDGLVLLSSDHDAVSPGLNQPRARSAYTDQMTNLAMSLSGLSMSERNLVVYFAYAPDNPGSIVDSCSAFQELFEQYKRCMADRKKQVTNELVLQLVPLDAVATETSLVVLSPSDCARLCVETYDRCALFGGPMPSPAIMLERALPRGIDFKLAATPSPNLLRENSCIHVAYARSVDERWVTAAWTDNRGSTQSMASYCLGRRGRPLSRALGDALHEIWETTHDLISTCKVHWRVVVTKCGPMDQHEMELWTAMAQTESRANVSLVLLTVETDPSLQLIPPAATIPLSAPSVFYTTPVSTPQPPSVLSPDQSGNPSTPVGNTGTPAGATTPGGDSSQQQQQQQQQPASQTSQSDADGDTTLVDVTETTWGVVVSHRLNNSASLTDLNPALASGYLVKRSGPRQDDAPVAMEVNVVYSDNARAMYDVLLREMLTYFRGLGTLARARGVTERDVDVRPWHVAVVEKAVRALYLLM
Length1532
PositionKinase
OrganismMyceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Thermothelomyces.
Aromaticity0.06
Grand average of hydropathy-0.341
Instability index50.99
Isoelectric point5.33
Molecular weight165861.46
Publications
PubMed=21964414

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27934
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.51|      35|      35|     438|     472|       1
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  438-  472 (71.42/34.15)	HPEPSDMKGNPQTNGFSPMALWRG...SANGG.P.PGATG
  475-  509 (49.88/21.59)	YPTPPD...GVQLSGVTP.SFDNGqtqSPDGQ.PtTNAAG
 1368- 1391 (29.21/ 9.53)	....PDQSGNPST....PVG.NTG...TPAGAtT.PG...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     540.46|     168|     271|     568|     740|       2
---------------------------------------------------------------------------
  568-  740 (279.42/169.01)	NFFDENPGSGEMDLTGL..PELETSTMGNQENDNHQFQEQTeGSAGTDSKMDARPISPQ....FTKPELRRARSTLAEEHRQLTNiqsSNRNSAIGIKRN.PSPFNRETVFK.RICASIRPPSLTISKRREPFRRPSLFEK..VDFDPALSPAIRKYgERGLFDFTSAALKGRENRLLPPGGP
  836- 1013 (261.04/144.82)	NISADSPGCGPVDLSRLssSEIPDFSLSKYFADPEPVPLRM.SSSDEDFITVAQILTEQaasgFLKLATPRPSSEVQDLRRSLVK...ATRCSINGLQKAlPRSLAAAVGCRlRPLAEVQDVPLLVQPNGRVQVRPAEFPKpsIFLIPTPHVELRRY.ETQLSVLPSAVSFWDTLGLGPVQGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.69|      18|      46|      72|      90|       3
---------------------------------------------------------------------------
   72-   90 (30.52/21.40)	TPASHSERLGLHDrMEVCG
  119-  136 (32.17/17.76)	TPSSSSSNGSALD.MTVRG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.94|      25|      30|     331|     355|       4
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  331-  355 (50.34/34.86)	PSLLDG..CPWLNIHFFQRKPYEQRPD
  360-  386 (42.60/28.14)	PLVGSGttAPWPAVLCFRKRKIETMMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.35|      24|     270|     271|     294|       8
---------------------------------------------------------------------------
  271-  294 (43.53/27.49)	APFGT...FGTLQGVVDTENQVVDSGF
  541-  567 (38.82/23.69)	ASFGEdnlFGDLGEDMFEGNELTDADF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      14|      51|      92|     105|       9
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   92-  105 (27.40/13.34)	PLGVVGDGNL..EPVG
  144-  159 (22.58/ 9.78)	PTPVVVDGKVasTPVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.20|      20|      31|     770|     790|      13
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  770-  790 (28.33/18.79)	LASAnSNSSKQQDDSRSESDD
  804-  823 (33.87/18.19)	LGRA.SSPAKSSVLRRRPEDD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27934 with Med13 domain of Kingdom Fungi
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