<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27916

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMELPETCLTNVFKIDNLSEVSYSVYRISSTFGSSPAWRVLSKAETNLRRRGKCVTTCSDSSELWLFQIDNHDTDIAFTSDSGYNSYDGSGTGEKGWEPMVWGLEEKTKEVLNIHEIFEALRPTPSEKPEDLFQLQTLSQIDPLISPGTQLDPIDLSGAHRDVYMLQQLSKQRGSNMSMSAVGSPVSASRHGSSTTGTPHPATTRPVSKQEMVGQKLLLAMMSLLSYRLASSFSWLPLNLCTFLPKFKKGPDAEPEILSYSPISHGPTIITTVSLGLSDDGSLHVTPKTISQSALQRLSNTDLSDTAETDVWLAPGGVIGRHMPKSSIDGLSQATPEWKAFVLKSLADRGVDIEQPGLTKWAKIGVWSDIEGLIEIFWPTSLVFVRKYGGSDIDSYPAISPTGAVDFKLGTNVDELNDLATQLTWYNAGDSLEFAEVWLSGLASRDAEKKRRLEARNKAIPVMDVDRKPPFAAAPTTDRSGTVYPTPPGGLSGNDSHPTPGGPTTAPTPGQTKVAEEPIPVVEPPTAPPTAEATVNGADMDLDDNWMKGDSTKVNDDIFGGQGVGIGDDLFDIDITEDDFGFFDEVGGDGGFADMGLEKPQVSTDLQPRPTTSHLSENMNDLNLGFTNIGSYVNDKLLDDMDLDVDDIGAAMDMQAEMQKDPTPTQAGSEQSSSQPNGQGHKSVRLETQSDDTQHIIVQVETPPLSPQRAMKLLLLDPQSPRGAPPPSKGRLVLPFSRRKSLYSPVDFASFMERSDEKYMAGGRFFCAEDESSPRKAPSEDRRFSATFPRVKKYRNSRRPLSRDIMFLEDDEDRSDLIPDTGSSDEESSSTDEYESGDEEMFEIRNEGAQDNSPYSTSPEGIRQGLKRKRIPSERDYWGGGNKAHGVEALNHSDKLDGAPEWADMANVNDKDIDNLSSAQRTLCDFISTDIALDGVFKFIPDNDDISNRLSSQDFSHVVGLLQEQIVWNTYLISTFCPGSPSFGRISSIEFDANGINDRAEQTLRLRKQSMRHQDDMEDLLTDLFGTLTTRCSLETLVYGAIGRPKNSIYGVSPGLMDPHGLSTGLTPINRPKSSSDANSSPSLLFKISAPHVHVHRNATMPNSAIELLPPALHFWDTFGLTPHSGPKDLLMAAVFPIDSGLATAARVYLEGFSSTYENCRLGEILPVKTSQILDGLHGIAFQGQGKQQTIDEKTMLRRYCDGIIRLGETLVEIEDELQNVVLFVVNPFDTPSSVLEICTAFHMLKKAYVSALNSSLRIFPNNIILQIVPIKNMAVYDGLVVQSHNQSIRCALEVYERCTLTIQDHLSQTFPQETYSPSVTLAKLPPKSIAFRVSSDPSPAILQENMCLHMAYAQSIDERWISVAWGDDCGDIKEVGNFCLGMPGTVVLRAFEDVCREIWAVTNKIISKKRVHWRISLVKVGAIDDDEIEFWMKLSHDCPVPNTLTVFSSDPSPPLTFKYAIPSIMPQAFNGQAQLVGTPGATPQSSGVSPDQFGASSSQGGALTPGDTPAPEVDNDMALVDFTDETWGALLQHPLNNSDSTIVTRPALASGYLIKRSGPNETDEPAVLAVSLIRVGQRGLGVSASMAQQQPPVISKSNEDVLREILTQYRGLVTLAQHFGVTDMMKEVLPWHIAAVMKCRDVFSCVL
Length1647
PositionKinase
OrganismArthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491) (Nematode-trapping fungus) (Didymozoophaga oligospora)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Orbiliomycetes> Orbiliales> Orbiliaceae> Orbilia> Arthrobotrys oligospora.
Aromaticity0.07
Grand average of hydropathy-0.347
Instability index48.51
Isoelectric point4.82
Molecular weight180363.64
Publications
PubMed=21909256

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27916
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.02|      41|      58|    1053|    1109|       1
---------------------------------------------------------------------------
 1044- 1096 (60.39/41.06)	PKNSIYGVSPGLMDPHGLstGLTPINRPK..........SSSDAnsspsllfkiSAPHVHVHR
 1101- 1151 (65.63/33.14)	PNSAIELLPPALHFWDTF..GLTPHSGPKdllmaavfpiDSGLA..........TAARVYLEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     130.16|      24|      58|     302|     325|       3
---------------------------------------------------------------------------
  276-  297 (29.68/15.91)	LSDDGSLHV..TPKTISQSALQRL
  302-  325 (40.85/25.05)	LSDTAETDVWLAPGGVIGRHMPKS
  330-  347 (21.11/ 8.90)	LSQA..TPEWKA...FVLKSLAD.
  357-  380 (38.53/23.15)	LTKWAKIGVWSDIEGLIEIFWPTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     196.14|      87|     370|     531|     622|       4
---------------------------------------------------------------------------
   69-  135 (54.19/27.10)	DNHDTDIAFTSDSGynsYDGsGTGEKGWE.PMV.WGLEEktkevlniheifealRPTPSEKPEDLFQLQ...................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  531-  572 (38.96/27.39)	.....................................................................tlsqidplispgtqldpidlsgahrdvymlqqlskqrgsnmsmsavgspvsasrhgssttgtphpattrpvskqemvgqklllammsllsyrlassfswlplnlctflpkfkkgpdaepeilsyspishgptiittvslglsddgslhvtpktisqsalqrlsntdlsdtaetdvwlapggvigrhmpkssidglsqatpewkafvlksladrgvdieqpgltkwakigvwsdieglieifwptslvfvrkyggsdidsypaisptgavdfklgtnvdelndlatqltwynagdslefaevwlsglasrdaekkrrlearnkaipvmdvdrkppfaaapttdrsgtvyptppgglsgndshptpggpttaptpgqtkvaeepipvvepptapptaEATVNGAD.MDLDDNWmkGDSTKVND.DI............FGGQGVGIgDDLFDI
  573-  646 (79.92/52.61)	DITEDDFGFFDEVG...GDG.GFADMGLEkPQVsTDLQP...............RPTTSHLSENMNDLN................................................................................................................................................................................................................................................................................................................................................................................................lgftnigsyvnDKLLDDMD.LDVDD..........................................
  889-  938 (23.07/ 6.33)	...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNHSDkLDGAPEW..ADMANVNDkDIdnlssaqrtlcdFISTDIAL.DGVFKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.89|      30|     100|    1156|    1190|       5
---------------------------------------------------------------------------
 1156- 1190 (42.10/44.91)	YENCRLGEILPVKTSQILDGLhgIAfqgQGKQQTI
 1259- 1288 (52.78/36.22)	FPNNIILQIVPIKNMAVYDGL..VV...QSHNQSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.77|      34|     252|     682|     731|       7
---------------------------------------------------------------------------
  660-  704 (45.74/21.05)	DP.TPTQAgseqsssQPNGQGHKSVRLETQsddtQHIIVQVETPPL
  716-  750 (56.03/37.11)	DPqSPRGA.......PPPSKGRLVLPFSRR....KSLYSPVDFASF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.18|      21|     200|      17|      37|      14
---------------------------------------------------------------------------
   17-   37 (38.86/22.75)	LSEVSYSVYRISSTFGSSPA.W
  183-  203 (25.43/12.09)	.SPVSASRHGSSTTGTPHPAtT
  218-  234 (27.89/14.05)	LAMMSLLSYRLASSF....S.W
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27916 with Med13 domain of Kingdom Fungi
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