Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MQSVGTHQYNTSNSQQPHNHPTPQSPPGLYSASSGFNNSMNSQKVTSPRNNTHPVATNSLPTPRSPTLDATQSSSMEDVMDIDGSSASLKRRRSQGDLGDDDRPRKSRSRSRDPMEIDQGQPPISSLSTIRPRRTVPTMEELLAMPTTGPPSWLNLKKHVPLRPDLTSNLIEKYNLTSIAASVARTDSSGQKQKLRKSYKGKIAGLSGKNEVVTKAEQVAVPEGQEGWGQPVVQLVKGGLLEMLDIPDEEWRSLKVIGKEVPRNGNAGRPLDFNALRKGLSNWSKGPIPDYDASWLALEDPPLRPSANSTSGHPTGNSTLNNVKSNTPAATASPNGVNTSSPNPANMRSSGRKRRRDYGDGAWEGYGEDAEDDGGSGYDDDAAGKRKKKRKVSELQED |
Length | 398 |
Position | Head |
Organism | Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491) (Nematode-trapping fungus) (Didymozoophaga oligospora) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Orbiliomycetes> Orbiliales> Orbiliaceae> Orbilia> Arthrobotrys oligospora. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.996 |
Instability index | 58.82 |
Isoelectric point | 9.34 |
Molecular weight | 43153.18 |
Publications | PubMed=21909256 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27903 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 135.89| 31| 38| 63| 93| 1 --------------------------------------------------------------------------- 23- 50 (49.13/20.75) PQSPPGLYSASSGFNNSMN........SQKV.TSPRN 63- 93 (54.77/23.81) PRSPTLDATQSSSMEDVMDID.G....SSAS.LKRRR 104- 134 (31.98/11.44) PRK.....SRSRS.RDPMEIDqGqppiSSLStIRPRR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 112.19| 31| 38| 282| 312| 2 --------------------------------------------------------------------------- 282- 312 (60.52/27.82) NWSKGPIPDYDASWLALEDPPLRPSANSTSG 321- 351 (51.68/22.83) NNVKSNTPAATASPNGVNTSSPNPANMRSSG --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DYGDGAWEGYGEDAEDDGGSGYDDDAAGKRKKKRKVSELQED 2) KLRKSYK 3) YDASWLA | 357 194 291 | 398 200 297 |
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