<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27919

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMAPPVVLTVRSYVPEDTSSYHQETQSIIDRWEILLDQPQALHPAFEQLASKNGTASVPPTMTRLRKLEPIVLPKVIVTVTTAQSGRVLCFAFSDGTVQYRNRFTMEEIYNESDTESIMHPLQVGFHFTNDTPCLQVAFSPTNCSFVQLCEDLTVKWNRLHYPLEDQGASLESADQKAVLAALTVALSATLNQGSGSCDDILAMARPFDRIPDFASAWVREMVNMFKIVVDYSEAAHHEQLVKNTPLQHCLSVISHLSFRGDFKPRSRSGRFAMLALGIRSVIVVLTVAANTSMSMRERGNPMDDPDVVDAVTGCARWGTSLLAWLTDSLFQLLEDPEMAAMLNSPKRFPELAKYLESKNHVALQLLLCSFTRGCLSALCRRLQLVESVSNRTAQYYETRFQQQQQQQQQQQQQDSAAGAAASSRPHPALVQAYQRMERVMSSALVKVSWFDRILSELSSDIQAAYQKSLSGLVAANVKPQAPNLTEQQQQQQNELFIKKAQAHFELDMLLGQNPPPSFREVLLKLFSVTLPAFRNQTDRAKLYFASYDLLEVEDSPVTLAKRKAAGKYVDVFKRVELVVGPRPKRAASPEGGSNAAEGHHGSAAQRKGAAGGEETASAAGANGIGEDNGMASYRAALMGSWTGIGNDTGPQWRRCVRCAAVMSDLFTTKPGYNFVLSQQRKCVCGGSWGTLPRGT
Length695
PositionTail
OrganismMyceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799) (Sporotrichum thermophile)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Thermothelomyces.
Aromaticity0.08
Grand average of hydropathy-0.250
Instability index41.79
Isoelectric point7.55
Molecular weight76721.41
Publications
PubMed=21964414

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27919
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.59|      73|      78|     339|     414|       1
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  339-  414 (116.50/101.66)	AAMLNSPKRFPELAK.YLESKNHVALQLLLCS.FTRgCLSALCRRLQLV..ESVSNRTAQyyETRFQQQQQQQQQQQQQD
  417-  493 (107.09/80.16)	AGAAASSRPHPALVQaYQRMERVMSSALVKVSwFDR.ILSELSSDIQAAyqKSLSGLVAA..NVKPQAPNLTEQQQQQQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.68|      24|      25|     635|     658|       2
---------------------------------------------------------------------------
  623-  641 (30.31/15.61)	.GIG.EDNGM....ASYRAALMGSW
  642-  665 (48.68/29.11)	TGIG.NDTGPQWRRCVRCAAVMSDL
  668-  684 (18.69/ 7.07)	TKPGyNFVLSQQRKCV.C.......
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27919 with Med16 domain of Kingdom Fungi
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