Description | Uncharacterized protein |
Sequence | MADRLTQLQDAIDQLATIFYCALRYVGTHHDFIPTHNEPKVRDETLQPDPPHIFRSSQQELARDLVLKTKQIEVLIASLPGIGVSEDDQKERLKELGMELERAEEERLKSIREKEQLLVEFDEVVRSLKRV |
Length | 131 |
Position | Middle |
Organism | Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491) (Nematode-trapping fungus) (Didymozoophaga oligospora) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Orbiliomycetes> Orbiliales> Orbiliaceae> Orbilia> Arthrobotrys oligospora. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.563 |
Instability index | 53.95 |
Isoelectric point | 5.14 |
Molecular weight | 15233.18 |
Publications | PubMed=21909256 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi transcription coactivator activity GO:0003713 IEA:EnsemblFungi transcription corepressor activity GO:0003714 IEA:EnsemblFungi |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP27915 No repeats found |
MoRF Sequence | Start | Stop |
1) DQKERLKELGMELERAEEERLKSI 2) PGIGV 3) PPHIFRSS | 88 80 50 | 111 84 57 |
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