Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MDDSTPPPGPNGGGPIDIHQPFTPGERIQQLSETDQDIASLLVHLSAAMRALATPPGTTVSETGNNNNSSNNNSSTIATGDPDLESSEPAPATGNDPVSAFNAAQTAFFNTLDRVDKHLTRQILALEEAGIITLKNTAAGSGTAAGTAAAEGTPQGGEGAAGGPSGTQQQQPQQQSPEGGAGDAAKARVAGPRRLEPDGMGRYGNLDVGKLNMASSTVERDMERELWRRAREELAKVVGDAGGGGGDPMET |
Length | 251 |
Position | Head |
Organism | Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Thermothelomyces. |
Aromaticity | 0.02 |
Grand average of hydropathy | -0.647 |
Instability index | 40.67 |
Isoelectric point | 4.51 |
Molecular weight | 25621.54 |
Publications | PubMed=21964414 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27929 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 69.76| 19| 45| 139| 162| 1 --------------------------------------------------------------------------- 144- 162 (33.04/15.82) AAGTAAAEGTPQGGEGAAG 164- 182 (36.72/ 9.79) PSGTQQQQPQQQSPEGGAG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 53.57| 18| 21| 183| 202| 5 --------------------------------------------------------------------------- 183- 202 (22.57/23.53) DAAKARVAGpRRLEPDgMGR 207- 224 (31.00/19.13) DVGKLNMAS.STVERD.MER --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AAKARVAGPRRLE 2) QPFTPGERI 3) RDMERELWRRAREELAKVVGD | 184 20 220 | 196 28 240 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab