<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27905

Description Uncharacterized protein
SequenceMSTVTKPRQQRGGRRPSQPHTGPNPSPLVIPGPQSQPQSQSHTSTPTSSAQSARAPHSRTSSKSANVIDLTSPTLPTPIRSRGRSGSISKSVAASPSVLRSAAQEAFPPTMPSKGQLVVTNSRKKARYSFPFPTTAQQQQNSQAPFLVSFNNSVPVELKMLPQPAHKKPKRSTRQKVAPQPTTQAASKDNKLKSYMIEPPLGCHSYPFRDNSGKELKDPKFPDFFPWKGTHPEDHVTESAARTGFSDKMHSGEQSSAKVLLAPLIKKNVGVDIISSIFVTILEKRQHIGRISTPSTFKFPPRVTFPGAKKESWLRDLANPDIPLRRLSRTIPLGLRGKELLDECTAKNIPLLRALWYVRCVGANELRSLKRKGAGSLAVGNETKWLREWTQGVVQYLEKGMADCGKDGQSKPSGKAEASSSSSASVARSTWKLRMTYILRLTSQLYSENLLDRGAFLEWYITLLETCSLDKLPLAMLILQIEWDHIVSSRKFSRRLVDALLGKVNQIISIRELDIYKPLLQRLAIHITRLLLNHRQAFINPKSWLINEAPLRACVDTSNPVIVSSINNIASRNRNLEPGNTKSSNGSTSPRKAAIDFLDRIRAPYDIEDVTTMFLALSKDYHQTVKVLCEWAVTSLRVGLHRLYFAVRLLRKVSRFGIQIQPPIHDFLLATGGGRRCKKHVYLLISELVRSKHFTAGKYMSWLISRGALMRHGSIDEEQPCYIRLLAEIPVNHQHTPSAQRNLRSNLLLQKGFLVNAEAASLAKAKEIVMDRIPGIFVIGNGKLPMVVKSESAFTFEEIKFLHGLTRNVMSELGFWVCAAVRKRQAQSTAPDNRGANSLGWRPSVSELPSTISPGEFLLVRKVLEELEDFGVLAEVIKLVSNSENPEILSAAADTLSSNVDVYFAIGIVGDILKALFDRYKALQVKRTMEHRPVEHYLTTSLFNFAQYQGCDGDIRQSLESDLLLGKTQAMLPHSLGDTLAEFGEGELDEGVEGLLSGTIPVQPAAVTKAFKVLVERVENGFRGTDMAVYKRFPRLLASLRQLDSATFDPLMENWMTDTIKNTSRPNLAVAFSNMLVAGCFELKSVIRITSEIVGQAGEDSGSIEAADVTELAFQTLALLLDDEDAKLDLTEQEMYSLRLERKRFRATNGKLFVGIFRKAIKLCVAAADPNLDSRLEYSMNNDIVLDLLRNLAFSDFDILVSELVEPLAPQSNPLISKHLSLLIDHLLDEHDSSDISEVDADVQVTRLLQHVNDFSVRLCQLKMRLIFEAEISHASDTAESANLRNAVTKAFVSSITEMDSDRGAIWADLVSVLDDTCVSQIRVYTEEMILNAPGFPNAAGSFIAVDEGSTDEEGIKRAGEMLARSLISAIDVTAGRNTGGGDMGTWLPPILADKMNVVLQALSGAGGEVTIQSDGVVTGGKETIGKVYKRLRSWVILFLRIVALHKAEFGSPKTSVVEQGRMVIGLCALLENRCVQNDDFMSEFALDVACAIIDDMNEESRQHIRRFLKRRYDLPQIGYMLGGIEALSMGPTGGVAGNVGATSEWLKGMSRGRLVEYSLKPWEQVSDPTPVAGDNDTSLSMTLFHARKLGCVCSG
Length1596
PositionKinase
OrganismArthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491) (Nematode-trapping fungus) (Didymozoophaga oligospora)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Orbiliomycetes> Orbiliales> Orbiliaceae> Orbilia> Arthrobotrys oligospora.
Aromaticity0.07
Grand average of hydropathy-0.198
Instability index45.43
Isoelectric point8.99
Molecular weight176276.27
Publications
PubMed=21909256

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27905
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     295.21|      68|     146|      16|      83|       1
---------------------------------------------------------------------------
   16-   83 (116.29/73.52)	PSQPHTGPNPSPLVIPGPQSQPQSQSHTS.......TPTSSAQSARAPHSRTSSKSANVIDLTSPTLPTPIRSRG
  105-  164 (91.82/56.26)	EAFPPTMPSKGQLVVTNSRKKARYSFPFP.......TTAQQQQNSQAPF.LVSFNNSVPVELK..MLPQP.....
  166-  229 (87.10/52.93)	....HKKPKRSTRQKVAPQPTTQAASKDNklksymiEPPLGCHS..YPFRDNSG.....KELKDPKFPDFFPWKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.91|      29|     146|    1037|    1066|       2
---------------------------------------------------------------------------
 1037- 1066 (45.35/33.05)	LASLRQLDSATFDPLMENwMTDTIKNTSRP
 1186- 1214 (48.57/29.33)	LDLLRNLAFSDFDILVSE.LVEPLAPQSNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.68|      17|     315|      85|     101|       3
---------------------------------------------------------------------------
   85-  101 (28.25/20.93)	SGSISKSVAASPSVLRS
  413-  429 (27.43/20.05)	SGKAEASSSSSASVARS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.89|      27|     315|     539|     573|       4
---------------------------------------------------------------------------
  543-  569 (47.44/34.87)	SWLINEAPL..RACVDTSNPVIVSSINNI
  701-  729 (43.45/14.85)	SWLISRGALmrHGSIDEEQPCYIRLLAEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.78|      17|     122|     340|     356|       5
---------------------------------------------------------------------------
  340-  356 (31.25/21.92)	LLDECTAKNIPL....LRALW
  463-  483 (25.53/16.36)	LLETCSLDKLPLamliLQIEW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27905 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELKMLPQPAHKKPKRSTRQKVAPQPTTQAASKDNKLKS
2) MSTVTKPRQQRGGRRPSQPHTGPNPSPLVIPGPQSQPQSQSHTSTPTSSAQSARAPHSRTSSKSANVIDLTSPTLPTPIRSRGRSGSISKSVAASPSVLRSAAQEAFPPTMPSKGQLVVTNSRKKARYSFPFPTTAQQQQNSQAPFLVS
157
1
194
149










Molecular Recognition Features






MoRF SequenceStartStop




1) AHKKPK
2) SRKKARYSFPFP
165
122
170
133