<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27914
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDAVLKKSLEAIESSLASLLESVTVDDPSSDAALALVAADDDLSSSLEQLVVHQTNHQKLLHLRALSSALDSELSTLLTTLSQARIELQSTTTTVFPAHARQVEYDALLSYATKISKFTRPPTHLKSQPQPADPTASTEASSSTALVLKSADVNGNNATKDGGVDGSSANNAAGAGAGETTGNAATRPTAEDIAMLDPTAGMPFVPWPTEEIMRRGILANMGSMETMPDAAAGQEAEPGAAEPDTTGEVAPPTGGSRQMSDADRERAREEAARREAERKQKEQEVFQGLDLYDPDSD |
Length | 297 |
Position | Middle |
Organism | Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491) (Nematode-trapping fungus) (Didymozoophaga oligospora) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Orbiliomycetes>
Orbiliales> Orbiliaceae> Orbilia> Arthrobotrys oligospora.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.461 |
Instability index | 47.88 |
Isoelectric point | 4.49 |
Molecular weight | 31245.02 |
Publications | PubMed=21909256
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP27914
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 57.15| 23| 24| 16| 38| 1
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2- 30 (25.67/13.30) DAVLkkSLEAiessLASLLESVTVDDPSS
31- 57 (31.47/17.59) DAAL..ALVAadddLSSSLEQLVVHQTNH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 40.32| 11| 24| 155| 165| 2
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155- 165 (20.38/12.29) GNNATKDGGVD
182- 192 (19.94/11.87) GNAATRPTAED
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 95.91| 25| 128| 121| 145| 3
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62- 84 (21.05/ 7.73) ...HLRALSSALDSELSTLLTTlSQA
96- 119 (32.43/15.27) FPAHARQVEYDALLSYATKISK.FT.
121- 145 (42.44/21.90) PPTHLKSQPQPADPTASTEASS.STA
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