<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27924

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDDRPFSLQPRTAPQQGPRSISEFIQRANAQPGGFRALNWADVRRELEASQNGGGDHDVDMTGDGSEADSETAETKDIAAAREEILRAIHQTHQISMFALDFVSLLLSKENPALAVSTLSPGLRDMVGIGTLGATMLNAPTPVAQSRVPDHKMVSIGKRLMDLNRAADTALATSKRLQREIDLETKYWSEVLGVGEGGWQTFRLPHEPQTLGVKFGFSNTAPEFKASGIAPLRRAEDGSVRLEHGVMGRGSKRIQVKILEKGVVVGKSSLPPPLPPDAPLQDRVKESRDTVFAQELWYEVNREARSGLDDIVRIGKSTATYDLDPATSISLQLVTLGEEDATAEQQTGPQDAWADAVSVILGLLLTNAHRVNELKRSEPTFKKGPTPPYFILRPLIAYHRYSQSVQKCAEFLTALISVLRSAGVASSVAMREPPLALSPGNSRTVTPASTSLATLLLKPPAVHFDLTITPTSRLRILLKPALLSGASYAVSMLPPLQQPSQPPHSTAVNPLPAFCPAASEDYLYLPQLVTYLCEAVPCALAAAYFERAVTLPGRQRAAAAAQATQDDSAADQEGGQQQGPREGEALWGMDVLGKGIVDLDTGGEYGVHFDIVREEHDGDHKAAGAGRLELRVKADYLEPTAGEGEMVGGVGGGGGGGGAKKVHREWRWPGAGESVGVVVKQVLSNGPVE
Length689
PositionHead
OrganismMyceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Thermothelomyces.
Aromaticity0.06
Grand average of hydropathy-0.277
Instability index44.15
Isoelectric point5.66
Molecular weight73819.62
Publications
PubMed=21964414

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27924
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     562.90|     137|     312|       6|     143|       1
---------------------------------------------------------------------------
    7-  143 (223.91/144.01)	SLQPRTAPQQGPRSISEFIQRANAQPGGFRALNWADVRRELEASQNGGG..DHDVDMTGDGSEADSETAETKDIAAAREEILRAIHQTHQ....ISMFALDFVSLLLSK........ENPALAVSTLSPG.LRDMVGIGTLGATMLNAPTPV
  205-  320 (155.60/96.12)	.......PHE.PQTLGVKFGFSNTAP.EFKASGIAPLRR....AEDGSVrlEHGV..MGRGSKRIQVKILEKGVVVGKSSLPPPLPPDAP....LQDRVKESRDTVFAQ........ELWYEVNREARSG.LDDIVRIGKSTAT........
  322-  462 (183.38/112.14)	DLDPATSISLQLVTLGEEDATAEQQTGPQDA..WADAVSVILGLLLTNA...HRVNEL.KRSEPTFKKGPTPPYFILRPLI..AYHRYSQsvqkCAEFLTALISVLRSAgvassvamREPPLA...LSPGnSRTVTPASTSLATLLLKPPAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.95|      25|      29|     624|     650|       2
---------------------------------------------------------------------------
  624-  650 (40.03/30.86)	GAGRLELRVKADYLEPtaGEGEMVGGV
  654-  678 (48.92/31.58)	GGGGGAKKVHREWRWP..GAGESVGVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.34|      18|      24|     509|     526|       3
---------------------------------------------------------------------------
  480-  494 (19.90/ 9.27)	...P.ALLSGASYAVSMLP
  509-  526 (34.21/21.38)	NPLP.AFCPAASEDYLYLP
  534-  552 (24.23/12.94)	EAVPcALAAAYFERAVTLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27924 with Med17 domain of Kingdom Fungi
Unable to open file!