<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27920

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDSGMHDSTPPDKARGSIVNGVSGDDVPVKSESPTTGNKVVDNGPAIDYSKLGSSLRDVKKEEPPDELQHITEGVMPLSLLLTRLAQFSHMKLQELILELASKPLPEHTRNGNAKGPINSGINGSVNTANGGAKMPGNVFEDTSPESLDKKTMLLKFIQDLHSRWVKALVITEWARNADEVGKLIDLRIHLAEKLELYNKAFWNMIHVKQEMAFAKVPSPDLKTALEVLSAGAVHWMPDFGYLPKPPLEAQEISHWLNEIEVTLHMRLQLHEYEQIPEPWKQYKIDNGRVTFTVPGEFEVDLTISDEDFGTQFWFLDYRPLFSPAPPKLSDGARGFIEGRVNKILETEGLPGCYKYLHEMALTAKIGEFTRQAVELNRTGLWAETLRVERLNRALGIQYWVQSSHTQGSESWILLGTHSGKNSEGGSDPNSPSRLVLQWFRDGKKVKDADIPFDADNISTEKLLTAVISRHIQHLLSTIFNTLQGKPRYARKQGKLALRISDQPGTDSALTMQLLGKADAVLSIGTWSGNFYFVDRSLIGLEWAHRLNSSRNPATEGPGMLEALRWAYTVRYLRTLPKPADWVILPQAPVPSDEVKRVVYSHAPTTREPFYAMWMRNTRWSAQWFAMMSLSLGGDRWWLIEVTAEGHGLPGFRISTFTELPITPTDLLPPAASLIPKLTKHTANIMAQIDDLRGLHQQRVPHTASKFRESGSLTTYVLSADMLARQPGSDDASRTTWAAKFIPLAYKGPAPVPISEYRELLADLRSPQRQPARQRVMVEAKVDVTNRSRLQLLERNLDRDVLYDHRAGQFILRLQPDSSSGAIPLLRARMQALDRLVGIVDGLGRGGKHVTPERITLREVVFSYSAKASAIRAPELSQPDQSSSSDGNTQRSWKVRLGLAGEQGVNVMLEPGNPHLRVLDFLRATANSPQFKKLPSWLLFTLPLFEALERLQISWDAVLAKEQGTCYVFHKSMDWVTIRFALTGAKNRRLHLDIRPRDKGGELTWHVYRPATDTNVNNENDEFNRVLKQRVWSTNGRGFKGLMNGAAATWDDGIGNLLALIDEALQSLAGTPAPPQQAPAQAPQPTQRPQQPQALELQNQQQPQQPQQPQQQQQQQQQQQQQQQPALPLHGSGAPGRFPHPLQQGQQAQYQQQQQQQQQQLQQARLQQQMHGQAQAQGQQRGGGVGNNNAPVVVLD
Length1196
PositionTail
OrganismMyceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Thermothelomyces.
Aromaticity0.07
Grand average of hydropathy-0.511
Instability index48.52
Isoelectric point8.77
Molecular weight133861.26
Publications
PubMed=21964414

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27920
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     129.48|      13|      14|    1081|    1093|       1
---------------------------------------------------------------------------
 1081- 1093 (26.17/11.25)	QAPQPTQRPQQPQ
 1098- 1110 (28.99/13.37)	QNQQQPQQPQQPQ
 1111- 1123 (27.10/11.95)	QQQQQQQQQQQQQ
 1143- 1155 (25.10/10.45)	QQGQQAQYQQQQQ
 1156- 1168 (22.12/ 8.20)	QQQQQLQQARLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.24|      47|      52|     515|     566|       2
---------------------------------------------------------------------------
  520-  566 (82.99/51.91)	AVLSIGTW..SGNFY.FVDRSLIGLEWAHRLNSSRNPATEGP..GM.LEALRW
  569-  620 (65.69/31.14)	TVRYLRTLpkPADWV.ILPQAPVPSDEVKRVVYSHAPTTREPfyAMwMRNTRW
  621-  653 (41.56/18.14)	..........SAQWFaMMSLSLGGDRW..WL...IEVTAEGH..G..LPGFR.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.48|      21|      53|       1|      22|       3
---------------------------------------------------------------------------
    1-   22 (34.96/24.93)	MDSGMHD...STPPDKARgSIVNGV
   52-   75 (32.52/17.85)	LGSSLRDvkkEEPPDELQ.HITEGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.22|      26|      56|     195|     220|       5
---------------------------------------------------------------------------
  195-  220 (48.16/34.69)	LELYNKAFW.NMI....HVK.QEMAFAKVPSP
  248-  279 (35.06/23.08)	LEAQEISHWlNEIevtlHMRlQLHEYEQIPEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.75|      40|      58|     835|     879|       8
---------------------------------------------------------------------------
  794-  824 (25.68/10.38)	.....................ERNLDRDVLYDHRAGQFILRlQPDSSSgaiP
  835-  879 (63.40/53.30)	RLvgivdGL.GRGGKHV..TPERITLREVVFSYSAKASAIR.APELSQ...P
  896-  935 (48.67/30.02)	RL.....GLaGEQGVNVmlEPGNPHLRVLDF...LRATA.N.SPQFKK..lP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27920 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IDEALQSLAGTPAPPQQAPAQAPQPTQRPQQPQALELQNQQQPQQPQQPQQQQQQQQQQQQQQQPALPLHGSGAPGRFPHPLQQGQQAQYQQQQQQQQQQLQQARLQQQMHGQAQAQGQQRGGGVGNNNAPVVVLD
2) MDSGMHDSTPPDKARGSIVNGVSGDDVPVKSESPTTGNKVVDNGPAID
3) SKPLPEHTRNGNAKGPINSGINGSVNTANGGAKMPGNVFEDT
1061
1
102
1196
48
143










Molecular Recognition Features






MoRF SequenceStartStop




1) KARGSI
13
18