<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27925

Description Uncharacterized protein
SequenceMTSRTPLGVQQRPPQHKLNGPTLSQRPGAAHQRALSQQSQPQPQPQPQQQQQQQQQQQQQQQQQQQHPSLSPVRKDTPFYDLTSADATVDGPSARHGATRRGGSRLKLELSHDSADSLQQHAAVTESPGAAESSKAFTPSRIMPPTDSSELGDMSPHLSAHPLSVEIDAPLPLPRRPPPFVPSAPRREMPPPPTSANPPKRDARPKPFAVDPPAAAPRYATRPDSQTKTGTPKIAYADFYPWTGNHPEDHFSDNVIRHGYYDKGLFSTAETQSAKNILFPALKHKTGLTALSSVFTAVLGQRRHNGQITAPSTFKPPPRVTLTDTKRELWLKDLANPAISLRRLSRTIPHGIRGKVLLEQCLNKRVPTDRAVWLIKCVGANEIRATKRKGVSTLVMGGETRWIKDWTVSVEQFIENVYFSFGEDDWKAKVHYTTRLAAHLYAECLLDREHYSEWLVSNLENSPESKLPMWMLITQLYWKDLLKLRKYGRRLVTALVSHHHLLYNHPDKDILLPLLKNLTQCLNTLLLSSPENFVSPSAWSKYRDALKACLPAGDEARHNAFGAINLRNEQLAAAANRSQPAARHILVRMLDGTLQAPMPNELPAQCWGISKDKDALARALLEWCTSLYRPGIAKVYVTSRILQHWSTTGLDSTTAVLAFLETDACEEEERKSLLYHVVCELVRSGLFSVSRYIQWLIARGGLRDPDLVSRDGPAATRLLVEVPVHALAPSQRNSRAEILRRASFSVMEAAADAELAVMHLKHVLGIPVDLAGLKPLSLAKLTKRIASADRALKAELGYWLWSTTLAAHAEENDGDGEGSPALETSPANFYVVRSVMEAAEDFSMFGDVLETLAKRSGVDVLAAIADTVSRHFFVFSALGITAALFRSLHLRLKAAVQEHGFALRPLLASLVTLAPRIPGMEEAASRLKRDLALNDRQNPVDACSPVSDTVVARLQDDAGELHEEIEKLLAGGSSVDRNTMERLFQTLVQRLQASWSKAADKQRAYSSLLGRLRLFNTQHFDGLMVKWLLSLRTLANRPSILRIFPLLVSVGCLDMGAILATASDIPAGQGVPTARVLTTTGAAVPQVVQITYRTRYMQEVLQLLTAPIRCSDLLTADEVYRFSIFQDQAVRECPKEVLGLIFLASAEYSYAKAQNDLEGLPLECESVRQSLLDLLKRLVLRDATGVARTLGMKSPNSQASGWIDSVTTKLLVPTADAHTRISFDQVLELTNEFTLPFCQVKLALSLSPGEQSSQDSADRQQSHVELFGNAMDKAISAGNISWVGMLSCLSPDITQHLKVRAQNRFLELMPSLRKPPPTDDDALAQNLQMAENLLSVIDAIMRGSSAGGARQSQLPPAVVDKLVDLWELLAAPLDGDNGGSGDHGKRSNDPDMMEIDTEPAAAATATTTTTTIEATVAATTTNPKTAVLAHWLPLLLNLVTLHAHTLDPSRANNEVRAKVLVACAGLMQELDALPLPPPPPRHSHHMPGPLPADAASLSRRVFDLACLLVDNLPEEARMMCVRAVAGCAGGDARLRYLFSFTSSTSGTGAAADGGCGDSGLMLAHREKAAGGRSAGAAAGGGGGGNGGGGGGAMFGGLLGTPASLWAVDRGQATERLSVFQYRRWEMLNEPTPNVGENDTALSLALFEARKVQ
Length1652
PositionKinase
OrganismMyceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Thermothelomyces.
Aromaticity0.06
Grand average of hydropathy-0.246
Instability index51.99
Isoelectric point8.21
Molecular weight180189.38
Publications
PubMed=21964414

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27925
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     226.17|      80|     151|     539|     654|       1
---------------------------------------------------------------------------
  539-  632 (119.79/81.07)	WSKYRDALKACLpAGDEARHNAFgAIN...........LRNEQLAAAANRSQPAARHILVRMLdgtlqapmPNEL.......PAQCWGiskdKDALARALLEWCTSLYRPGI
  666-  720 (47.36/35.62)	EEEERKSLLYHV.VCELVRSGLF.SVSryiqwliarggLRDPDL...VSRDGPAATRLLV....................................................
 1494- 1549 (59.01/20.79)	............................................AASLSRRVFDLACLLVDNL........PEEArmmcvraVAGCAG....GDARLRYLFSFTSSTSGTGA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     344.60|     106|     123|     805|     920|       2
---------------------------------------------------------------------------
  744-  788 (26.88/ 7.39)	.........................................................................FSVMEAAAdAELAVMHLKhvLGIPVDLA..G..LKPL..SLAKLTKRIASA
  805-  920 (156.89/121.03)	LAAHAEENDGDGeGSPALETspanfYVVRSVMEAAEdfsMFGDVLETLAKRSGVD..VLAAIADT.VSRHFFVFSALGITA.ALFRSLHLR..LKAAVQEH..GFALRPLLaSLVTLAPRIPGM
  931- 1040 (160.83/97.85)	LALNDRQNPVDA.CSPVSDT.....VVARLQDDAGE...LHEEIEKLLAGGSSVDrnTMERLFQTlVQRLQASWSKAADKQ.RAYSSLLGR..LRLFNTQHfdGLMVKWLL.SLRTLANR.PSI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     382.27|      95|     161|       6|     102|       3
---------------------------------------------------------------------------
    6-  102 (155.80/79.11)	PLGVQQRPPQHKLNGPTLSQRPGAAHQRALSQQSQPQP...QPQPQQQQQQQQQQQQQQQQQQQHPSLSpVRKDTPFYDLTS...ADATVDgPSARHGATRRG
  107-  170 (84.46/35.41)	KLELSHDSADSLQQHAAVTESPGAA.......ESSKAF...TPSRIMPPTDSSELGDMSPHLSAHP.LS.VEIDAP...........................
  171-  264 (142.01/65.07)	.LPLPRRPPPFVPSAPRREMPPPPTSANPPKRDARPKPfavDPPAAAPRYATRPDSQTKTGT...PKIA..YAD..FYPWTGnhpEDHFSD.NVIRHGYYDKG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.55|      10|      16|     431|     440|       4
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  431-  440 (18.21/10.80)	HYTTRLAAHL
  450-  459 (19.34/11.97)	HYSEWLVSNL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.17|      15|      16|     378|     392|       6
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  378-  392 (24.73/12.01)	VGANEIRATKRKGVS
  395-  409 (29.44/15.43)	VMGGETRWIKDWTVS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.95|      28|     157|    1289|    1317|       8
---------------------------------------------------------------------------
  291-  318 (51.97/30.53)	LSSVFTAVLGQRRHNGQI.TAPSTFKPPP
 1289- 1317 (47.98/32.03)	LSPDITQHLKVRAQNRFLeLMPSLRKPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.35|      22|     918|     506|     532|       9
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  511-  532 (39.64/30.90)	LLPLLKNL.....TQCLNTLLLSSPEN
 1171- 1196 (25.94/ 7.65)	LLDLLKRLvlrdaTGVARTLGMKSPN.
 1432- 1453 (28.77/13.02)	.LPLLLNL....vTLHAHTLDPSRANN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27925 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DGDNGGSGDHGKRSNDPDMMEIDTEPAAAATATTTTTTIEATVAAT
2) MTSRTPLGVQQRPPQHKLNGPTLSQRPGAAHQRALSQQSQPQPQPQPQQQQQQQQQQQQQQQQQQQHPSLSPVRKDTPFYDLTSADATVDGPSARHGATRRGGSRLKLELSHDSADSLQQHAAVTESPGAAESSKAFTPSRIMPPTDSSELGDMSPHLSAHPLSVEIDAPLPLPRRPPPFVPSAPRREMPPPPTSANPPKRDARPKPFAVDPPAAAPRYATRPDSQTKTGTPKIAYADF
1374
1
1419
239










Molecular Recognition Features






MoRF SequenceStartStop




1) DTPFYDLT
2) KIAYAD
3) RLKLELSH
4) RPGAAHQRALSQQ
76
233
105
26
83
238
112
38